7BMK,4OAV


Conserved Protein Domain Family
Ribonuc_2-5A

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pfam06479: Ribonuc_2-5A (This model is not part of the current CDD release)
Ribonuclease 2-5A
This domain is a endoribonuclease. Specifically it cleaves an intron from Hac1 mRNA in humans, which causes it to be much more efficiently translated.
Statistics
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PSSM-Id: 517296
Aligned: 142 rows
Threshold Bit Score: 101.79
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7BMK_A        295 QLQFFQDVSDRIEKESLDGP--IVKQLERGGRAVVKM--DWRENITVPLQTDLRKFR----T-YKG-GSVRDLLRAMRNK 364 human
XP_006142392  592 RYRTLRNVGNESDIKKLKPKskILELLNPGPSDCSRSfsQWTKEIDEYVMKKMNKFYeknrN-FYK-DTVGDLLKFIRNI 669
21_pfamImport   1 RFRTLRDVGNESDIKTRNTCskILQLLQPEASELSTSfnQWTEKVDEFVMEKMNEFYkk-gN-TYQ-NTVGDLLKFIRNL 77 
9_pfamImport    1 RYRTLRDVGNESDIKRQLEEskIVQLLQPEKSECSKSfaRWTSKMDKYVMDEMNNFYrnrkH-VYT-DSLSDLLKFIRNL 78 
XP_006942824  591 RYRTLRDVGNESDIKMRKCNsrIVQLLQLEMSECSRSfaQWTSKIDNYVMQEMNKYYenkrK-RYK-NTVSDLLKFIRNL 668
11_pfamImport   1 RYRTLRDVGNESDIKLRKTKsvILQILKPRTSEHSLSfaMWTSKIDQTVMTKMNEFYknrrNyYYR-DTVGDLLRFIRNL 79 
XP_006907824  592 RFRILRNVGNESDIKMRKQAsrILQILQPRTTE-QFSfdRWTTQIDSYIMKEMNNHYvksrN-FYQ-NTVGDLLKFIRNL 668
XP_003264481  592 RYRTLRNVGNESDIKTRKPEseILKLLQPGPSEHSKSfdKWTTKINECVMKEMNKFYkkngN-FYQ-NTVGDLLKFIRNL 669
4OAV_B        572 RYRTLRNVGNESDIKTRKSEseILRLLQPGPSEHSKSfdKWTTKINECVMKKMNKFYekrgN-FYQ-NTVGDLLKFIRNL 649 human
XP_003430926  579 RYRFLRDVGNESDIKTRNTEnmTLKKLNHNPSE-SYS--KWTSKIDKYVMTKMNKFYkn-eK-YQYqDKVTDLLKLIRNI 653 platypus
7BMK_A        365 KHHYRELP-AE--VRETLGSlPDDFVCYFTSRFPHLLAHTYRAM-ELcSHERLFQPYY 418 human
XP_006142392  670 GEHIDE-D-KNkdLKSKIGD-PSCY---FQKKFPDLVIYVYTKLqDT-EYKKHFPNTH 720
21_pfamImport  78 GEHINE-R-KNieMKSKIGE-PSQY---FQEKFPDLVMYVYKKLqNT-EYAKHFPKNL 128
9_pfamImport   79 GEHINEEK-NKe-MRLRIGE-P---FQYLQSTFPDLVMYVYKKLrNT-EYRKHFPKTH 129
XP_006942824  669 GEHINEEK-NRe-MKSRIGE-P---FQYLQEKFPDLVIYVYTKLqNT-EYKKHFPKTL 719
11_pfamImport  80 GEHINE-E-KNkdMKLKIGD-PSWY---FQKMFPDLVVYVYTKLqDT-EYNKHFPKTQ 130
XP_006907824  669 GEHVNE-E-KNkvMKSIIGD-PAQY---FQKKFPDLVIHVYVQLrDT-EYGRHFPKTH 719
XP_003264481  670 GEHIDEEK-HKk-MKLKIGD-PSRY---FQKTFPDLVIYVYTKLqNT-EYRKHFPQTH 720
4OAV_B        650 GENIDEEKhKK--MKLKIGD-PS---LYFQKTFPDLVIYVYTKLqNT-EYRKHFPQT- 699 human
XP_003430926  654 GEHIEEEA-NAg-MKALIGD----SAQYFQKTFPELVMHVYKNIqNT-EFMKHIPNAH 704 platypus
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