2H1T


Conserved Protein Domain Family
Glycolipid_bind

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pfam06475: Glycolipid_bind 
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Putative glycolipid-binding
This family has a novel fold known as a spiral beta-roll, consisting of a 15-stranded beta sheet wrapped around a single alpha helix. It forms dimers. It has some structural similarity to the E. coli lipoprotein localization factors LolA and LolB. Its structure suggests that it may have a role in glycolipid binding. Its genomic context supports a role in glycolipid metabolism.
Statistics
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PSSM-Id: 399469
Aligned: 52 rows
Threshold Bit Score: 158.568
Threshold Setting Gi: 503965477
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H1T_A                 9 TWAGLwrSpSSSWEALRLED----DQAESQLRAPDERSglpyqLDYRLRWDADWHLREAVFHVeSETGVRKLHLLADGRG 84  Pseudom...
WP_014210417          18 TWRAH--D-VPRMESVRVQLsgnrVKAHGRIVAAATPShpafsASYDLVTDEVGATKRLSMTVtLAERERQLSIARDEEN 94  Mycolic...
jgi:Mvan_5597         17 TWRAH--D-VSRMESARVQVsgdrIKAYGRIVAAATSAhpafsASYDLVTDEAGATKRLSLTVtLAERERQLSIARDEEN 93  Mycolic...
Q745R2                18 TWRAQ--D-VSRMESVRLQVsgnrIKANGRIVAAATDAnpafgAYYDLQTDETGATKRLGMTVtLAERERVFSFARDEEN 94  Mycobac...
O86358                18 TWRAQ--D-ISRMESVRVQLsgkrIRANGRIVAAATANnpafgAHYDLQTDETGATKRFGLTVtLAERERQLAIARDEEN 94  Mycobac...
MSJTU:JDM601_4035     14 TWRAP--D-APRMESVRVQLsgnrIKANGRIVAGATDAhpafsAYYDLATDESGATKRLGLTVtVAERDRQLVIARDEEN 90  Mycolic...
goetting:NONO_c02110  46 TWRAH--D-ASRMESVRVVLtgnrIRASGRIIAGDCGEhpafsASYDLVTDELGRTKRLSLRStVASGERHASIARDEEN 122 Nocardi...
jgi:Psed_0330          6 TWQAE--D-EVGLEGARVLIgptgFRALGRVVR--TGPhgeltASYRLTLNEDHSVERLSVTAaTAERERHLTMNRTEDG 80  Pseudon...
AMEG_HIPS:KALB_209    30 TWQAL--T-GPRLESARLVLsesrIKASGRVVAARSGDheaynASFELSVGEDGVVSRLLLRSaTAEDERQVSISRTEDG 106 Kutzner...
WP_012782797          25 TWQGC--S-VPRLEQVRVLVsehkLRASGRIVA--SGPaeqfnGSFELSVGEDGAVTRLLLRTaTVAEERHVSLSRSSDG 99  Actinos...
2H1T_A                85 HWQDGDg--E-ALPAFDGCLDIDIWPSPFTNTFPIRRLGLADGQRAE-IRALYIEAPALEPRSXRQAYTRLDA------S 154 Pseudom...
WP_014210417          95 MWLVQQhtgEsNRSAYGGALDVDVIFSPFFNALPIRRTGLYERSESVaIPVVYVRLPELSVGEATISYSSAPdg----iK 170 Mycolic...
jgi:Mvan_5597         94 MWLVQEhsgQtSRSAYDGALDVDVIFSPFFNALPIRRTGVYKDGGSVtVPVVYVRVPDLAVDVETISYAAVDgg----iR 169 Mycolic...
Q745R2                95 MWLVTDpqgE-HRAAYNGALDVDVEFSPFFNALPIRRLGLQERAASVtLPVVYVNVPEMSITADTVSYSSTGSrd--eiK 171 Mycobac...
O86358                95 MWLVTDhqgE-RRAAYNGALDIDLVFSPFFNALPIRRLGLHERAESIaLPVVYVNVPEMSVDAATVSYTSEGRld--giK 171 Mycobac...
MSJTU:JDM601_4035     91 MWLITDsrgQ-SRAAYDGALDIDVVFSPFFNTLPIRRARLHERAAAVaLPTVYLWLPEMSVVAAEASYRSTEag----iT 165 Mycolic...
goetting:NONO_c02110 123 YWLVDAgntH-VRSMFGGALDVDVVLSPFFNTLPIRRFGLAHITEDVqVPVVYVRVPDLLVAEAILTYSSGAdg----iH 197 Nocardi...
jgi:Psed_0330         81 FWLLDDgsgS-TRSDYDGAIDVDLERSPLFNTLPIRRLGLHTEHGDHvIPVLFVSLPTLSVELVDQHYRTVSVvdgdapA 159 Pseudon...
AMEG_HIPS:KALB_209   107 VWLVDRgrgA-ERSEFEGAVDVNVESSVLFNALPIRRLGLHRESGEHeLPVVWVSLPDLSVRLVRERYRTVSLsd--tgS 183 Kutzner...
WP_012782797         100 VWMVDRghgG-ERADFDGAVDVDVEFAVLFAAIPVRRLGLHREPGEAeLPVVRVSLPDLDVTVVRRGYRTASVgd--ggS 176 Actinos...
2H1T_A               155 HYLYENLEgsaFKAVLLVDEQGLVIDYPGLFQR 187 Pseudomonas aeruginosa
WP_014210417         171 LHSPVAE------TTVTVDSDGFILDYPTLAER 197 Mycolicibacterium rhodesiae
jgi:Mvan_5597        170 LHSPVAE------TVVTVDSDGFILDYPGLAER 196 Mycolicibacterium vanbaalenii PYR-1
Q745R2               172 VHSPISD------TTVSVDEQGFIVDYPGLAER 198 Mycobacterium avium subsp. paratuberculosis
O86358               172 LRSPVAD------TTVTVDSDGFIVDYPGLAER 198 Mycobacterium tuberculosis
MSJTU:JDM601_4035    166 VLTPGTDR---DGTTVTVDDDGFVIDYPGLAAR 195 Mycolicibacter sinensis
goetting:NONO_c02110 198 VLSPVSS------ATVTVDDDGFVLDYPGLAQR 224 Nocardia nova SH22a
jgi:Psed_0330        160 VVNFSSGE---FSADLTVDADGIVDHYPGLARR 189 Pseudonocardia dioxanivorans CB1190
AMEG_HIPS:KALB_209   184 VVSFARDE---SANDLTVDPDGLVIDYPGLASR 213 Kutzneria albida DSM 43870
WP_012782797         177 VVAIRAED---GEQDVTVDAEGLVVDYPDVAQR 206 Actinosynnema
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