Conserved Protein Domain Family
zf-FCS
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pfam06467: zf-FCS 
MYM-type Zinc finger with FCS sequence motif
MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.
Links
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Statistics
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PSSM-Id: 428958
Aligned: 39 rows
Threshold Bit Score: 34.2686
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q65174         56 HSSFKCWTCHLYFKTVPKfvptymRENErgeiemGVLGNFCSFSCAASY 104  African swine fever virus BA71V
Q9CU65        633 DIQLKCNYCKNSFCSKPEi-----LEWE------NKVHQFCSKTCSDDY 670  house mouse
Q14202        586 GIHLSCHYCHSLFSGKPEv-----LDWQ------DQVFQFCCRDCCEDF 623  human
CAG08242      525 AVQLKCNYCRGAFSLKPEt-----LEWE------DKVYQFCSKVCCEDY 562 
Q8QNI1         65 SYDKRCHNCAHFFEGVPvp---lpVSRDdlrhvyFCEGKFCSWQCAKSF 110  Ectocarpus siliculosus virus 1
Q98532         29 FVDKLCWHCCHKIPGITlq---ypFSYDdkrdvfKVGGQFCSWECIKGF 74   Paramecium bursaria Chlorella virus 1
NP_001171458  449 ADATRCSICQKTGEVLHE------VSNG------SVVHRLCSDSCFSKF 485 
A6QPH9        334 LNKSRCTICNKLTEIRHE------VSVN------NVTHKLCSNQCFNKY 370  cattle
Q9UBW7        420 LNKSRCTICGKLTEIRHE------VSFK------NMTHKLCSDHCFNRY 456  human
VFV43466      541 GPPRPCSFCRRSLSDPCYy-----NKVD------RTVYQFCSPSCWTKF 578
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