8D4Y


Conserved Protein Domain Family
CHDII_SANT-like
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pfam06461: CHDII_SANT-like (This model is not part of the current CDD release)
CHD subfamily II, SANT-like domain
CHD proteins (name derived from the presence of a Chromodomain, SWI2/SNF2 ATPase/Helicase and a motif with sequence similarity to a DNA)binding domain) are ATP-dependent chromatin remodelers found in plant and animals. In eukaryotes, there are three subfamilies, I, II and III. This domain is found in members of subfamily II which play a role in repression of genes involved in developmental regulation, including Mi-2 from Drosophila melanogaster, CHD3/4/5 from animals and PICKLE (a CHD3/4-related protein) from Arabidopsis. Sequence analysis revealed that this domain has a considerable similarity to SANT domains suggesting that it fold into this type of domain and it is integral to the DNA binding domain of CHD remodelers in subfamily II.
Links
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Statistics
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PSSM-Id: 517281
Aligned: 13 rows
Threshold Bit Score: 219.938
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8D4Y_A          2 SEAPRRP-SRKgLRnDKDKPL-PpLLARVGGNIEVLGFNARQRKAFLNAIMRYGMppqDAFTTQWLV-RDLRGKSEKEFK 78   human
5_pfamImport    2 NQMAKRP-YHR-TR-DTLEPI-P-LIEGEGRFLKVLGFNELQRKKFLTTLERYGV---GNYDWKEFV-DPLKPRTYDEIR 72  
Q9S775        920 VQTGRRP-YRRkGR-DNLEPT-P-LMEGEGRSFRVLGFNQSQRAIFVQTLMRYGA---GNFDWKEFV-PRLKQKTFEEIN 991  thale cress
XP_002515445  932 TQSGRKP-YRKrARvDNMEPI-P-LMEGEGRSFRVLGFNQNQRAAFVQILMRFGV---GEYDWKEFA-SRMKQKSYEEIR 1004
XP_014632791  932 ITTARRP-YKKkARtDSTEPL-P-LMEGEGKAFRVLGFNQNQRAAFVQILMRFGV---GDFDWKEFT-SRMKQKTYEEIK 1004
XP_002980063  919 dAAKRTPgSRKkPRvEATGPP-P-LMEGEGKSILILGFNRKQRAMFVQVLMRFGF---GDFSWSEFA-SCFKHKTVDEIK 992 
EFH45565      862 PRTVTKP-YRKrNR-DKS-EL-P-VMEGGGKSFEVLGFNRTEREIFLRTFKRYGA---GNFDWKEFI-HPLHMKTFDEIN 932 
NP_001190884  815 PRTVTRP-YRKrAR-DNSEEI-P-LMEGEGRYLMVLGFNETERDIFLRTFKRYGA---GNFDWKEFV-NPLYMKTYDEIN 886 
XP_009859352 1316 deefdnnenKRrGRrEKDRPLpP-MLARVAGNIEVLGFSGRQRRTYLNFVMRYGMpptENFQSRWLV-RELRVKSEKEFR 1393 vase tunicate
O97159       1380 eRKAKRR-LERrD----DRPLpP-LLARVGGNIEVLGFNARQRKSFLNAIMRYGMppqDAFNSQWLV-RDLRGKSERNFK 1452 fruit fly
XP_046455713 1402 pgrgrRR-KGTeRRdEKDRPLpP-LLARVGGNMEVLGFNARQRKAFLNAVMRYGMppqDAFNTQWLV-RDLRGKSERNFK 1478 common water ...
XP_056651915  583 GQSGRRQ-SRRqLKsDRDKPLpP-LLARVGGNIEVLGFNARQRKAFLNAIMRWGMp-pQDAFNSHWLvRDLRGKSEKEFR 659  gray short-ta...
XP_064408976 1314 rpegrRQ-SKRqLRnEKDKPLpP-LLARVGgniEVLGFNTRQRKAFLNAVMRWGMppqDAFTSQWLV-RDLRGKSEKEFK 1390 coelacanth

8D4Y_A         79 AYVSLFMRHLCEPGADGAETF--------ADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPEL 142  human
5_pfamImport   73 SYGLRFLKHIVEDKDVNSPTF--------SDGVPKEGLKCKDVLARIASVMLVQKKVKHMEANPTNPVFSDR 136 
Q9S775        992 EYGILFLKHIAEEIDENSPTF--------SDGVPKEGLRIEDVLVRIALLILVQEKVKFVEDHPGKPVFPSR 1055 thale cress
XP_002515445 1005 DYGILFLSHIVEEI-TDSPNF--------SDGVPKEGLRIQDVLVRIAVLLLILEKVKFASEKPGIPLFTDD 1067
XP_014632791 1005 DYGTLFLSHIAEDI-TDSATF--------TDGVPKEGLRIQDVLVRIAVLLLIRDKVKFVSQHPQTPLFSDD 1067
XP_002980063  993 EYAALFLMHVTEEQ-TDIPTF--------SDGIPKEGLRIQDVFVRLAILHLIWEKVKNLNENPSTSLFPSV 1055
EFH45565      933 KYGILFLQHIAENSKNNSSTFsvisamvsADGIPKEGIRSDELLMSMTFMMLLKEKCQFLDDHPTEPVFRDY 1004
NP_001190884  887 KYGILFLKHIAENPTDNSTNFkvitamvyADGVPKEGISSDELLVSMTFMMLVKEKCQFLDNHPTAPVFSNY 958 
XP_009859352 1394 AYTSLFMRHLCEPGSENSETY--------SDGVPREGVSRQHVLTRIGVMALIQKKVKEYKIINGDWSLPQl 1457 vase tunicate
O97159       1453 AYVSLFMRHLCEPGADNAETF--------ADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPEL 1516 fruit fly
XP_046455713 1479 AYVSLFMRHLCEPGADNAETF--------ADGVPREGLNRQHVLTRIGVMSLIRKKVHEFEHINGLYSMPev 1542 common water flea
XP_056651915  660 AYVSLFMRHLCEPGADGAETF--------ADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDL 723  gray short-tailed opo...
XP_064408976 1391 AYVSLFMRHLCEPGADGSETF--------ADGVPREGLSRQQVLTRIGVMSLVKKKVQEFEHINGKWSMPEL 1454 coelacanth
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