5J8V


Conserved Protein Domain Family
RR_TM4-6

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pfam06459: RR_TM4-6 
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Ryanodine Receptor TM 4-6
This region covers TM regions 4-6 of the ryanodine receptor 1 family.
Statistics
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PSSM-Id: 399455
View PSSM: pfam06459
Aligned: 45 rows
Threshold Bit Score: 219.169
Threshold Setting Gi: 827543781
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J8V_A        4382 MPDPTSDEVHGEQpAGPGGDadGAGEGEgegd--------aaegDGDEEVAGHeagpggaEGvvavaDGGpf---rPEGA 4450 rabbit
23_pfamImport    2 MPSPTQHGVEDGVlDEDASD--ASDPLK----------------SDRDDLIVDv------KG-----KELmkavvhTKRE 52  
EDW46995      3173 MRGPAPEQEEEPVv-------eEETFGRalp----------plpLEEPPGTVQafgldinKE-----ENGmykvvvHESP 3230 Drosophila s...
Q7PMK5        4460 MRGPAQEE-EEPIp-------eAEPSLRalp----------plpLEEPPGTVQafgldisKE-----ENGqyrmapHESP 4516 Anopheles ga...
Q17EB5        4472 MRGSTQEE-EEVIv-------eVEPSLRalp----------plpTEEPPSTVQafgldisKE-----ENGqyrvqpHESP 4528 yellow fever...
XP_016661950  4472 MSGTQSEET------TVEVVeeKSGSFRmlpa--------lpssGMDEPPSTLtdgnnmrKN-----SGS------PDSK 4526 pea aphid
XP_012544766  4486 MRGPQ---VEEPPp---EPTeeEKIGPRhlpa--------lppaDDTGQMQVSafglditKE-----DNGqiqvkpHESP 4546 domestic sil...
EEZ99829      4380 MRGPI-----EEP-AVLEIKeeEEKVGLsrvlp-------alpsSEEQNTQMQafglditKE-----DNGqykmaaHESP 4441 red flour be...
XP_023818818  4305 ilEPTLDEVMEGP-SGVNRLrkYSASFLcptelseigqmaaltsPREVDALSDifg-lklKK-----EGGqyrlvsKDLS 4377 Japanese medaka
XP_019222432  4305 iLEPTLDEVTEVP-SGVDQPrrYSASFSshrelreigqmgavtsprEVDVLSGifg-lklKK-----EEGryklvaQDLT 4377 Nile tilapia
5J8V_A        4451 GGLGDMGDTTPAEPPtpegspilkrklgvdGEEEELVPEPEPEPEPE-------------P-EKAdee-----ngEKEEV 4511 rabbit
23_pfamImport   53 AGFGDFSVEEAADTL---------------SMIASDYDSGFNTPRAT-------------RiKKRrkllrkgrrlDAQEA 104 
EDW46995      3231 ---------------------------------ANSSMEEGGESSPE-------------DgAAAsge-----lvE-GEP 3258 Drosophila s...
Q7PMK5        4517 ------------------------------ALSPSSSIEETGESSPE-------------Dgaa--------eltGEGVP 4545 Anopheles ga...
Q17EB5        4529 ------------------------------ALSPSSSVEETGESSPE-------------Dgag--------elsAEAAS 4557 yellow fever...
XP_016661950  4527 ------------------------------HLKSNSVGDDKDETSAE-------------NhEKEdgv-----dgS---- 4554 pea aphid
XP_012544766  4547 ------------------------------TTSTPSSGEEADASLDE-------------GlEHSe-------------- 4569 domestic sil...
EEZ99829      4442 ------------TTSqpssa-----egegeTTPEEDGEHPETETMEA-------------PlSLSdll-----ggEQAKR 4486 red flour be...
XP_023818818  4378 ASLTDLFQTASRTTV--------------------TTEIFEQHHSVFreqvdtdetakdgNmIQLkht-----enEKSEN 4432 Japanese medaka
XP_019222432  4378 ASLDDLFSTSSRTSAssdi---------ekhqITQIKDHTTTEEKNE-------------DkKMKteekks--------- 4426 Nile tilapia
5J8V_A        4512 PEA-------------------PPEPPKKAPPSPPAKKEEagGAGMEFWG-------ELEVQRVKFLNYLSRNFYTLRFL 4565 rabbit
23_pfamImport  105 STLsrtmsfdmttaddssctpwQSCMSACGRPARYKQQEIveDKNAAYLD-------CLNSFCMGTLGLFARNFYNFKIL 177 
EDW46995      3259 HQEpisivdllggeaakkaaqeRQEAQKAQEAAMASIEAEakKSSSAPQEtpavhqiDFSQYTHRAVSFLARNFYNLKYV 3338 Drosophila s...
Q7PMK5        4546 PGEqmtlvdllggeaakraaqeRTEAQKAQEATLASIEAEskKASTETKEpaavhqiDFSKYTKKCVSYLARNFYNLKYV 4625 Anopheles ga...
Q17EB5        4558 TEPpmtlvdllggeaakraaqeRSEAQKAQEATLANIEAEqkKASAETKEpaavtqiDFSKYTKKAVSFLARNFYNLKYV 4637 yellow fever...
XP_016661950  4555 -EQqasfvdllvgesarkdsiaGPEVLAQQQAVMAAVEAEikQKNS-VENpsafstiDINAYTHRALSFLARNFYNLKYV 4632 pea aphid
XP_012544766  4570 EQRppslidllggeqakkqaleRIEAQAAQQAAMSAIEAEskKAVQGPASssalsqvDLSQYTRRAVSFLARNFYNLKYV 4649 domestic sil...
EEZ99829      4487 AAQekvea----------qaaqQAVMQAIESESKQPVVTEpsAVSQ---I-------NFGAYSHRAVSFLARNFYNLKYV 4546 red flour be...
XP_023818818  4433 MKP----------------------ETNLTNKGCSNKSKDshGQHFALWE-------TISSQNKSLLSFFARNFYTMRFV 4483 Japanese medaka
XP_019222432  4427 ----------------ekkignEKAKARGRAKIFSNKLKEpqSQQSALWE-------TIGTHNKSLLNYFARNFYNLRLL 4483 Nile tilapia
5J8V_A        4566 ALFLAFAINFILLFYK-----------VSDsppgeddMEGSAAGdLAGagsgggs---------gwgsgagEEAEGDEDE 4625 rabbit
23_pfamImport  178 ALIITFIINFFLLFYK-----------VSG-------CDKSYWQ-SIN-----------------------EDLDVDESE 215 
EDW46995      3339 ALVLAFSINFMLLFYK-----------VTSfteeadsSAEEELIlGSGsgggaditgs----gfggsgdggSGDSEMEDE 3403 Drosophila s...
Q7PMK5        4626 ALVLAFCINFMLLFYK-----------VTTlgddedgEGGSGESlMGLgsglgsglgil-etgsgggeggsGDGEGEEED 4693 Anopheles ga...
Q17EB5        4638 ALVLAFGINFMLLFYK-----------VTTlgddeasEGSGDDMmELAsglgsglaeavleggsgdggsgdGGDEGDGED 4706 yellow fever...
XP_016661950  4633 ALVLAFCINFILLFYK-----------VTTladdlsdDGDVKEFaLGSagisnd-----------dmddsnSTEIADDEG 4690 pea aphid
XP_012544766  4650 ALVLAFCINFVLLFYK-----------VSTldgekaeGSGIGDIiAGSgsgqg--------------sgsgDGSG-EEDD 4703 domestic sil...
EEZ99829      4547 ALVLAFCINFMLLFYR-----------VSTlgddaegSGSKGIPdILEgsaeg--------------sgagSGESGEDDD 4601 red flour be...
XP_023818818  4484 ALFVTFAINFILLFYKvasmpaskgeeVRItsvdredLDsv---------------------------------iEEDSR 4530 Japanese medaka
XP_019222432  4484 ALFVTFAINFILLFYK-----------VTSfpnlkeeEGMTTSV-YGEd----------------------LNSDADNSE 4529 Nile tilapia
5J8V_A        4626 NmvyYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVI 4670 rabbit
23_pfamImport  216 R---LVLVDTTLYMEPALKIFRAIHFILSFSMLVSYYGLKVPLVI 257 
EDW46995      3404 IpelVHVDEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAI 3448 Drosophila sechellia
Q7PMK5        4694 PpekVHVDEDFFYMEHVLRIAAILHSLVSLCMLIAYYHLKVPLAI 4738 Anopheles gambiae str. PEST
Q17EB5        4707 PlekVEVDEDFFYMEHVMRVAALMHSLVSLCMLIAYYHLKVPLAI 4751 yellow fever mosquito
XP_016661950  4691 VlelVHVNEDFFYMAHVMRLAALLHSLASLAMLIAYYHLKVPLAI 4735 pea aphid
XP_012544766  4704 AlevVHIDEDFFYMEHVIKVAAVLHSIVSLAILIGYYHLKVPLAI 4748 domestic silkworm
EEZ99829      4602 PpelVHVDEDFYYMAHVMRLAAILHSVVSLAMLIAYYNLKVPLAI 4646 red flour beetle
XP_023818818  4531 GrdyFVLEESSGWMEPSLHLLAFAHTVISFCCIIGYYYLKVPLLI 4575 Japanese medaka
XP_019222432  4530 GrvyFVLEKNSGYMEPSLNFLAVAHTIISFCCIIGYYCLKVPLVI 4574 Nile tilapia
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