Conserved Protein Domain Family
RR_TM4-6

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pfam06459: RR_TM4-6 (This model is not part of the current CDD release)
Ryanodine Receptor TM 4-6
This region covers TM regions 4-6 of the ryanodine receptor 1 family.
Statistics
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PSSM-Id: 517279
Aligned: 37 rows
Threshold Bit Score: 219.946
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_040017262  4331 NMPDPTQFGIHGDA-IEREKVEAVESSGR--SDAAMa----PAGDV-EVDAMLEILSN--PKKEGG------KHVEPGLG 4394
23_pfamImport    1 TMPDPTQDEVRGEG-DEREKRLSERSSPK--EDLAD-----LAVNTsETELLSDIFGLd-LRREGGqykitpHNPNATLT 71  
17_pfamImport    1 GILEPTLDEVMGGP-------RGTRLSLTlqKELSGsrlaqTMASTrDMHVLSDIFGLt-VKKEGSgyrlisKDLTDSLT 72  
9_pfamImport     1 GILEPTLDEVMEGP-SGVNRLRKYSASFLcpTELSEigqmaALTSPrEVDALSDIFGLk-LKKEGGqyrlvsKDLSASLT 78  
22_pfamImport    1 GILEPTLDEVMEVS-SSVDQLRKYSASFSsqKELREigqmaSLTFPkEVDILSDIFGLk-LKKEGDqyrlvtQDLSDSLT 78  
11_pfamImport    1 EMPSPTQHGVEDGVlDEDASD--ASDPLK----------------SdRDDLIVDV------KGKELmkavvhTKREAGFG 56  
12_pfamImport    1 EMPSPTQHGVEDGVlDEDASD--ASDPLK----------------SdRDDLIVDV------KGKELmkavvhTKREAGFG 56  
4_pfamImport     1 LMRGPI-----EEP-AVLEIKEEEEKVGL--SRVLP-----ALPSSeEQNTQMQAFGLdiTKEDNGqykmaaHESP---- 63  
EDW46995      3172 LMRGPAPEQEEEPVv-------EEETFGRalPPLP----------LeEPPGTVQAFGLdiNKEENGmykvvvHESPa--- 3231
XP_018669433  4358 PTHERIQHSVENl--SDSGTDDTGQDQTK----------------GdKEDFISDVFGMdiKKSKELikavvhTKPEAGFG 4419 vase tunicate
XP_040017262  4395 DVSELSAETS-------PTDQKK-------KAAAQPAKAPENEA-EKA------------------------DTENQEKE 4435
23_pfamImport   72 ELLSSPVPPSapppapqPELRQRhqvnetfSALGLFIMYIHLEE-------------------------------HVVKQ 120 
17_pfamImport   73 DLFTPACRGAt-----aGQVPQKhqekpqtHIHQEEKTEEKGADgKQN------------------------Ksdqns-- 121 
9_pfamImport    79 DLFQTASRTTv--------------------TTEIFEQHHSVVCiLCL------------------------FVGQNEKS 114 
22_pfamImport   79 DLFSSTSRTM--------------------NDTDKTNKIISFGC--VF------------------------YVWNVFRW 112 
11_pfamImport   57 DFSVEEAADTlsm---------------iaSDYDSGFNTPRATRiKKRrkllr-------------------kgrrlDAQ 102 
12_pfamImport   57 DFSVEEAADTlsm---------------iaSDYDSGFNTPRATRiKKRrkllrkgrrlgqtssttssllsshYSEHPDAQ 121 
4_pfamImport    64 --------TTs-----qPSSAEGegettpeEDGEHPETETMEAPlSLS------------------------DLLGGEQA 106 
EDW46995      3232 ------------------------------NSSMEEGGESSPEDgAAA------------------------SGELVE-G 3256
XP_018669433  4420 DFTVDEAADTfsl---------------iaSDYESGINTPRTSKiKKRrkllrkgkqigqtasttstilsslENSSTSEQ 4484 vase tunicate
XP_040017262  4436 DKPKkeeeak----------epvveeKP----KTRSSQPKEASPAFMLTVFA-------FLKVYLTKLLNFLARNFYNLR 4494
23_pfamImport  121 EKQVkn-------------------eKMkskvRKHHNSKSDEPDLQESAVLK-------KILAYQRKLLNYFARNFYNMR 174 
17_pfamImport  122 ----------------------eailKDpkwrAQRLNPKSKEAENQPSALWE-------MVSTHNKSMLNYFARNFYNLR 172 
9_pfamImport   115 ENMKp----------------------EtnltNKGCSNKSKDSHGQHFALWE-------TISSQNKSLLSFFARNFYTMR 165 
22_pfamImport  113 KKTEkdrr---------------nakEEkkhgAKKCSNMSKEPQRQHSAVWE-------TISSHSKRLLNYFARNFYNMR 170 
11_pfamImport  103 EASTlsrtmsfdmttaddssctpwqsCMsacgRPARYKQQEIVEDKNAAYLD-------CLNSFCMGTLGLFARNFYNFK 175 
12_pfamImport  122 EASTlsrtmsfdmttaddssctpwqsCMsacgRPARYKQQEIETFKSTSH-----------------SQGLFARNFYNFK 184 
4_pfamImport   107 KRAAqekvea----------qaaqqaVMqaieSESKQPVVTEPSAVSQ---I-------NFGAYSHRAVSFLARNFYNLK 166 
EDW46995      3257 EPHQepisivdllggeaakkaaqerqEAqkaqEAAMASIEAEAKKSSSAPQEtpavhqiDFSQYTHRAVSFLARNFYNLK 3336
XP_018669433  4485 RLSNlksamsfders-gednispwytCMkecgRPARYKHEEKTEDRNAMYLD-------TWNAFCMGTMGLFARNFYKFK 4556 vase tunicate
XP_040017262  4495 FLALFVCFAINFILLFYKVTADPDEEIDEEk--------tW--------------------DgeEDDGLNTFFdmdeFVL 4546
23_pfamImport  175 MLALFVAFAINFILLFYKVTGNWVWEEHtht-------hpHrv----------------sdEtgEPLKPVSVR----FVL 227 
17_pfamImport  173 VLALFVAFAINFILLFYKVASSPAAQVEEKemps---aysAg-------------------D---DAEEGTVC----FVL 223 
9_pfamImport   166 FVALFVTFAINFILLFYKVRITSVDREDLD-------------------------------SviEEDSRGRDY----FVL 210 
22_pfamImport  171 LLALFVAFAINFILLFYKVRETLWEAISFS--------------------------------------DIAFY----FVL 208 
11_pfamImport  176 ILALIITFIINFFLLFYKVSG-------CDksyw--qsinEd------------------lD--VDESER-------LVL 219 
12_pfamImport  185 ILALIITFIINFFLLFYKVSG-------CDksyw--qsinEd------------------lD--VDESER-------LVL 228 
4_pfamImport   167 YVALVLAFCINFMLLFYRVSTLGDDAEGSGskgipdilegSaegsg----------agsgeS--GEDDDPPEL----VHV 230 
EDW46995      3337 YVALVLAFSINFMLLFYKVTSFTEEADSSAeeelilgsgsGggaditgsgfggsgdggsgdS--EMEDEIPEL----VHV 3410
XP_018669433  4557 ILALGLTFCINFILLFYKwhsi-----------------------------------nndlK--VDSESSEDEveesLIL 4599 vase tunicate
XP_040017262  4547 QESSGYMLPTLRFLAVFHTVISLVCLFGYYCLKVPLVV 4584
23_pfamImport  228 EESSGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVI 265 
17_pfamImport  224 EERSGYMEPSLRFLAVAHTIISFFCIFGYYCLKVPLVI 261 
9_pfamImport   211 EESSGWMEPSLHLLAFAHTVISFCCIIGYYYLKVPLLI 248 
22_pfamImport  209 EESSGYMELCLHFLSIAHTIISFCCIIGYYCLKVPLVI 246 
11_pfamImport  220 VDTTLYMEPALKIFRAIHFILSFSMLVSYYGLKVPLVI 257 
12_pfamImport  229 VDTTLYMEPALKIFRAIHFILSFSMLVSYYGLKVPLVI 266 
4_pfamImport   231 DEDFYYMAHVMRLAAILHSVVSLAMLIAYYNLKVPLAI 268 
EDW46995      3411 DEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAI 3448
XP_018669433  4600 EDTSKYMEPTLRAFSIIHFILSFSMLVSYYGLKVPLVI 4637 vase tunicate
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