1I8U


Conserved Protein Domain Family
CBM9_1

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pfam06452: CBM9_1 
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Carbohydrate family 9 binding domain-like
CBM9_1 is a C-terminal domain on bacterial xylanase proteins, and it is tandemly repeated in a number of family-members. The CBM9 module binds to amorphous and crystalline cellulose and a range of soluble di- and monosaccharides as well as to cello- and xylo- oligomers of different degrees of polymerization. Comparison of the glucose and cellobiose complexes during crystallisation reveals surprising differences in binding of these two substrates by CBM9-2. Cellobiose was found to bind in a distinct orientation from glucose, while still maintaining optimal stacking and electrostatic interactions with the reducing end sugar.
Statistics
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PSSM-Id: 399451
Aligned: 19 rows
Threshold Bit Score: 138.242
Threshold Setting Gi: 500203762
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1I8U_A         12 IDGEI-DEIWNTTE--EIETKAVAMGSL--D-KNATAKVRVLWDENYLYVLAIVKDPV-LNKDNSNP----WEQDSVEIF 80   Thermotoga ma...
Q11VS2         35 IDGNGnDACWSSAT--WYDVSYLWLGVQpsA-ADFTGKFKVTWNANKLFILAEITDDV-LNDNYANPlsnyWEDDTWEIF 110  Cytophaga hut...
Q07YE1         34 IDGVA-DAAWQQAK--WQTMPYLMDGALpdSaSDFSGKYKLLWDEHYLYLQAEITDDV-LLDTHADPavnyWDDDTLEIF 109  Shewanella fr...
Q15QE4         36 IDGHS-ENVWQQAQ--WHDMPYLMDGTFpeK-ADFSGRYRLLWDENYLYLQAEITDDL-LIDTHADPlvqyWDDDALEIF 110  Pseudoalterom...
WP_011874002  571 VDGRAgAEEYPGPA---LELSARWEGDEcaSrDDCSATAKLARHGDVLHVLVDVVDDVrGRALAARDckrhWRTDAVEIA 647  Saccharopolys...
Q11VQ4        913 VDGTV-DEVWNNVNvlPAAATKLLSGTVtnS-ADLSGNFKALWDDTYLYILADITDDVkISE-STNA----YDDDGVEVY 985  Cytophaga hut...
Q11NQ3        511 IDGVA-DGVWGGTNt-SASLNNVIDGTVanA-SDLSANYKAMWDATYFYVLVNVTDNVkTNNGGTDY----YNDDAVEVF 583  Cytophaga hut...
Q11VQ6        518 IDGTV-DAAWSNYT--AVPITNILSGTVssA-ADLSGNWKAMWDATNLYVLVQVTDDVkRNDAGTDV----YNDDGVEIY 589  Cytophaga hut...
Q11TF7        777 IDGTV-DGLWSNFP--STGITKNNTGTIssG-TDLSGNWKAMWDASNLYVLVQVTDDVkRNDGGTDV----YNDDGVEVY 848  Cytophaga hut...
Q47XV8         59 IDGLAdEASWQLAK--WQPIDKLILGMQpsA-EDFSGQFKIMWDEKQLYLLVEITDDI-LFDQHADPrhlyWDDDCLEIF 134  Colwellia psy...
1I8U_A         81 IDENNHK-TGYYEDDDAQFRVNYMNEQt----FGTGG-----------SPARFKTAVKLIE-GGY--IVEAAIKW----- 136  Thermotoga ma...
Q11VS2        111 LDENHSGgEHENNYNAFAYHVSTLGDI-----VDSDLgsp------rlFNAHATVSRTKSG-TTY--TWEAAFDVytday 176  Cytophaga hut...
Q07YE1        110 IDSDASGgDHQFNHSAFAYHIGLDNQA-----ADYGPdkq-----ahlYTSHLKSRWQRSSeAPYnvIWEVAIKLypndf 179  Shewanella fr...
Q15QE4        111 IDGDASGgNHRFNHSALAYHIGLDNQA-----ADIGDdek-----ahlYNEHVNSTWKRQLdAPNtiLWEVAIKRypnny 180  Pseudoalterom...
WP_011874002  648 IDPKGGS---ENTSSTFKLAVLPRTEAgppchFRDADnhqg---pgaeTAPGVRIASVERD-GGY--TVEAAIPL----- 713  Saccharopolys...
Q11VQ4        986 IDINNDK-ATTYSTNDFQYTFGWNKGTt----VSVLPag--------rSVAGITYTAVART-GGY--IIEARIPW----- 1044 Cytophaga hut...
Q11NQ3        584 FDIGNNK-TTTYGANDFQYTFRWNDNTi----YEKNN-----------KTTGVTFARVDNS-TGY--VMEMRFPW----- 639  Cytophaga hut...
Q11VQ6        590 FDFGNNK-PMAYGANDHQYTFRWNDATa----AYEINg---------hSVAGITKGSTNTT-GGY--IMEVRIPW----- 647  Cytophaga hut...
Q11TF7        849 IDLGNTK-ATTYGTNDQQYTFRWNDVTa----AYEINg---------hPVTGITKGISNTA-TGY--IVEVSIPW----- 906  Cytophaga hut...
Q47XV8        135 LDEDASGgNHQFNFNAFAYHIALDNQA-----VDIGEknaagsdnfvlLNDHITSVWRRNEsAPNkvIWEVAVRVyddsf 209  Colwellia psy...
1I8U_A        137 -------KTI--KPTPNTVIGFNIQVND-ANEKGQRVGIISWSDPTNNS------WRDPSKFGNLRLI 188  Thermotoga maritima
Q11VS2        177 iyangtsNPKa-TLTLGKQMGFAMAYCD-NDGGTTRQSFIGSEDVPGTNkn--vaYQNATVFGNLELV 240  Cytophaga hutchinsonii AT...
Q07YE1        180 k-edqqdKPL--LLTPNKVIGFMLAYCD-NDGSPVREHFMGSHEIPPVNgdknrgFIDASVFGRMTLK 243  Shewanella frigidimarina ...
Q15QE4        181 t-danpkAAI--PLKSGDVMGFMLAYCD-NDGSEVREHFMGSHDFAEQNgsknlgFITADVFGKITLK 244  Pseudoalteromonas atlanti...
WP_011874002  714 -------SALp-GSADPARMGLDLLVYDsDTDDLTGQTRIGWSAWGGVQ-------GDPYRWGRVVLE 766  Saccharopolyspora erythraea
Q11VQ4       1045 -------ATIqgTPAAGQLVGIDFMIND-DDDNGVRDGKLSWNAATDNA------WQDPSLFGTAILQ 1098 Cytophaga hutchinsonii AT...
Q11NQ3        640 -------STLtgSPAINQLVGFDVAVND-DDDGNARDRKISWAATADQA------WTNPSYMGTVILK 693  Cytophaga hutchinsonii AT...
Q11VQ6        648 -------VTIggVPAANSLHGFDVMIND-DDNGAARDKKIAWTATADDT------WNNPSLMGTIVLK 701  Cytophaga hutchinsonii AT...
Q11TF7        907 -------STIggTASLNSFQGFEVMIND-DDDGGAREGKLAWVASTDDT------WSNPALMGTVVLK 960  Cytophaga hutchinsonii AT...
Q47XV8        210 tmaiknpVAV--TLFEGKKLGFMLAYCD-NDGSKEREHFIGSIDIKAVNgsknlgYITADVFQKLTLI 274  Colwellia psychrerythraea...
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