1D5Y,5KAX,1EXI


Conserved Protein Domain Family
GyrI-like

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pfam06445: GyrI-like 
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GyrI-like small molecule binding domain
This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.
Statistics
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PSSM-Id: 399448
Aligned: 70 rows
Threshold Bit Score: 54.728
Threshold Setting Gi: 75009662
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1D5Y_D 125 EHKFVTLEDTPLIGVTQSYSCSLEq--ISDfRHEMRYQFWHDFLGNaptIPPVLYGLNETRPSqdKDDEQEVFYTTALAQ 202 Escherichia coli
Q8A8H8   6 EIMLLQQPEQPALAIEVQTYMKGMsqaIGEnFVRIDSLFKKQGE-----VTTDIPFVEYPDFE--SLTEDRIKMIIGLKS 78  Bacteroides thetaiota...
5KAX_B   8 VCELKELAPVPALLIRTQTTMSELgslFEAgYHDILQLLAGQG------KSPSGPPFARYF----GMSAGTFEVEFGFPV 77  Chlorobaculum tepidum...
Q8TS18 129 EPVIKEIPELRVLGKREKGTFVVT---IGKlINEICACVSSPENQRn--RVKTTGPIMFLCHD---EEYKETGADIEITL 200 Methanosarcina acetiv...
Q8TTD8   4 EVTIVELSPQPVLGIRKTGAYRE----IPVmLNRICEFAFSKNI------QITGYPVFLWHET---TVEEAQKAEVDENA 70  Methanosarcina acetiv...
P96690 122 QISKIKLPAMRVAYLQHEYVLGHD---IEHsLAELRTHLNVNED-----IFIGKIGLSISAAN--VKAKQFDKYSSIFMI 191 Bacillus subtilis sub...
Q24YP1 122 KIEERTLKERKIAVLKKELAISDD---LEQpIRELAKRNSLHAV-----MFLGKVGVSISSAN--LQRGNFDKFSAVFVV 191 Desulfitobacterium ha...
Q8YZW0 140 EVVIKKVAPIQVASIRQILPDNPS---IGQlYGEISEYLAQNGVK----AGDYYAGIWHDPGY--KDTDIDAEAVISIEG 210 Nostoc sp. PCC 7120
Q9RIX3 121 AVTLEELPARRVLAVTLDVPEGAG---LDWyDEAMCDVDSAAGER----SVLPPGGRYEHTLF---TEGHGRATVYVPFE 190 Streptomyces coelicolor
O26725  22 EISEKMVEGIRVAYIECRGSYER----IPEyISEVAGWVLKNGLQ----MTGRVYGTYYNTPE--EVDEEELLYEIGVSI 91  Methanothermobacter t...
1D5Y_D 203 DQAD----------GYVLTGHPVMLQGGEYVMFTYEGLG-TGVQEFILTVYGtCMPMLNLtRRKGQDIERYYPAEDakag 271 Escherichia coli
Q8A8H8  79 SKPL----------QGDEKIQSVILPARRIVVCLHRGNY-NELAQLYNEMTE-WIKTNGY-KASGTSIEYYYSNPd---- 141 Bacteroides thetaiota...
5KAX_B  78 EGGV----------EGSGRVVTGLTPSGKAASSLYIGPY-GEIEAVYDALMK-WVDDNGF-DLSGEAYEIYLDNPAe--- 141 Chlorobaculum tepidum...
Q8TS18 201 PVSGrv-------sVEDPKMEIKTLPAMKAISVIYRGPY-HEVEVAYNRIFS-FAEENSL-ETILPSRELYFNDPAe--- 267 Methanosarcina acetiv...
Q8TTD8  71 DIEVafpisefvenTGDEEIKVYELPGGKMAKVVHEGPY-EESILTYEKLFF-WITENGK-RIAGPVREVYLNDPQe--- 144 Methanosarcina acetiv...
P96690 192 LED-----------ENEKTSSEIIFPSREYLQIRFKGSH-PEAEPYYKKLLA-YMKEHHY-EVAGDSIEITLIDYGit-- 255 Bacillus subtilis sub...
Q24YP1 192 IEP-----------EDNCQENLSCLPGGNYLTLRFQGTH-PDAEASYIKMLQ-YMKENGY-ELAGDSLEFALIDYGlt-- 255 Desulfitobacterium ha...
Q8YZW0 211 SI------------KGNERIKIYELPGSETTACLIHHGSyETLAQAYATLVS-WIEANGY-NITAPNREVYIIGGNe--- 273 Nostoc sp. PCC 7120
Q9RIX3 191 APLPp---------EMPGRVRELHLPRRTAAVATHQGRH-DDLDLTYGAVGS-FAARNDL-RSQDLVEEVYLVGPRdt-- 256 Streptomyces coelicolor
O26725  92 AGEA----------EADERVKIKNLPSHRVIAALHEGPY-TEVGPVIHALIE-YAMENGY-EITGPVTEVYLNSPLe--- 155 Methanothermobacter t...
1D5Y_D 272 dRPINLRCELLIPI 285 Escherichia coli
Q8A8H8 142 vPEEEHVTRVEMPL 155 Bacteroides thetaiotaomicron
5KAX_B 142 tAPDQLRTRVSLML 155 Chlorobaculum tepidum TLS
Q8TS18 268 vPEEELMTEVQVQF 281 Methanosarcina acetivorans
Q8TTD8 145 vKPEEILTEIYAPL 158 Methanosarcina acetivorans
P96690 256 nNLDNYVTEILLPI 269 Bacillus subtilis subsp. subtilis str. 168
Q24YP1 256 nDPSKFITELQIPY 269 Desulfitobacterium hafniense Y51
Q8YZW0 274 qNNDSYVTELQFPV 287 Nostoc sp. PCC 7120
Q9RIX3 257 dRPELWRTLVAWLI 270 Streptomyces coelicolor
O26725 156 vDESELLTEVQIPV 169 Methanothermobacter thermautotrophicus str. Delta H
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