4QLA,1QO7,6IX2


Conserved Protein Domain Family
EHN

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pfam06441: EHN 
Epoxide hydrolase N-terminus
This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.
Statistics
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PSSM-Id: 399447
Aligned: 553 rows
Threshold Bit Score: 70.567
Threshold Setting Gi: 151361158
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4QLA_A        38 IKPFEITFSETMVKELKERIKKrR-------PFapple-gvgfKYGFNSKQLDSWLKYWAEe--yPFAERQKFLNQYPHF 107 domestic silkworm
EKG10339      20 LSSFKIDVSDGDLQSLKTLLKL-Lpip--rpNWengh---tdrRFGTPRDWLVEAVDYWQNt--yDWRKQEDVLNSIPQF 91  Macrophomina ph...
EEU48317      19 LRPFTVSVPQSRIDNLKTLLSV-Spvp--ppNFensr---sdgSYGVTRDWMGAALEYWKKt--yDWQQWEGVLNKIPQF 90  [Nectria] haema...
XP_011321873  19 LTASTISIPDSEIDRLKTLLKL-Spip--epNVwngr---edgSFGIPRSELLDLVNYWEKd--yDWRKWEATLNSIPQY 90  Fusarium gramin...
EMT69546      19 LTSSTISIPDGEIEKLKTLLKL-Spip--kaNIwnsh---edgAFGLPRDTLTELVEYWANd--yDWKKREATLNSIPQF 90  Fusarium oxyspo...
XP_002144616  30 SQSCKIDISSAEITELRSLAQR-Arlg--paTFentra-qpnkEFGLTRSWMDEAVKTWTSesafNWGKIQDNINSIPHF 105 Talaromyces mar...
EED23524      51 QQACKIDIPPTEITDLQNLVSK-Arlg--pvTFensqp-evtkEFGLTRSWMSKAIQAWSSestfNWNKIQDNINSIPQF 126 Talaromyces sti...
KDE08933      10 SERFYPLFEASELEGLRSTLAQ-CrtalpapTYastqaskdgkNYGVTSEWMSNTLQYWQEs--fDWSKRDKIINSIDHY 86  Microbotryum ly...
EEU38852      33 VQPTQLSIPRRVVKSFEKEISH-Qrdf--qiTWensq---tdrRFGVDHEWMSTALQHWRDk--fSWKDVEASTNRHPHF 104 [Nectria] haema...
EKC98417      14 VKEFKVAVPQAQIEDLRARLVN-Qapr--kaTWdntv---gpfHLGVKKNWLDETIERWKWf---DWRTVEDELNSFPQY 84  Trichosporon as...
4QLA_A       108 KTnI--Qg----LN---IHFMRITpkvpkgvE---IVPLLLLHGWPGSVREF 147 domestic silkworm
EKG10339      92 NVeVedDdg-qkYT---VHFAALFs------EnkdAVPIHFSHGWPGSFIEF 133 Macrophomina phaseolina MS6
EEU48317      91 QVeIedDdr-srYD---VHFMAIFs------AsprAIPVLFLHGWPGSVVEF 132 [Nectria] haematococca mpVI 77-13-4
XP_011321873  91 NItVtdDds-ksYM---INFFALFs------KnpsAIPILFLHGWPGSVVEY 132 Fusarium graminearum PH-1
EMT69546      91 DItVtdDds-tdYK---INFLALFs------KkpsAVPILFLHSWPGSVVEY 132 Fusarium oxysporum f. sp. cubense race 4
XP_002144616 106 TGqV--DhnghsYS---IHYMTLWs------QrsdAIPLVCIHGWPGCFLEY 146 Talaromyces marneffei ATCC 18224
EED23524     127 IStV--NhnnhsYS---IHYMALWs------LradATPLVCIHGWPGCFIEY 167 Talaromyces stipitatus ATCC 10500
KDE08933      87 MTtI--Kdd--eCGpfkVHYIAHIs------PdpnAIPLLLLHGWPGSAHEF 128 Microbotryum lychnidis-dioicae p1A1 Lamole
EEU38852     105 MTnI--TidtteLQ---IHFMAIFs------KktdAIPIAFFHGWPGSFLEF 145 [Nectria] haematococca mpVI 77-13-4
EKC98417      85 KAtI--NldgafYE---VHFLALFs------QkknATPILFAHGWPGSVLEF 125 Trichosporon asahii var. asahii CBS 8904
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