Conserved Protein Domain Family
GWT1

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pfam06423: GWT1 (This model is not part of the current CDD release)
GWT1
Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. PIGW and the yeast homologue GWT1 are involved in the addition of the acyl-chain to inositol in an early step of GPI biosynthesis. Mutations in PIGW are associated with West syndrome and hyperphosphatasia with mental retardation syndrome.
Statistics
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PSSM-Id: 517260
Aligned: 457 rows
Threshold Bit Score: 259.725
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
PPQ93066       7 YKQAKEDFVS-GTTGSSITHVNFISLVAL--TSVAlYA------AIqtrt--rkpRtRsgagAGSGFFASWALLILPMLL 75 
KAF7491916     6 IKIHKENFVKgNQGSSSPLETFELIVMMQ--LSHI-FFels-llNLs--------R-Irl-nKLFRTVIDFIANYLPFIL 71 
CAF1207127     4 YRQRKEFFVS-NLNGTTLYETGAMMINIC--TTYF-LYqil-qsSFpk-------------sRTWNYFSEYIIIVIPLIF 65 
CAF1327602     4 YRQRKELFIS-NLNGTTLYETASVLINMC--TTYF-LCqil-khSFv--------NnL-----FFNFLFENCIIIIPLIS 65 
CAF3321670     4 YRHRKELFVS-NLNGTTLSETGSILLNGC--ATYF-LCql-------------vkVnIak-sSFLNLLLENSIIVIPPLF 65 
CAF3767379     4 YRQRKEFFIS-NLNGTNLYETGSILINGC--ATYF-LCqil-ksTIls------lSnIky-iSIYNFFFENFLIIIPLIL 71 
GAV08612       3 RKQEHELFVQ-NLTGCSSLTVFSVLACIA--LFVF-LDell-rlSWk--------KnLvs-kKWTNFLLDFFVLVLPVLS 68 
XP_034099564  65 DKKSWQSVRS------SLS---SFLMIMPtlLGFTlSq------LLcqrlhl---------hstrrFLMEFIVVSLPTVC 120
XP_004531481  49 DIYPKDKWGT------SLNVIRIIWTVLPvvPVMViTh------IItstigpaiqLnYv-----fTYLLEIVFIVLPIVF 111
XP_017303071  13 YRFLHEKFIS-NNNGTTFAESVTI--LMS--PTLLiVpsqlivyTLlnp---snpRkSpafnyFLIYLVEFVCIALPMIT 84 
PPQ93066      76 AMTLAADYpyvLW-LSvllggcaawvlrmpvvergtplpstqsqsrsqpgsparlgagagvavgtaaggggvsggggggg 154
KAF7491916    72 ATTFLSDY---VGiLIslmsiaiiinaiivylnrttai------------------------------------------ 106
CAF1207127    66 TTTALSSF---NHlLHfilcgislliylirnpss---------------------------------------------- 96 
CAF1327602    66 ICTLSSSI---SHiFHfviwsialfiyflkkps----------------------------------------------- 95 
CAF3321670    66 VCTLLSSF---NYlFLivlwslcfliyftqkas----------------------------------------------- 95 
CAF3767379    72 ICTLLSSL---SYiFHfifwfigfliyftkknl----------------------------------------------- 101
GAV08612      69 TVTILSGW---LTsLLiflaitslfasavrialssgmtr----------------------------------------- 104
XP_034099564 121 NMMLSSECnalYVtLVgayiayllwrsgvwsrfp---------------------------------------------- 154
XP_004531481 112 LVSLYNNLlgyLLpALllgawvyyweliqrp------------------------------------------------- 142
XP_017303071  85 FTTIFSNY---FAfYFilmtlllfimlsftsvi----------------------------------------------- 114
PPQ93066     155 ggggvpmrereggemwththtkmktkgvrlpplpalSTYRAHMMLMTVLAILAVDFPVFPRALAKCETFGVSLMDLGVGS 234
KAF7491916   107 ---------------sfndlrlseidrfgsdripyvSNLLSTLLIATTFSILAVDFSIFPRRFSKTEIKGWSLMDFGVGG 171
CAF1207127    97 -------------------sserqssnpnssysrilEVFRGQMLVVTCICILAVDFPIFPRRYAKTEHYGYSTMDLGVGL 157
CAF1327602    96 --------------------sinnsqtinksysrliELTRGQILIVTCICILAVDFSIFPRRYAKTENYGYSIMDLGVGA 155
CAF3321670    96 --------------------aikliqtnnksysstiELFRGQILIATCLCILAVDFPIFPRRYAKTENYGYSLMDKGVGL 155
CAF3767379   102 --------------------siksieinkqsyshiiELFRGQILIATCICILAVDFSIYPRRYAKTENYGYSIMDLGVGL 161
GAV08612     105 -------------qkddlqvgeqaqagrqslefmvvSQFRGCVLLLACVTILAVDFPVFPRQMGKTERQGYSVMDLGVGA 171
XP_034099564 155 -------------------aettdysfklgkrpivfTLIRATAYLGTGAAILAIDFKHFLVGNGKSRDFGATIMDMGIGL 215
XP_004531481 143 ---------------------rnwyfnwggrrphvlTLNRATINLLTAYCILAVDFPSFPKYFVKNHQFGASLMDIGIGL 201
XP_017303071 115 -------------------dddnierviaipkrptiTYFRCIVNMGSAIAILGVDFKIFPRRFAKTETFGFGVMDAGVGL 175
PPQ93066     235 FVFSQGVV--SAIplvkdpRylRApLLPKLFRVVR-KSLPVIALGGVRVLFVKGTEYPEHVTEYGVHWNFFITLAVLPIL 311
KAF7491916   172 FIAINGGLapESRk-----N--RNsFQENFFKTFR-SSFLFFSLGMIRLLSVKLLNYQEIISEYGIHWNFFFTLCFVKLI 243
CAF1207127   158 FAMAHGMVssEAR------D--KQt---KIRDLFL-ENFVLLLLGIIRLLSIKYFSYVEHVSEYGVHWNFFLTLCFMKLF 225
CAF1327602   156 FTITHGMVssEAR------N--KQt---NFKELLV-ENFVLFILGLIRLISVKYFSYIEHISEYGIHWNFFLTLCFMKLI 223
CAF3321670   156 FALAHGIVsaEAR------N--KQt---SLKDLFL-ENFILFLLGLIRLISIKYFSYVEHVSEYGIHWNFFLTLCFMKLI 223
CAF3767379   162 FAISHGLVslEVR------N--KQi---NIKELFF-ENLILCLLGLIRLILIKYFSYIEHISEYGIHWNFFLTLCFMKLI 229
GAV08612     172 FVIANALAapQTKe----mE--RSsWK-MVVKEVQ-DTLVLLILGFSRFVSVLLTDYPVPEAEYGKHWNFFCTLAFVKIL 243
XP_034099564 216 FVVIMGLV--SQRs----------rHLGDIKR-LPkVVLPLLVLGSARTLVITMIDYHQDEREYGKHLNAFFTLGFTKLF 282
XP_004531481 202 FVYSMGVV--SKPp----------qSISHFVK-LFvNVFVLVVLGGIRTSIMRNTKFSQNEREYGIHWNAFYTLALTKFG 268
XP_017303071 176 YIVSNALTt--pVnim-dtN--Si-NMNNFYKSIK-HTVPLIVLGTARVIVLESLNYQQHITEYGVHLNFFFILSIIKFI 248
PPQ93066     312 QVL--LhplLvyL-QIsiS-----MLGALVAIVQQLALSrfgfgWQ--DYVLFa--Pr------aS---LVSMNKEGLVS 370
KAF7491916   244 STI--Lc-sL--M-KGi-Nl---cLISIIVAIVHQFLLKf---cLK--EFILDs--Dr------sG---FLAANKEGLIS 297
CAF1207127   226 ASC--Ll-fI--Tkn-------vlLSIAVSLVFHQMFLLq---yLQfdTYLINs--Nqt----riG---FTDANREGIFS 281
CAF1327602   224 GNC--Ll-lI--Tkn-------lfALICLTLLFHEIILLr---yLQfdNYLIEv--Nnl----riG---FIDANREGIFS 279
CAF3321670   224 GYY--Lf-kL--Ikn-------ihLLIILILSFHEFILLk---yFHydDYLISs--Nnl----rtN---FIDANREGIFS 279
CAF3767379   230 GYY--Ll-kI--Ikn-------lyLLIFLILLFHEFILLk---yFQfdNYLIQs-sNni----rkN---FIDANREGIFS 286
GAV08612     244 GRLaaV---L--V-PPga----vaALGVCLAIVYECCLRl---gLY--SFVLDa-aDkavpasssSivqFLIDNRSGLSS 307
XP_034099564 283 GSI--Vs--L--L-AP--SdkqllPLSLGVLGLHELILQl---sLS--EYVMQs-vEr------iG---LLDSNREGLSA 338
XP_004531481 269 ATI--Ls--L--L-CK--HgfmlfAGGVVFAVIHEVNLQh---nTS--NFVMNanvVr------nT---LFKANREGICS 325
XP_017303071 249 VPL--Tl-pF--MkPSsl-----yFYTIALTVMQQMILMy---rAQ--DWVLSn-aLr------nN---FLDANREGIVS 303
PPQ93066     371 LLGYLSIQLLGLSAGTIVLPptpsffsrRqkalakaldgaagvgvggggrkrrnsdpvdsdeeeeytgktrakpsklrqa 450
KAF7491916   298 LIGFIPVYLTFIQIGRFYFP--------S--------------------------------------------------- 318
CAF1207127   282 LSGYVCLHLIGVYMGKYVIRn------eR--------------------------------------------------- 304
CAF1327602   280 LGGYVCLYLIGIFFGRLIINy------eR--------------------------------------------------- 302
CAF3321670   280 LGGYVCLYLIGISCGRFIIKy------eY--------------------------------------------------- 302
CAF3767379   287 LSGYICLYLIGILIGKFIIYn------eY--------------------------------------------------- 309
GAV08612     308 CLGFLAMFLMWLYVGRLFRN--------Q--------------------------------------------------- 328
XP_034099564 339 LPGCIALYLLSIYVAKWYMSq-------Dhl------------------------------------------------- 362
XP_004531481 326 ILGFISIYLFSMLMGHHLRIq-------Ndvi------------------------------------------------ 350
XP_017303071 304 ILGYLSLYLGGVAIGLQFPNkrg--------------------------------------------------------- 326
PPQ93066     451 drdgdvgggqldldldldlaapRQldk------tatELC--AYSIVW---WALLgMVRLagvdggwkqgeGGVSRRMVNL 519
KAF7491916   319 ----------------------RKnit------eisSLTlkLSIIAFsslILMY-ISHYl---------iDPISRRQVNL 360
CAF1207127   305 ----------------------EQrfkdiiskftiaSLIl-CAISY-------------------------NSSRKLCNF 336
CAF1327602   303 ----------------------NQqflqmtikfsiaMIIl-CGISY-------------------------NTSRKLCNF 334
CAF3321670   303 ----------------------EQkfkqmairffilMIIl-CAISY-------------------------NPSRKLCNL 334
CAF3767379   310 ----------------------KKkfiymgiiffifMFIl-CTISY-------------------------NPSRKLCNL 341
GAV08612     329 ----------------------RQstaai--lrlfqDLAl-YSLVLYg--ATLM-L--------------PLPSRRVVNM 366
XP_034099564 363 --------------------nyVQfcs------klrHMFi-FCIIGW---LLVF--VCAf---------tCGIARVTFNT 401
XP_004531481 351 --------------------trKAyfk------klkVTMv-SAILLW---VSVF--SCIfl--------sISIARVTCNL 390
XP_017303071 327 -------------------akvRDnme------fvlKLGa-ASVVLG---LLTG-YTYSaf----------gISRRLTNS 366
PPQ93066     520 SYILWV-------A---AFNVS------FLLCYVvVL-DL-----Wi---------yAdagdasdsdpATSastkarmqs 568
KAF7491916   361 AFIFWI-------IftcSFNIIi-----ELVYFV-FI-QI-----Vq----------Pri------dyESK--------- 396
CAF1207127   337 GYITST-------A---GLACMtlagfgVTQWLL-V----------------------------------Rkgys----- 366
CAF1327602   335 GYISST-------T---GLACLiiasysVILWLL-I----------------------------------Rkgys----- 364
CAF3321670   335 SYISST-------T---GLACMcfacysVIQWLL-L----------------------------------Rksys----- 364
CAF3767379   342 SYITST-------T---GLACMclgcfsIIQWLL-L----------------------------------Rkgyl----- 371
GAV08612     367 SYMFWVsyqamafL---AFT--------LLTRLL-LV-SIdqssaVllqsfdprnvkSslwniyqafqEGKfevdltsh- 432
XP_034099564 402 GYVIWL-------I---SICLS------LMLLYA-FLfEFa----Lviarqnt---------llipdtIKRpaqmaqs-- 449
XP_004531481 391 GYILLV-------L---AIAQT------MTGYYM-LGfHSi----Ls---------qPdesysad--------------- 425
XP_017303071 367 CYILFI-------L---LVSVL------ILILCL-LS-EA-----Llin------------------ftkKasn------ 399
PPQ93066     569 krtsammkmddndndnpprLLEVINEYGLYVFLLANVLTGLINLSMSTMYMSDGKAMLVLSVYSMVCCGVPW-II 642
KAF7491916   397 -------------------ILKIWSRKGLIIFLIANLLTGAINFFFNTLQIANNLAFIILISYISCLTLIGF-LL 451
CAF1207127   367 ---------------tesaLLKSVNQKGLDVFLLGNVLTGMINLNINTIDTPDFLALFILILYTIIITSSAY-FL 425
CAF1327602   365 ---------------testLLKYVNQKGFDMFLLANVLTGIINLNLNTIDTSNSVALCIIIIYMFILSTYVYcFp 424
CAF3321670   365 ---------------iesmLIKNFNLKGLDIFLLANVLTGIVNLNINTIDSSDFTSFMIILLYMFTVSSFTY-FC 423
CAF3767379   372 ---------------iesiLIKNINQKGLDIFLLANILTGIINLNINTIDTSNFLSLFIILIYMFIITIFTY-FC 430
GAV08612     433 -----------raslftptILSAMNYNSMAIFLLANVLTGLINLSIDTTKCGDLVSMLILTAYLTVITSAAY-FL 495
XP_034099564 450 ------------kptdlpaFVESLNMNGLTHFMISNFLTGFVNMSLEPMQRSSLQGIFILISYMLVTGGVVY-VL 511
XP_004531481 426 -------------qeylpsVVEAVNKNGLVYFVVANLLTGGINLCLEETDYVLEASIIILSAYMFLTTIPVQ-IL 486
XP_017303071 400 ----------------vpeIFKAINQYPLLFFILANLLTGIVNLSVNAIYIGPVTSFLILICYMFTLCSITI-GF 457
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