Conserved Protein Domain Family
GWT1

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pfam06423: GWT1 
GWT1
Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. GWT1 is involved in GPI anchor biosynthesis; it is required for inositol acylation in yeast.
Statistics
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PSSM-Id: 399434
View PSSM: pfam06423
Aligned: 188 rows
Threshold Bit Score: 73.4091
Threshold Setting Gi: 307208003
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009156874             345 MNREGVFSFVGYLAIFLCGRGT-G---MRVVrfrgEeaaaaladadgaagagaagp------------------------ 396 Exo...
Q4N0H9                   135 ANREGLLSIPNSISASLFVLLV-TkasIYYYkrg---------------------------------------------- 167 The...
CAG25391                 587 SNKEGLFNIIGSVNLYLFSFSL-F---KYLTkqrtYittsnipknkkdmnnsmyskngnhtnsninnrnhkivirnnhin 662 Pla...
EDL46441                 453 QNREGLMNVIGSVNLYLFSFSLwN---GYVFpdegQqwer---------------------------------------- 489 mal...
XP_002261519             488 lNREGLMNVIGSINLYLFSFSLwN---GYVM----Qde------------------------------------------ 518 Pla...
WGS:AAFB:cds.EHI_031230A 282 ANREGFLSIIGYTSIQIASTAM-G---YYYTlgctk-------------------------------------------- 313 Ent...
PDM60493                 296 ANREGICSLAGYIAIYYYSRAM-G---RFIAktalagl------------------------------------------ 329 Pri...
EGT41362                 297 ANAEGLTSLLGYLTIFYASLAI-G---DFMAktsir-------------------------------------------- 328 Cae...
XP_001950684             183 ANREGILSLIGYEAIFLYSLTM-KsrlSVFInknhl-------------------------------------------- 217 pea...
EGF82798                 216 MNREGICSMAGYYCIFLISAEI-G---ARIL------------------------------------------------- 242 Bat...
XP_009156874             397 --------sggggggggggghdgknakHeqvtdqvq-----------------------ltrlerrVVLKDLLVQSVIYS 445 Exo...
Q4N0H9                   168 ---------------------------------------------------------------kifKTLISYFFSCFLFF 184 The...
CAG25391                 663 kyeqdntnkyinkqinnnknkldeeekLkklkklknkkknlkkkikyyllylqyiiniykeeyytiYYNIKLIISSFIFY 742 Pla...
EDL46441                 490 ------------------------gkaArrpdeaartp------------------geghgqrspvRLTLKLLALSLLFH 527 mal...
XP_002261519             519 --------------------------iQqgkgeqse----------------------gyiqlspvCFTLKLFTMSLMFY 550 Pla...
WGS:AAFB:cds.EHI_031230A 314 --------------------------------------------------------------qyrfKLDVIIVIIAFIGY 331 Ent...
PDM60493                 330 ------------------------------------------------------------rvrswsAAVLHMLLLCGIFA 349 Pri...
EGT41362                 329 -------------------------------------------------------------vkswiRRCFQLLIISFFLF 347 Cae...
XP_001950684             218 --------------------------------------------------------------innmFLLIVTASLSIALF 235 pea...
EGF82798                 243 ---------------------------Pkvqpfn--------------------------mgmirfKVLTATVGMSFLLY 269 Bat...
XP_009156874             446 AL---------YylstdflffnlnVSRRLANLPYVLWVAAFNNAQIFGFG-LIEAcgvEFGygggggggpttglhrggra 515 Exo...
Q4N0H9                   185 TVanvlyfaklK------------SSRSLGNFRYLMYVMFLYTFGLGSVV-SFEI------------------------- 226 The...
CAG25391                 743 LLhiilnlyknY------------SVRILCNANYIFLITSLGLFSCALSFsLEDI------------------------- 785 Pla...
EDL46441                 528 LLhlllnyyrnY------------SVRILCNANYICVVSSVSLFAAALSY-LVEK------------------------- 569 mal...
XP_002261519             551 LIhlllnyygnY------------SVRILCNANYICVISSVSLFAVALSY-LVEA------------------------- 592 Pla...
WGS:AAFB:cds.EHI_031230A 332 IAyevislyipP-------------CRPLINLTY---FIALMSQMMICYA-ICDVipmYL-------------------- 374 Ent...
PDM60493                 350 AAqlaaeaalgPp------------SRRLVNLPYILAMISMECYLLAGCI-GVQTisyIIWaa----------------- 399 Pri...
EGT41362                 348 LIqlatekfvdP------------PCRRVVNITYIFSQLTLMTFATAVCL-SIQMfnvVVWc------------------ 396 Cae...
XP_001950684             236 LLtfaisfvfgV-------------SRRLANAGYVYWVLSISSYLLFMSImIENFinvLL-------------------- 282 pea...
EGF82798                 270 LVctlhl--------------dlqvSRRLANASYVFWVTAVCTSLLAGLF-VVDH-----T------------------- 310 Bat...
XP_009156874             516 agqdvvrGGkeeetEEGEGDDVQDQTTSRILRAFNNNGLLVFLVANLLTGLVN 568 Exophiala dermatitidis NIH/UT8656
Q4N0H9                   227 --------------------VYPRYKENDLINTIGRYPLVVYLVANLITGFVN 259 Theileria parva
CAG25391                 786 ---------------LLRYKKYKINIDITVLDKINKNTLIVFLFSNILVGMFN 823 Plasmodium falciparum 3D7
EDL46441                 570 ------------------VLLREKTTTIPVLQQMNRHSLAVFLFCNVTMGTFN 604 malaria parasite P. vivax
XP_002261519             593 ------------------ILLREKTTAIPVLQKMNRHTLGVFLFCNITMGTFN 627 Plasmodium knowlesi strain H
WGS:AAFB:cds.EHI_031230A 375 -----------------------PVKQTAGSNGLSLNQLPLFLIANVITGVVN 404 Entamoeba histolytica HM-1:IMSS
PDM60493                 400 ------rVPh-----FGSEENPFATSEPCLMTALNKHPLLFFLVSNVTTGVVN 441 Pristionchus pacificus
EGT41362                 397 ------aSFp----QFSRGDDPFSPVSPCLSDSINRHSLLFFLISNVLTGLIN 439 Caenorhabditis brenneri
XP_001950684             283 ---------------HKIGRLGEFNRISLIIDSINDNLLFFFLFANVVTGVIN 320 pea aphid
EGF82798                 311 --------Ls----RIFKNSAEQLKDSPVLFQSLNRYQLVAFIVANILTGLLN 351 Batrachochytrium dendrobatidis...
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