Conserved Protein Domain Family
Lamprin

?
pfam06403: Lamprin 
Lamprin
This family consists of several lamprin proteins from the Sea lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix of lamprey annular cartilage. Although not generally homologous to any other protein, soluble lamprins contain a tandemly repeated peptide sequence (GGLGY) which is present in both silkmoth chorion proteins and spider dragline silk. Strong homologies to this repeat sequence are also present in several mammalian and avian elastins. It is thought that these proteins share a structural motif which promotes self-aggregation and fibril formation in proteins through interdigitation of hydrophobic side chains in beta-sheet/beta-turn structures, a motif that has been preserved in recognisable form over several hundred million years of evolution.
Statistics
?
PSSM-Id: 399418
View PSSM: pfam06403
Aligned: 3 rows
Threshold Bit Score: 33.0237
Threshold Setting Gi: 462476
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P33575     1 MAAAIQALLVLALLHLATATPVIGKQTVSTLSTGYLGHPVv----GGLGYGGLGYGGLGVAGLGVAGLGYGGLGYPGAAL 76  sea lamprey
P33577     1 MAATMQALLVIALLHLATATPVVTKHKVSTFSTGFLGHPV-----GGLGYGGLGYGGLGYGGLGVAGLGYGGLGYPGAAL 75  sea lamprey
AAC97498   1 maaaiqallvlallhlataTPVIGKQTVSTLSTGYLGHPVgglgyGGLGYGGLGVAGLGVAGLGYGG-----LGYPGAAL 75  sea lamprey
P33575    77 GGVYTHHAAglvhpYGGLGY 96  sea lamprey
P33577    76 GGAYTHHAA-----LGGLGY 90  sea lamprey
AAC97498  76 GGVYTHHAA-----LGGLGY 90  sea lamprey
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap