8JUT


Conserved Protein Domain Family
Alpha-2-MRAP_C

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pfam06401: Alpha-2-MRAP_C (This model is not part of the current CDD release)
Alpha-2-macroglobulin RAP, C-terminal domain
The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of all currently known ligands of these receptors. Two different studies have provided conflicted domain boundaries.
Statistics
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PSSM-Id: 517244
Aligned: 25 rows
Threshold Bit Score: 198.299
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8JUT_C       149 LGDPRLEKLWHKAKTSGkFSSEELDKLWREFLHYKEKIHEYNVLLDTLSRAEE-----GYENL-LSPSDMTHIKSDTLAS 222 Norway rat
6_pfamImport   2 FQDPQLNKLWLQTVSSKkFKTDELDKLLVEFKHHEDKVWELDELRKDLERVRA-----------ISENSVERFNDKQDQV 70 
XP_006629679 136 FDDPRLEKLWNKAKTSGkFSEEELKNLQREFQHHQEKIQEYNIVMDAVSRTEE-----IHKNV-ISPVE-ADVKTHALHE 208
XP_001373270 154 LDDPRLEKLWNKAKTSGkFSSEELDKLWREFKHHKEKVHEYNVLLETVSRTEE-----SHKNV-ISPLEENHVKEDVLHS 227
P55302       149 LGDPRLEKLWHKAKTSGkFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEE-----GYENL-LSPSDMAHIKSDTLIS 222 house mouse
4_pfamImport   2 LEDPRLEKLWHKAKTSGkFSRDELDKLWREFQHHREKVQEYNVLLETLSRTEE-----IQENA-INPSDMRHAQEEVLHS 75 
Q148K7       151 LEDPRLEKLWHKAKTSGkFSSEELDKLWRELQHHKEKVQEYHALLETLGGAEE-----SHENA-IGPVDLRGVQAEALAS 224 cattle
XP_015790064 140 FRDKKLDKLWQKAMDTG-FDEEQLKLLKEEFLHHQDKIDEYHRLITEHEIASIdtkkdELDNHlISFETTEKKTNITTGS 218
EEC15467     140 FKDKKLNKLWRKVEQSG-LDELELKTLKEEFQHHQDKIDEYYEILDGTVDSSGks-rnDHENS-LD-EVLSATEDASDAA 215
XP_029706887 134 FDDPRLDKLWNKAKSSGkFSNEELSSLKKEFQHHRDKIHEYNILIDAVSRTEE-----IHKNV-ISPLE-GDAKEPELHK 206 torafugu
8JUT_C       223 --------KHSELKDRLRSINQGLDRLRKVSHQGY---GpATEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKI 291 Norway rat
6_pfamImport  71 k-------REAEAKTLQEEVETSFQRLHLVAQKSKd--E-NVAFIEPRVAELWEMAQNGNFTVVELLSVKQELHHFENRI 140
XP_006629679 209 k--------HADLKEKMRNLNQGFERLRKISHQGFn--E-DSEFKEPRVIELWDMAKRANFTEDELDTLKEELSHFQTKV 277
XP_001373270 228 k--------HTELKDKLRSINQGFDRLRKVSHQGYd--T-NSEFEEPRVIDLWDMAKTANFTQKELDSFREELKHFEAKI 296
P55302       223 k--------HSELKDRLRSINQGLDRLRKVSHQGYg--S-TTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKI 291 house mouse
4_pfamImport  76 r--------HAELKDRLRRISQGYDRLRKVSHQGYg--A-EAEFEEPRVIDLWDLAQSANFSEKELEAFREELKHFEVKI 144
Q148K7       225 r--------HAELKDRLRSIGQGFDRLRRVSHQGYg--A-ETEFTEPRVLDLWDMAKSANFTEKELESFREELKHFEVKI 293 cattle
XP_015790064 219 m--------HQALEDKHFELKRNYEDLKTKVKDRTirpK-GKEFEEANVQKLWNLALAGDFTRDELESLRDELTHYQTRI 289
EEC15467     216 krlvenglPHAALKQHHQQLREGYEKLSARASQLA---G-MKDFEEEKVQQLWKLAQQADFTPTELNSLREELSHYEHRL 291
XP_029706887 207 k--------HTDLKQKMRDLNHGFERLRKLSHEGFt--E-DSEFREPRVIELWEAAKRANLSEDELDSLKEELHHFETKV 275 torafugu
8JUT_C       292 EKHNHYQKQLEISHQKLKhvesigdPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSr--aRHNEL 360 Norway rat
6_pfamImport 141 NKHKHFRDQLKNSAEKLDfh----gEGATEERVSRHQKLQGKVQDLGTKVKKLFGDLKSRLStv-iKHKEL 206
XP_006629679 278 EKHQHYQEQLELSHQKLKhvealgdKEHIQRNKDKYDMLSEKTREIGYKMKKHLQDLTSKITrtglRHNEL 348
XP_001373270 297 EKHHHYQKQLEISHQKLKhvegtgdKEHLSRNKEKYAMLEEKTKELGYKVKKHLQDLSTRISrg-lSHNEL 366
P55302       292 EKHNHYQKQLEISHQKLKhvesigdPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSr--aRHNEL 360 house mouse
4_pfamImport 145 EKHNHYQKELEISNQKLRhverfgdHEHLSRNKERYALLEEKTKELGYKVKKHLQDLSGRISr--aRHNEL 213
Q148K7       294 EKHNHYQKQLEISHQKLKhvesfgdQEHVTRNRERYATLEERTKELGYKVKKHMQDLSSRISr--aRHNEL 362 cattle
XP_015790064 290 KKLHFFEEQLNNERLTGKd------TVNQPDDVKVSSHIERKVKELNYKVDKVHNELEKRILk---RHVEL 351
EEC15467     292 RKLHHFRSELQLKADLTG--------GKLDTDPDEVKTLRQRVKQYNHKVGKLHGELEGRILq---RRTEL 351
XP_029706887 276 EKHSHYQEQLELSHQKLQhvealgdKEHIRKTQEKYNTLAEKTREIGYKMKKHMQDLSSKISgqglNHNEL 346 torafugu
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