8JUT


Conserved Protein Domain Family
Alpha-2-MRAP_N
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pfam06400: Alpha-2-MRAP_N (This model is not part of the current CDD release)
Alpha-2-macroglobulin RAP, N-terminal domain
The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of all currently known ligands of these receptors. The N-terminal domain is predominately alpha helical. Two different studies have provided conflicted domain boundaries.
Links
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Statistics
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PSSM-Id: 517243
Aligned: 19 rows
Threshold Bit Score: 118.215
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8JUT_C        31 IAGHGGKYSREKNEPEM----------AAKRESGEEFRMEKLNQLWEKAKRlHLSPVRLAELHSDLKIQERDELNWKKLK 100 Norway rat
Q16RX6        20 AEKAAEKYSKKANTLPDsev-----yqPDFRNIQRPYRMAKLNLVWSKAQH-RLTEPKLKSLYTELKIHDKEEIAWKQLN 93  yellow fever mo...
XP_001953595  23 ADKKGKKYSREANDPQNfrhvaeekydPDFKNIQRPFRIAKLNLVWAKAQN-RLTEPKLKSLYMELKIHDKEEISWKQLK 101
XP_002001132  26 DKRQSKKYSKEANSPHFkqvid-ekyePEIRNLQRPFRIAKLNLIWSKAQS-RLTETKIKSLYMELKIHDKEEIAWKQLN 103
XP_016665107  23 DENETLKKKLSLNNEPE----------FNVRQLNKPFKINKLNLVWSKAKQ-RCSEPELRSLLSELRIHDEDERELKVYK 91 
XP_046454864  28 CQAAVNKYSKEANQPEPvegv--dkdsW--KTIDKPFRLAKINLIWAKAQK-RLTEFKLKSLYSELKVQDKEELQLKRLK 102
XP_003773465  49 SWAHGSKYSREKNEPGTp----------PKREPGTEFRMEKLNQLWEKAKRlHFSPIKMSELNVDLKMQEKDELNWKKMK 118
Q99068        31 IAGHGGKYSREKNEPEM----------AAKRESGEEFRMEKLNQLWEKAKRlHLSPVRLAELHSDLKIQERDELNWKKLK 100 Norway rat
XP_063553158  28 PASHGGKYSREKNQPKP----------SPKRESGEEFRMEKLNQLWEKAQRlHLPPVRLAELHADLKIQERDELAWKKLK 97 
Q148K7        32 AAGHAGKYSREKNEPAP----------PSKREPAAEFRMEKLNQLWEKAQRlNLPPLKLSDLHTDLKIQERDEFKWKKLK 101 cattle

8JUT_C       101 veGLDGDGEKEAKLVHNLNVILARYGL----DGRKDTQ 134 Norway rat
Q16RX6        94 sqHKDKEGLKEAELRKKLIGIMSTYGLleyfDDTQDPE 131 yellow fever mosquito
XP_001953595 102 --QKDKNGLKEDELRRKLIGIMSTYDLlehfEETQNTE 137
XP_002001132 104 sqHKDKDGLKENELRQKLIGIMSTYDLlehfEDTQDVE 141
XP_016665107  92 tkNLDKDGEMESIVRKKLLGILERYKLsyhfDDTVNEP 129
XP_046454864 103 adNLDKDGLKEAEIRQKFGNVIERYGLadhfEKDTESN 140
XP_003773465 119 aeGLDDDGEKEAKLIRNFNVILAKYGL----DGKKDAQ 152
Q99068       101 veGLDGDGEKEAKLVHNLNVILARYGL----DGRKDTQ 134 Norway rat
XP_063553158  98 ldGLDEDGEKEARLIRNLNVILAKYGL----DGKKDAR 131
Q148K7       102 aeGLDEDGEEEAKLVRSLSVILAKYGL----DGRKDSR 135 cattle
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