1JG5


Conserved Protein Domain Family
GFRP

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pfam06399: GFRP (This model is not part of the current CDD release)
GTP cyclohydrolase I feedback regulatory protein (GFRP)
Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP).
Statistics
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PSSM-Id: 517242
Aligned: 12 rows
Threshold Bit Score: 121.345
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1JG5_A        1 PYLLISTQIRMEVGPTMVGDEHSDPELMQQLGASKRRVLGNNFYEYYVNDPPRIVLDKLECRGFRVLSMTGVGQTLVWCL 80  Norway rat
3_pfamImport  1 PYVLISTLIRLEIGPTIVGDEHSDVALMKELGATLHHRAGNPFKEWSVEDPPRIVLDKLEVLGYKLVGTTGIGQTAIWTL 80 
XP_003386516  3 QYVLITTQIRLENGPTICGDELSDPVLMAKLDAQLVRDAGNPFQVYSSPHPPRVILNKLACEGFRVVSMAGIGQTCIWTL 82 
EDO32067      2 PYILISTRIRLELGPTQCGDEWSDPELMALLDAELVHQFGNNFKEYLSKHPPRVVLNKLGKIGYKVISSTGIGQTIVWTL 81 
XP_002407323  2 PYLLVWSQVPGAA-PTYL-DGSQDPALLKELGGKVNKPVFSKRTLVKVDDTPCSVLNKLEVMGYKVLAVSGDTLGTVWTV 79 
EEC01832      2 PYLLVWSQVRGQL-PTYL-DGSQDPALLKQLGAKVTKPLMVKRATVHTDDSPGSVLNKLEGMGYKVVAVSGNPLGTVWTV 79 
Q6PBT6        2 PYILISTQIRLETGPTMVGDEYSDPSIMNYLGARKITVLGNNFSEYHVDEPPRLVLDKLDKIGYRVVSMTGVGQTLVWCL 81  zebrafish
XP_021411662  2 PYLLISTQIRLEAGPTMVGDEHSDPHLMSILGATKRTTLGNNFCEYYVNDAPRMVLDKLESLGYRVVSMTGVGQTLVWCL 81 
2_pfamImport  1 MH----TQIHTEVGPTPLGDGHSAPELMWYLGASKRSVLGNHFCEYFISDPPCMVLDKLECKGFHVLSKREVGWTLVWCL 76 
XP_004010500  2 PYLLISTQIRMEVGPTMVGDEYSDPELMQHLGASKRSVLGNNFSEYYVNDPPRIVLDKLERRGFRVLSMTGVGQTLVWCL 81 
Q6NVA8        2 PYVLISTQIRMETGPTIVGDEFSDTQLMAQLEADKRTVLGNNFSEYCVNEPPRVTLNKLEKLGYRVVSMTGVGQTLVWCL 81  tropical clawed ...
NP_001379909  2 PYILISTQIRMECGPTMVGDGESDPKLMGTLEAKLTKQLGNEFQEYITKWSPRKVLNQLEKEGWTVVAMAGIGQTCAWTL 81  Caenorhabditis e...
1JG5_A       81 HKE 83  Norway rat
3_pfamImport 81 HKP 83 
XP_003386516 83 YLE 85 
EDO32067     82 FKP 84 
XP_002407323 80 HKS 82 
EEC01832     80 HKS 82 
Q6PBT6       82 HKE 84  zebrafish
XP_021411662 82 HRE 84 
2_pfamImport 77 HKD 79 
XP_004010500 82 HKE 84 
Q6NVA8       82 HKE 84  tropical clawed frog
NP_001379909 82 YKc 84  Caenorhabditis elegans
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