Conserved Protein Domain Family
BID

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pfam06393: BID (488319 is an unknown moldel)
BH3 interacting domain (BID)
BID is a member of the BCL-2 superfamily of proteins are key regulators of programmed cell death, hence this family is related to pfam00452. BID is a pro-apoptotic member of the Bcl-2 superfamily and as such posses the ability to target intracellular membranes and contains the BH3 death domain. The activity of BID is regulated by a Caspase 8-mediated cleavage event, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, which causes a change of cellular localization.
Statistics
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PSSM-Id: 488319
Aligned: 13 rows
Threshold Bit Score: 240.734
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012664777   6 S-NGSGLRDEHLTGLLVYGFLQSCSNSGFQRELEELGHEPfvrthlLVRTHLHEELDe-----dELQTDGSRASRF---- 75 
XP_010589079   5 V-SNGSGLQNERITNLLVFSFLKNCPSCHFHEELAELSYE------LPLPAHLREEY-------DELQTDGNRNSHfhfq 70 
XP_005040440   3 Q-INGS----LQMEHALLFTFLDASSDCQFKDQLHSLHSP------Q--IMSCQASDd------DELQTDGNRSGH---- 59 
Q8JGM8         5 IySNGS----DHMERMLLFAFLAESSGCEFQEQLPSLQSQgv---lCSVKDALCYDSd------GELQTDGNRSGH---- 67  chicken
XP_005340634   5 V-SNGSDLRNEYITNLLVLDFLQSFSDCKFHQELRTLGQE------LPVRTYLEGERe------DELQTDGNRAS----- 66 
Q9JLT6         5 V-SNGSGLGAEHITNLLVFGFLRN-NDRDFHQELEVLGQE------LPVQVYLEGDRe------DELQTDGSRASRs--- 67  Norway rat
XP_003461816   5 V-GNGAGTRGELVTDLLVFGFLCSRDNSNFHSELKALGQE------LPGRPEV--DHd------DELQTDGNRLSH---- 65 
EHB13699       5 V-GNGAGFRDESITNLLVYSFLHTRNNSNFHPELEALGQE------LPVGVCLEADHd------DELQTDGNRGSRl--- 68 
P55957         5 V-NNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHE------LPVLAPQWEGY-------DELQTDGNRSSH---- 66  human
Q4JHS0         5 V-SNGSSLQDERITNLLVFGFLQSCPHASFHKELEVLGHE------LPVHTSGS----------DELQTDGNRCSY---- 63  pig
XP_035562808  34 V-SNGSGPQDERITNLLVFGFLQNCSNYNFHEELELLGRE------LPVPAYLKEDYd------DELQTDGNRCSY---- 96 
XP_015453936  29 I-SNGARLQHEHITDLLVFGFLQNCCNSNFHKELKALGHD------LPVPAYPREDYd------DELQTDGNRCSH---- 91 
XP_008248350  14 V-SSGPGPRDEHITNLLVLGFLQSCCSCSFHEELQVLGRE------LLSEAELADSYdccsyddDELQTDGNHASF---- 82 
XP_012664777  76 YAERIEADSGSQEDVIQNFARRLAQIGDSMDRSIPPRLVNNLVQQFRNPSLSEENRRGHLAAALEQVMQTCPADLTEEKA 155
XP_010589079  71 SFQGRLEQDSGSQEEVIQSIAERLAQIGDEMESQVHPSLVQNLARQFMDRNLSEEDRRKHLATAVDRVMQTCLLDMELEK 150
XP_005040440  60 FQNGELEL-PPTNEEVIRIIAAQLAEIGDQFDKEIQARVVRDLVQHFVNERLSREEITLHLSRAVNKLLTSIPSDMAQEK 138
Q8JGM8        68 LQNGELVPDPEVNEAIVRTIAAQLAEIGDQLDKQIKAKVVNDLVQHFLNENLPREEITRCLSQAVEGLARAIPSDLEQEK 147 chicken
XP_005340634  67 LFMGRIEADSESQEEVIQNIARHLAQVGDEMDRSIQPELVNELVARFMNAGLSEEDRSNCLDTTLKAAMQTYPKDMENEK 146
Q9JLT6        68 FYHGRIEPDSESQDEVIHNIARHLAQAGDELDHSIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTSFPRDMENDK 147 Norway rat
XP_003461816  66 FHGGRREADSESQEELIQHIASQLALIGDEMEHKIQASVVHQLSTQLRDSSLTPEGRRHCLAATLGEVMQTCPADVEQEK 145
EHB13699      69 LYGGRREGDSENQE-IIHSIAWHLAEIGDELDRSIQPGLVNQLAMHFRNPGLSEEGRRHYLAATVEEVMQTYATDMEQEK 147
P55957        67 SRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEK 146 human
Q4JHS0        64 FMEDAAETDSESQEAVIRDIARHLARIGDRMEYGIRPGLVDSLAAQFRNQSLSEEDRRQGLAAVLQQLVHSYPADMGQEK 143 pig
XP_035562808  97 FLDGGARD-SESQEEIIQDIARQLAQIGDRMDHSIHPGLVNNLAMQFMNVNLSEEDRRKHLAAALEQAMQTYPKDMEKEK 175
XP_015453936  92 IVLEREETESENQEEIIQNIARQLAQIGDRMDSRIPPRVVNYLAMEFMNVDLSEEDRKDCLSAALEEVMKTYPKDMEREK 171
XP_008248350  83 LQMGRAEAGSESQEEVIRNIARRLAQIGDRMDHHIQPELLNNLVVEFVN-DHSEEDRRRRLASAVEQAMETWPADMEREK 161
XP_012664777 156 TLLLIMLLAKKVADHTPSLLPVVFRTTVNFINRNLLASVRNLARNM 201
XP_010589079 151 KKLMLTMLLAKKVADHMPSLLRDVFRTTVNFINQNLLTYVRNLARN 196
XP_005040440 139 AMLVLAMVLTKKIVNTMPSLLRRVYDATVNYMNQQFHDYIVEMLGE 184
Q8JGM8       148 AMLVLAMLLTKKVANQMPSLLQRVFSTTVNYISQHFHNYIVRMLRE 193 chicken
XP_005340634 147 TMLIMTMLLAKKVANHTPSLLHDVFRATVNFINQNLFTYVRDLVRN 192
Q9JLT6       148 AMLIMTMLLAKKVASHAPSLLRDVFRTTVNFINQNLFSYVRDLVRN 193 Norway rat
XP_003461816 146 AVLIMTMLLARKVADHTPRLFRVVYDTVVDFINQNLLTYVRDLVRN 191
EHB13699     148 AKLITAMLLVRKVADHTPSLLRDIFHTTVNFINQNLLTYMRDLIRN 193
P55957       147 TMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN 192 human
Q4JHS0       144 TLLVLTMLLARKVAEHSPALLRDVFHTTVNFINQNLLTYLRNLVQS 189 pig
XP_035562808 176 TMLMLAMLLAKKVADHTPSLLRDVFHTTVNFISQNLLTYVRNLVRN 221
XP_015453936 172 TMLMLTMLLAKKVADHTPSLLRGVFHTTVNFINQNLLTYVRNLLRN 217
XP_008248350 162 ATLMLTMLLAKKLAEHTPSLLRAAFRAAVTLINQDLLAYVRNLAGN 207
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