Conserved Protein Domain Family
Calcyon
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pfam06387: Calcyon (This model is not part of the current CDD release)
D1 dopamine receptor-interacting protein (calcyon)
This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) and schizophrenia.
Links
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Statistics
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PSSM-Id: 517234
Aligned: 7 rows
Threshold Bit Score: 234.695
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006630385   1 MVKLGSNLAEK-PEKEQALEDG--FDNIPLITPLDVSQLQQPFPDKVIVKTTTEYQLQQKkkrKLYVP--GIKKLNINLY 75 
XP_040038005   1 MVKLGSNLQDK-GGKPVSVEDG--FQNVPLITPLDVGSLQSQAPDKVVVKTRTEYQTEKK---RLKVP--KVEEFTISFT 72 
P58821         1 MVKLGCSFSGK-PGKETGDQDGaaMDSVPLISPLDVSQLQPSFPDQVVIKTQTEYQLTSAdqpKKFADleGQRLACSHPE 79  Norway rat
XP_040043019   1 MVKIGSNLSDK-LEKQPSADDG--FDNIPLITPLEVNQLRQPFADKVIVKTVTQYQLQQKk-nKLYVP--NIKKLNINFY 74 
XP_003496676   1 MVKLGNNFAEK-GTKQPLLEDG--FDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKk-gKARPP--KIAEFTVSIT 74 
1_pfamImport   1 MVKLGVNVSEK---KAAGSEEG--FDTIPLMTPLDAAQLQIPPPDMVRRHRATDTHFYCY----WVSV--QLGLTSCSPR 69 
XP_064424564   1 MVKLGNNFSEKnNTKQPITEDG--FDTIPLITPLDVHQLQFPPPDKVVVKTKTEYNPDHKk-gKFRTP--KIAEFTISIT 75  coelacanth

XP_006630385  76 DEVSEKVKLTGLILITMAFLACLLLLVMYKALWYDQlSCPEGFVFKHKHCTPAALEMYYSE----QEPGARG----GLYT 147
XP_040038005  73 DGVSERLKVTILIILALAFLACIVFLVVYKAFTYDH-ACPDGFIYKHKRCIPASLEAYYAA----QDANSRG----RFYT 143
P58821        80 EG--RRLPTARMIAFAMALLGCV--LIMYKAIWYDQfTCPDGFLLRHKICTPLTLEMYYTE----MDPERHR----SILA 147 Norway rat
XP_040043019  75 SDVSDKAKITGLILITLAFLTSLLLLLMYKAMWYDQlTCPEGFILKQKHCTPAALEMYYTEqqeeQDPGVRGgvnaGLYA 154
XP_003496676  75 EGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDR-SCPDGFVLKNTQCIPEGLESYYTE----QDSSARE----KFYT 145
1_pfamImport  70 YTGITLEGMALLVVCALAFLVCVVFLVVFKVYQYEH----RGGVYRRG-CT-----SYYPP----QGPAGRG----RLFT 131
XP_064424564  76 EGVSERFKVTVLVLFALAFLTCVVFLVVYKVYRYDH-TCPDGFVFKNNRCIPAGLENYYSE----QDSNARG----KFYT 146 coelacanth

XP_006630385 148 AISHLTQAKKTIPELPSPWLPVINALKEAEKAKE 181
XP_040038005 144 VISHYSMAKQTTSHSVSPWLPGGAAGQQQQQQHD 177
P58821       148 AIGAYPLSRKHGTEMPAIWGNSYRAGKEEHKGTT 181 Norway rat
XP_040043019 155 ALSRLNQVKRTGPELPSPWLPVVSAPKEAEAAKQ 188
XP_003496676 146 VINHYNLAKQSITRSVSPWMSVLSEEKLSEQETE 179
1_pfamImport 132 IINHYNVAKHTTTRAVSPWLSITAEERRVSQLHT 165
XP_064424564 147 VINHYNLAKQTITRSVSPWMTVMSEEKVSEQETE 180 coelacanth
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