1M1E


Conserved Protein Domain Family
ICAT

?
pfam06384: ICAT 
Beta-catenin-interacting protein ICAT
This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions.
Statistics
?
PSSM-Id: 399405
Aligned: 19 rows
Threshold Bit Score: 73.1452
Threshold Setting Gi: 215506862
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1M1E_B         2 NREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLpphS-IDQGAE--DVVMAFSRSETED 78 
XP_011620288 114 DRDVIVGKLPRDVYTQQKMEILTALRKLGEKLTADDEAFLSENATATLSQFEKV---T-PNLGSE--DKIMALASSGVKT 187 torafugu
Q28D79       114 DRDLMVGKLGRDLYTQQKGEILIALQKLGEKLSPEDEAFLSENAGAVFNQFQKV---S-EGLGSG--DKVLALASIEVEN 187 tropical clawed...
EDO30486     114 QRDLKTGHMGQSVYTQQAIEILMALKKLGEQLKPEETEFLAANSNAALSSFEKV---A-ENSGAG--ASLLKVAGSQVED 187 starlet sea ane...
XP_003384318 114 QRDAKMGKITEDTLTQQKVEILVALRKLGEKLTAEELDFLSAHSTAALSQFEKI---SdADTAAG--EKVLAIAGTQVKk 188 Amphimedon quee...
XP_009858970  70 ERDFKIGKLVKDDYNQQKVEILTAVKKLGDTLTTEEQMFLSQNSSTSLSNFQNV---D----DSSeaTQVLAAAGNEIRS 142 vase tunicate
1_pfamImport   2 ERDFKIGKLVKDSYIQQKVEILTAVAKLGENLTPEEQSFMLQHSSTSLSNFQNV---D----ESSeaSNVLAAAEHDIRA 74 
EFX78975     111 QRDLKLGKLSSQAAQTQQVEVLGALKGLGEVLSTEEANILEKTNSASLQQFIKV---S-TDPESK--SKLLALAENslsl 184 common water flea
EGI61464     116 DRDVKLGKLNKEAAVRQRGEILSALRQLGEKLEPSELQLLERLSLNNIDTTRYV---Q-ITETAGkgKMALDVVGKEVKA 191 Panamanian leaf...
XP_004994217 114 DKQVSIGGISKESAIEQKVEILTALRQLGEQISPEEVQFLTQHSTAALDEFQRV---S-GELNAN----VLAKAGSQVQS 185 Salpingoeca ros...
1M1E_B        79 R 79 
XP_011620288 188 k 188 torafugu
Q28D79       188 T 188 tropical clawed frog
EDO30486     188 A 188 starlet sea anemone
XP_003384318     -     Amphimedon queenslandica
XP_009858970 143 Q 143 vase tunicate
1_pfamImport  75 Q 75 
EFX78975     185 q 185 common water flea
EGI61464     192 T 192 Panamanian leafcutter ant
XP_004994217 186 A 186 Salpingoeca rosetta
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap