Conserved Protein Domain Family
CART
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pfam06373: CART 
Cocaine and amphetamine regulated transcript protein (CART)
This family consists of several cocaine and amphetamine regulated transcript type I protein (CART) sequences. Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots.
Links
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Statistics
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PSSM-Id: 488308
Aligned: 12 rows
Threshold Bit Score: 105.157
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003452592  38 TQQEKELIEALQEVLEKLKGKQLPsSEKKLGWLAACDAGEQCAIRKASRIGKLCGCPRGTVCNFSVLKCL 107
XP_005798411  40 TQQEKDLIDALQEVLEKLRNKEMP-LEKKLGWLPSCDAGEPCAVRKGARIGTLCSCPRGTACNFYVLKCL 108
2_pfamImport   1 TQEEKELIEALQEVLEKLRNKQLPsSEKKLGWLPPCNTSEQCAVRKGARVGKLCGCPRGMECDFSILKCL 70 
XP_015198580  40 SSTEKELVEAMEELLGKVQS-RFPsYEKKAATIPMCDVGDRCALRQGPRIGKLCDCARGSICNSFLLKCI 108
Q1L893        37 QFIKRDLAEALDELLDGEQDNRIs-LEKKASVIPRCDVGERCAMKHGPRIGRLCDCMRGTACNTFFLRCY 105 zebrafish
XP_005808177  87 PAADRDLVEALEVLLGRIHS-RVSsTEKR-GSIPLCGMGGRCAVKFGPRIGKLCDCGRGANCNSYLLKCI 154
1_pfamImport   1 DGNERQLINDLHQVLERLQHNQFPaLRKKHSYLPACDPGEQCALRKGSRIGKLCDCSLPRTCNSFLHRCL 70 
KAG9272431    46 LTSEKQLLGALHEVLEKLQTKRIPpWEKKFGQVPMCDVGEQCAVRKGSRIGKMCDCPRGAFCNFFLLKCL 115
NP_001191710  37 RYNSNRLLGALHDVLERLQTTRINpWEKKYGQVPSCDLGEHCAIRKGSRIGKMCDCPRGAFCNFFLLKCL 106
XP_014340364  40 SSAERELVEAMEELLGKFQN-RYPtYEKKGGQIPLCAIGERCAVKQGPRIGKLCDCSRGSSCNSFLLKCI 108 coelacanth
NP_001074962  47 ASHEKELIEALQEVLKKLKSKRIPiYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL 116 house mouse
XP_006002380  38 SQEEKELIEALQEVLEKLKNKRVPsAEKKLGWVPSCDAGEQCAVRKGARIGKLCNCPRGTSCNFYILKCL 107 coelacanth
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