Conserved Protein Domain Family
Drf_GBD

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pfam06371: Drf_GBD 
Diaphanous GTPase-binding Domain
This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.
Statistics
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PSSM-Id: 399398
Aligned: 17 rows
Threshold Bit Score: 187.913
Threshold Setting Gi: 74856159
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001539243  257 FSQPkDDRIVDQMFYELMIKRgwqNLPEQAK---RQMLAYPASKKWTLVHQDHLTQAQGDkkksnsr--------ltygy 325  Histoplasma c...
Q54WH2        139 EEKK-RHDEIQKKFAQLVEQL---ATDSKAR---EGMMKLPYEARAQLVEQHRDKLANEKhpdeyvvllikeitrkniql 211  Dictyostelium...
Q10719        103 LLCPdDPNLVNELFDDVLKRLreeKSDSGEQfhwDANVTLSQENKWSFITGYLSRNDKFL-------------------- 162  Schizosacchar...
EAY14996       34 DGTV-NKDEILKMFDETIKEM---DLTGDQR---KPLDIKPIEEKWNFIVAQQQINSQQP-------------------- 86   Trichomonas v...
EAY20850       34 DGKM-DEEKVLEMFNDTITEM---DIHGEKR---KPLEAKPIEQKWNFVLLQNQLNRQLP-------------------- 86   Trichomonas v...
P48608         59 IQQL-SVAELDAKFLEIIEDM---NIPKDKR---EPLLAKSKEERQKMIMWHLKGKNSLE-------------------- 111  fruit fly
Q7Q1T1         55 THRL-SEAEVNKLFLEILEDM---NIPKDKR---DPLLGKPLEEKRKMIDMHVKGKISSE-------------------- 107  Anopheles gam...
O70566         90 sliL-SEKEVLDLFEKMMEDM---NLNEEKK---APLRKKDFSIKREMVVQYISATSKSIvgs----------------- 145  house mouse
AAI51785      111 pkPL-SEKEILELFEKMMEDM---NLNEDKK---APLREKDFSIKKEMVMQYINTASKTG-------------------- 163  cattle
CAJ81540       77 lQEL-EDDVVLQLFEKMLDDM---NLNPEKQ---QPLREKDIMIKREMVSQYLHTSKAGM-------------------- 129  tropical claw...
XP_001539243  326 pdGPAGLLSRADEDGSPEWYVKKVMDDSIST--------KQLQSLSVSLRTQPISWVQSFVEAQGPVALANVLSKINRRK 397  Histoplasma c...
Q54WH2        212 agGLQKSHSASNASLGSLSPVTPRVDDGLSV--------AELKNISVALRSRGLDWIHQFHKLGATTRLVELLSLYVNKK 283  Dictyostelium...
Q10719        163 --KISSNDSELNVKASVISYIEKLSCTPLKL--------KYVESLAVALRTESVTWVRYFLLMGGHIVLAKILQAIHEKK 232  Schizosacchar...
EAY14996       87 ---------------SPEYLTKLLKADNIVQsgkkerlsRILDRIAVFLKSSFLSWSTRFFKAKGHMILMSILTKKVATL 151  Trichomonas v...
EAY20850       87 ---------------APEYLIKVLKAHDVVQgankerlsAILDKLSVQLKSSILSWSTRFFNANGHLTLLSILSKKVACL 151  Trichomonas v...
P48608        112 -------RSANSRFEKPIDYVEYLQNGEHSThk----vyQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNA 179  fruit fly
Q7Q1T1        108 -------HRANSRFEKPSDYVQYLHEGDYLNrtn--kllACLESLRVALTSNPISWIKDF-GEDGINEIVSLLRYCKTVP 177  Anopheles gam...
O70566        146 kvLGGLKNSKHEFTLSSQEYVHELRSGISDEkl-----lNCLESLRVSLTSHPVSWVNNF-GYEGLGVLLDVLEKLLDKK 219  house mouse
AAI51785      164 -------SLKSNRQISPQEFIYELKMGSADErl-----fTYLESLRVSLTSNPVSWVESF-GHEGLGLLLDILEKLISGK 230  cattle
CAJ81540      130 --------SKKESSRSALMYIQDLKSGLGDNsl-----lLCLESLRVSLNNNPVSWVQNF-GAEGLSCLLEILKRIQDEQ 195  tropical claw...
XP_001539243  398 ASGpapatpasgDRDLDREYDIAKCFKALMNNKYGADNALE--CQQVIIALANSLTSPRLNTRKMVSEILTFLCH 470  Histoplasma capsul...
Q54WH2        284 SHT---------EESLQKQLECLNCIKNLMNNNVGIGYIFG--IKDSFKTIVLCLGSEYEKVNELAIGLLNTICF 347  Dictyostelium disc...
Q10719        233 HLK---------SPDITLEIAILKSMRCIIGQKIGTDFYLS--NKYPIDSVVHCLLSTKLLVRKLAAELLTFLCY 296  Schizosaccharomyce...
EAY14996      152 NGFep-----itQEDAECLINVLTCFRAICNTNSGIDIVMG--FPSIFPLFVNSIYPTLPRTVELACEILLVIIL 219  Trichomonas vagina...
EAY20850      152 NGYds-----lvREDADSLINVLVCFRAICNSNSGVKLMLN--YPNAFPLFVNSIYPDLPRTIETALQILVVLIL 219  Trichomonas vagina...
P48608        180 SYE-------------KIEFEAIRCLKAIMNNTWGLNVVLNpdQHSVVLLLAQSLDPRKPQTMCEALKLLASFCI 241  fruit fly
Q7Q1T1        178 RRM------------HKIEYECLRCLKAILNNSWGLNVILTpdQHAVVLLLAQCIDTTQPHTMCEAIKLLSALTL 240  Anopheles gambiae ...
O70566        220 QQE---------NIDKKNQYKVIQCLKAFMNNKFGLQRILG--DERSLLLLARAIDPKQQNMMTEIVKILSAICI 283  house mouse
AAI51785      231 IQE---------TIVKKNQHKVIQCLKALMNTQYGLERIMS--EERSLSLLARAIDPEQPGMMMDVVKLLSAVCI 294  cattle
CAJ81540      196 ASL----------RDVRSEHEIIRCLKAFMNNNFGIKAMLG--TEDGILLLARAVDRSVPAMMIDSLKLLSALCI 258  tropical clawed frog
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