Conserved Protein Domain Family
CD34_antigen

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pfam06365: CD34_antigen (This model is not part of the current CDD release)
CD34/Podocalyxin family
This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.
Statistics
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PSSM-Id: 517224
Aligned: 14 rows
Threshold Bit Score: 176.428
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_030865557 390 NYIILNMTENIDCEVFRQHRGPQLLALVEevlprhgsGHHGAWHISLSKPSEKEQHLLMTLVGEQGVvptQDVLSMLG-D 468
XP_007504399 388 NLLILKMTNFTMCDSPKDSRNHPLYVALCragkvnfnKDRDVCHVQLVPQPEKQEVAILNVSVQTHLq-pKELFEVLK-K 465
Q9R0M4       298 ELLILNLTRASLCERSPLDEKEKLVELLChsvkasfkPAEDLCTLHVAPILDNQAVAVKRIIIETKLs-pKAVYELLK-D 375 house mouse
XP_015203509 343 GYVILNMSENVDCDTFRVESGDRLLEMLEsafsrkmnSPQGSWFISLTKPNRQDKQLLMTLASEQGViptKEVLSMLG-E 421
XP_040060807 149 NAVNLKLKASSTCKDTKEKIGS-VLQELCg----------DGCKLDIYQEDDSDQIIVSGKYVEEDVagmADRFNNDNiK 217
XP_003474706 192 HSICLELNKTSSCEDFKKNTGEDLIQILCgkeeaeptAGTATCSLLLAQSEVQPQCLLLVFANSTEL---SGKISLLK-K 267
2_pfamImport   1 QGICLEQNETSRCEDFKKDKGEDLVQILCdek---eqAGAEVCSLLLAQSEIKPQCLMLFLPNRTEL---PSKLQFME-K 73 
3_pfamImport   1 QGICLELNETSSCEDFKKDKGEDLAQVLCreeqadakDGARVCSLLLAQSEVKPQCLLLVLANRTEI---FNKLQLLK-K 76 
Q28270       193 QGICLELNETSSCEDFKKDNEEKLTQVLCeke--paeAGAGVCSLLLAQSEVRPHCLLLVLANKTEL---FSKLQLLR-K 266 dog
XP_001234026 427 NYIILNMSDNIDCEEFRLERGPQLLALVEdafsrqtdGLQDHWLISLSKPNENDKHLLMTLAGEQGViptKDVLMALG-D 505 chicken
XP_030865557 469 IRRSLEEIGIQNYSTTSSCQARAsqvrsdygtlFVVLVVIGAICI--IIIALGLLYNCWQRRLPKLKHVSH-GEELRFVE 545
XP_007504399 466 RWDDLKALGVSNMTYGKESLDKDee------drFSLPLIITIVCMaaFLLLVAALYGCFHQRFSQRKDQQRlTEELQTVE 539
Q9R0M4       376 RWDDLTEAGVSDMKLGKEGPPEVne------drFSLPLIITIVCMasFLLLVAALYGCCHQRISQRKDQQRlTEELQTVE 449 house mouse
XP_015203509 422 IRRSLYEIGIQNYTSVTSCQSQPsqtrsdygklFVVLVIIGSVCV--VIIVSGLIYICWQRRLPKLKNMSH-GEELHFVE 498
XP_040060807 218 DKTDVQEAVPRWGREEEGGKN-------------SKLVLVSLLLTglLLAALLVAGYYFKTHR-RTSKGIRlAESFQVDE 283
XP_003474706 268 HKSDLEKLGIHSFREQDIGSHQS----------YSRKTLIAVVTSgiLLAILGTTGYFLMNRRSWSPAGERlGEDPYCTE 337
2_pfamImport  74 HRFDLQKLGIRDFTEENVLSHQS----------HSRKTLIAVVTSgiLLAILGTTGYFLMNRRSWNPAGERlGEEPYHSE 143
3_pfamImport  77 HQSDLRKLGIQGVTEQDVVSHQS----------YSRKTLIALVTSgiLLAVLGLTGYFLMNRRSWSPTGERlEDSKHYIA 146
Q28270       267 HQSDLKKLGIRDFTEQDVGSHQS----------YSRKTLIALVTSgiLLAVLGTTGYFLMNRRSWSPTGERlGEDPYYTE 336 dog
XP_001234026 506 VKRSLAEIGIQNYSTTTSCQSHPnqtrsdygklFVVLVIIGSICA--IIIVLGLIYNCWQRRLPKMKNMSH-GEELRFVE 582 chicken
XP_030865557 546 NGCHDNPTLDVASDSQSEMQEKHp--SLNGGGALNGPGSWGalmgGKRDPEDSDVFEEDTHL 605
XP_007504399 540 NGYHDNPTLEVM-ETSSEMQEKK---VANLNGEL--GDSWIvp-lDNLTKDDLDQEEEDTHL 594
Q9R0M4       450 NGYHDNPTLEVM-ETPSEMQEKK---VVNLNGEL--GDSWIvp-lDNLTKDDLDE-EEDTHL 503 house mouse
XP_015203509 499 NGCHDNPTLDVASDSQSEMQEKKp--SVN-GVAVDGGGSWHvl-vNKSAKEDAENLEEDTHL 556
XP_040060807 284 EN--QANTLVSVAPLPQEPHDKPt--AIGETPPENGTSAAP----ATNGHSATQTPVADTEM 337
XP_003474706 338 NS--GGQGYSSGPGASSEAQGKA---SVNRGAQENGTGQAT----SRNGHSARQH-VADTEL 389
2_pfamImport 144 SG--GGQGYSSSPGASPEAQGKA---IVNQGAQENGTGQAT----SRNGHSARQHVVADTEL 196
3_pfamImport 147 SWGRGSNWGSLPTHCSS-----RgflSVNRGAQENGTGQAT----SRNGHSARQHVVADTEL 199
Q28270       337 NG--GGQGYSSGPGVSPEAQGKA---SVNRGPQENGTGQAT----SRNGHSARQHMVADTEL 389 dog
XP_001234026 583 NGCHDNPTLDVASDSQSEMQEKKp--SVNGGNTINGPDSWDvl-iNKQASEDVDVFEEDTHL 641 chicken
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