4OEB


Conserved Protein Domain Family
Aegerolysin

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pfam06355: Aegerolysin 
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Aegerolysin
This family consists of several bacterial and fungal Aegerolysin-like proteins. It has been found that aegerolysin and ostreolysin are expressed during formation of primordia and fruiting bodies. It has been suggested that these haemolysins play an important role in initial phase of fungal fruiting. The bacterial members of this family are expressed during sporulation. Ostreolysin was found cytolytic to various erythrocytes and tumor cells. It forms transmembrane pores 4 nm in diameter. The activity is inhibited by total membrane lipids, and modulated by lysophosphatides. The potential use of aegerolysins is reviewed with special emphasis on their properties which would allow their use in therapeutics. Aegerolysin is part of the pleurotolysin pore-forming (Pleurotolysin) transporter superfamily. Member proteins assemble into a transmembrane pore complex.
Statistics
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PSSM-Id: 399391
Aligned: 18 rows
Threshold Bit Score: 103.949
Threshold Setting Gi: 75406765
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OEB_D           4 AQWVII-IIHNVGSkDVKIKNLKPSWGKLHADGDKDTEVSASKYEGTVIKP-DEKLQINACGRSDAAEGTTGTFDLVdpa 81  oyster mushroom
XP_001389418     7 AQWVHIrVVNSLSFdTLSVRNTWLGWGKFHKENNKSAEIPVSDINALRAAP-GGSFNVFACGRAHSPSGTEGSFDVY--- 82  Aspergillus n...
O32337          22 RQWVKFhI--EAVNeGLKIRNASLKWGKFHDPNNKDIPISPEDISKINIEK-HDTAIIASSGKENTASGTEGVFYIC--- 95  Paraclostridi...
O32338          22 RQWVKFhI--EAVHsNLKIRNASLTWGKFHDPYNKDIPISPEDISKINIGI-GRIEIIASSGKENTASGTEGVFYIC--- 95  Paraclostridi...
Q939R6           3 AREVHIdVNNKTGHtLQLEDKTKLDGGRW--------RTSPTNVA-------NDQIKTFVAESHGFMTGTEGTIYYSi-- 65  Bacillus thur...
MGH:PA14_01490   4 AEWIAVkVVVSKSIgTVGIRNATLQWGKFYRYTNKDDEISTEEVSSMNVQA-GSPQWIASCGRENASSGTQGSFDCY--- 79  Pseudomonas a...
O42717          11 AQWVII-ILHNVGSsPFKIANLGLSWGKLYADGNKDKEVYPSDYNGKTVGP-DEKIQINSCGRENASSGTEGSFDIVdpn 88  Agrocybe aege...
Q56QW9           3 AQWVII-LIHNVGQqNVKIKNLNASWGKLYADGDKDTEVPASKYEGMVIAP-GDQVQINACGREDAAEGTTGTFDLVdpn 80  oyster mushroom
EAA27128        63 YLEVDMtILNQASSgDLFIRNAHLNWGKWFEYPHTGDQLSHAQVEAKSASPnGGSMVVASSGRAWTPTGTEGHFDIY--- 139 Neurospora cr...
Q00050           8 AQWVTVhLINSMSSeTLSIQNASLSWGKWYKDGDKDAEITSEDVQQKTAPP-GGSVNVNSCGRSDASSGTTGGFDLY--- 83  Aspergillus f...
4OEB_D          82 DG-DKQVRHFYWDCPWGS-KTNTWTVSGSNTKWXIEYSGQN-LDsGALGTITVDT----LKK 136 oyster mushroom
XP_001389418    83 NG-DVRVAYIYWDCPWGS-KRNQFRVDRIADDYWVETGYWN-QSgGAIGSVTVEI----GRR 137 Aspergillus niger CBS 513.88
O32337          96 DEnEDKIAAIYWDCPWSG--SNKLTIDKYNTKFAIEQSPTMiSSsGAIGDVNLKV----SKI 151 Paraclostridium bifermentans
O32338          96 DEhEEKIVTVYWDCPWSG--SNKFELRDKNPNFIIETYPTMiSSsGAIGDVNIRV----FRR 151 Paraclostridium bifermentans
Q939R6          66 NG-EAEI-SLYFDNPYSG--SNKYDGHSNKNQYEVITQGGS----GNQSHVTYTIqtvsSRY 119 Bacillus thuringiensis
MGH:PA14_01490  80 DG-NTKMGTFSWDDPWKSgATNTWGFTPASADYAGITSGGN-ATgTDIGEVTLTL----GRF 135 Pseudomonas aeruginosa UCBPP-PA14
O42717          89 DG-NKTIRHFYWECPWGS-KRNTWTPSGSNTKWMVEWSGQN-LDsGALGTITVDV----LRK 143 Agrocybe aegerita
Q56QW9          81 DS-DKQVRHISWDCPWGT-KANSWVVGGSNSKWMIEYTGQN-LDsGALGTITVNT----LKI 135 oyster mushroom
EAA27128       140 HG-DTKVCHVYWDCPWSR-RSNSFEISEVDDNYAVEATGGS-LNkGPLGSITIEV----VKT 194 Neurospora crassa OR74A
Q00050          84 DG-NTKIGRVHWDCPWGS-KTNDFDVGERNKNYWVEIGTWN-KYgGAIGTVDVEV----GRK 138 Aspergillus fumigatus Af293
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