Conserved Protein Domain Family
HSL_N

?
pfam06350: HSL_N (This model is not part of the current CDD release)
Hormone-sensitive lipase (HSL) N-terminus
This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin.
Statistics
?
PSSM-Id: 517219
Aligned: 23 rows
Threshold Bit Score: 349.267
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q5R272         50 AYGTLYAACQDHAAFFARDHT------ELGQ-----RLHAAHIAWQDFIVLANRLVQQIAAFAHEYDFDEQTPGNGYRSF 118  Drosophila se...
XP_004363763  335 LLDEMLGLAQDNAAYFRNKATvkptfgSRPRaesaeRFEMLFFRAHSTVLAIRHDTFSLCWLAPLFDFDEHVKSSGYRSL 414 
P16386          6 MTQSLVTLAEDNMAFFSS---------QGPGet-arRLTGVFAGIREQALGLEPALGRLLSVAHLFDLDTETPANGYRSL 75   domestic cattle
XP_023200722    6 VFTALDKVCEENICVLSGPSE------SPYGtv-tkRLVACMRKIRQHGRALEPVVASFTAVYHHYDFDAQTPANGYRTL 78  
XP_003447301   12 VFATLEKVCQDNISVFCGPSR------LPHGta-veRLVTCVKQIQEHGRALEPIVTSFTAVYHHYDFDAQTPGNGYRTL 84  
1_pfamImport    1 VFSTLDSVCVEMISAISSQVS------LLSNna-tsQLLSAIGRIQEHSHAVEALVAGFTAVYHHYDFNAETPGNGYRTL 73  
XP_005159552    6 VFAGLQTICLDVISTLNGSSS------NSSNadaaeRLLGVMKQIQEHGRAVEPLITGFMTVYHHFDLDEQTPGNGYRTL 79  
XP_064425420    6 MFQVLHTLAEDNITFFRENSSet-----------grRFMAAFAKIQEHARSLEPIVHCFSRIYHIFDFDAQTPANGYRSL 74   coelacanth
XP_029695185   37 VFAALYSVCEENAAFFSGGVK------SSQGda-arRLVDVMNVIQEHARCLEPVICGFAAVFHHYDFDPHIPANGYRSL 109  torafugu
XP_029701313    6 VFTTLDTVCEDIISNMCAPSD------MPYGav-atRLVTCMKEIQEHGRVLEPVVAGFISVFHHYDFDAQTPGNGYRTL 78   torafugu
Q5R272        119 IYVTNACIAHGISICQQLTATRSTIFFRKKFYMKEVEACSQLL----SSLCTCLQYLLILRQWSaSTGD-----LFACGN 189  Drosophila se...
XP_004363763  415 VRVVMACLSKLAKEMRAFTLSRDSLLFRADASFVVMEDYIKTLellsAMLNIALRMASLGHSNSvFPGDaslgpLPASTL 494 
P16386         76 VHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAAL----TQLRALAYYAQRLLTTN-QPGR-----LFFEGD 145  domestic cattle
XP_023200722   79 VKVLQSCLVHIIHKGRYIASNCRGAFFRAEHNAAEMEAYCSAL----CQLRALLHLAQRLIHDN-AHGH-----LYSPQD 148 
XP_003447301   85 VKVLEACLLHIIHKARYIASSYSNPFFRVDHNTSEMEAYCSAL----CQLRALLHLAQQLINDN-DCGQ-----LYSLQD 154 
1_pfamImport   74 VKVVLSCLLHIIQKARYIASNCGGVFFRVDHNASEMEAYCTAL----CQLRALLYVAQRLLNDN-EHGQ-----LYSQEE 143 
XP_005159552   80 VKVVHSCIIHITHKARYIASNCTGAFFRMDHNVAEMEAYCSAL----CQLRALLYLAQVLLNDN-PNGQ-----LYSQEE 149 
XP_064425420   75 MKVVRSCVLYIIHKSRYVAANRRSIFFRASHNCAEIEAYCTAL----TQLRALVYFAQRLLTAN-RHGN-----LFFEED 144  coelacanth
XP_029695185  110 VKVVRCCLLHIIQKGRYIAANRRSIFFRVAHNAAEMEAYSNAL----CQLRALLYLAQRMLHDN-SHGD-----LFFQDE 179  torafugu
XP_029701313   79 VKVLQSCLFHIIHKGRYIASNCNSAFFRAEHNASEMEAYCNAL----CQLRALLHLAQQLLNDN-VRGE-----LYSLPH 148  torafugu
Q5R272        190 -HTAEQLFELGDTINQYCFYGRCLGFQYGDSIRGVLRFLGISMASYSESYYSQedDGPIVKTTRSLwtsgKYLMNPELRA 268  Drosophila se...
XP_004363763  495 -AAADSLLAEVEGIQCARFYGRKFGFQYSKPMRTTLKVILIAMASYSYGFNNN--KSDLAQKVFALasspLYVFGSEDRA 571 
P16386        146 eRVIADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRN--ETGISVTASSLftdgRFAIDPELRG 223  domestic cattle
XP_023200722  149 aDLSDRFVQEYSSMHKACFYGRCLGFQFSPALRPFLQTIVISMVSYGETYGRQ--QSGIGTAALSLltsgKYVINPELRG 226 
XP_003447301  155 eDLSRSFVQEYSSMHKACFYGRCLGFQYSPSIRPFLQTVVISMVSYGETYGKQ--QSGFGTAALSLltsgKYVIDPELRG 232 
1_pfamImport  144 -GLSEKFMKEYTSMHKACFYGRCLGFQVSNIMGSRL------MVSCD------------GVAALSVftsgKYVVDPELRG 204 
XP_005159552  150 gGLSERFVQEYISMHKACFYGRCLGFQFSPSLRPFLQTVVISMVSFGENYKKQ--QTGLGIAALSFftsgKYVVDPELRG 227 
XP_064425420  145 rGLSEEFVKEYTTMHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGENYRRH--ESGIGVAASSFftsgKYAIDPELRG 222  coelacanth
XP_029695185  180 sGLSESFVREYSTMHKGCFYGRCLGFQFTPAIRPCLQTLAIGLVAFGENYKRH--QSGIGVAASSFftsgKYAIDPELRG 257  torafugu
XP_029701313  149 tDLSRQFVQEYSSMHKACFYGRCLGFQFSPALRPLLQTVVISMVSYGEMYGKQ--QPGLGMAALSLltsaKYVIDPELRG 226  torafugu
Q5R272        269 RRIVNISQNAKIDFCKSFWFLAESEMMHKLPSIVGSSIKVNRLIELPAEPLKLPRrkdfkasenlssdvnqnqGDGDFVE 348  Drosophila se...
XP_004363763  572 RSLSKQLLRGDLAFSKAFWNLTENTMAKHVSKVVSANVSVNFVMKIPVVALTCPA------------------------- 626 
P16386        224 AEFERIIQNLDVHFWKAFWNITEIQVLSSLANMASTTVRVSRLLSLPPVAFEMPLt----------------sDPELTVT 287  domestic cattle
XP_023200722  227 AEFERITQNLDLHFWKSFWNVTESDILSGFTRIASNPVQVNLTLTVPPESLRLPLa----------------sDPRLSTS 290 
XP_003447301  233 AEFERITQNLDMQFWKSFWNLTESGLLSGFNRIASKQVQVNFTMTVPPVTLRLPLa----------------sDPRLSVT 296 
1_pfamImport  205 AEFERITQNLDMQFWKTFWNITETELISSLASITSNTVQVNLMLSVPGEPLSLPLa----------------sDPSLVVN 268 
XP_005159552  228 AEFERITQNLDMQFWKTFWNITETELLSGLTRITSSVVQVNVTLTVPAESLSLPLa----------------sDPSLSVA 291 
XP_064425420  223 AEFERITQNLDVHFWKAFWNITEMEVLTSLVNITSSTVRVNKVLSVPPNSFDLPLa----------------tDPNLMVT 286  coelacanth
XP_029695185  258 TEFERLTQNLDVHFWKTFWNITETEVLSSLASMTSTHVKVNRALSVPPVAFDLPLt----------------gNHRGSVT 321  torafugu
XP_029701313  227 AEFERITQNLDMHFWKSFWNLTESGLLTGFSRMASSPVQVNVTLTLPPVTLHVPLa----------------aDPRLTTT 290  torafugu
Q5R272        349 IPVPTAHLGPGlP--------------------VSVRLLSAKRRAGML 376  Drosophila sechellia
XP_004363763  627 -DDPSRY-----PaggnvhlsvetltndglfdvVHARLISHEWYAGQM 668 
P16386        288 ISPPLAHTGPG-P--------------------VLVRLISYDLREGQD 314  domestic cattle
XP_023200722  291 VSPPVAHWGPG-P--------------------VHMRLISYDLRDGQD 317 
XP_003447301  297 VSPPIAHWGPG-P--------------------VHMRLISYELREGQD 323 
1_pfamImport  269 VSPPVAHWGPG-P--------------------VNVRLISHALREGQD 295 
XP_005159552  292 VKPPVAHWGPG-P--------------------VNVRLISHVLRQGQD 318 
XP_064425420  287 ITPPVAHTGPA-P--------------------VQMRLLSYELREGQD 313  coelacanth
XP_029695185  322 IAPPSAHIGTA-P--------------------VLMRLISYDLREGQD 348  torafugu
XP_029701313  291 VSPPVAHWGPG-P--------------------VHVRLISCELREGQD 317  torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap