3LIU,4Q98,4JG5


Conserved Protein Domain Family
P_gingi_FimA

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pfam06321: P_gingi_FimA 
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Major fimbrial subunit protein (FimA)
This family consists of several Porphyromonas gingivalis major fimbrial subunit protein (FimA) sequences. Fimbriae of Porphyromonas gingivalis, a periodontopathogen, play an important role in its adhesion to and invasion of host cells. The fimA genes encoding fimbrillin (FimA), a subunit protein of fimbriae, have been classified into five types, types I to V, based on nucleotide sequences. It has been found that type II FimA can bind to epithelial cells most efficiently through specific host receptors. Human dental plaque is a multispecies microbial biofilm that is associated with two common oral diseases, dental caries and periodontal disease. There is an inter-species contact-dependent communication system between P. gingivalis and S. cristatus that involces the Arc-A enzyme.
Statistics
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PSSM-Id: 399375
Aligned: 32 rows
Threshold Bit Score: 56.8053
Threshold Setting Gi: 81314145
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LIU_B        17 AQLALAIkse-----egaVTKTGETTP----TdADVNTLTVGVFG--VDGWSVIytkdatpnSDGTKDVGPQ-------- 77  Parabacteroides...
WP_007665913  37 ARLELTLvgtp----adsRATGTLPTT----DeSQINRLTVAVFTgaSGNPVNAlre---ftGDDIKAATSGtgkk---i 102 Bacteroides int...
EDS13668      38 AQLELRLtgsgv--stkaTGSALPTQN----EeNTVKRFTVAIFNs----------------DESVNAIQTVtnnttpat 95  Bacteroides ste...
EDM19379      37 SNGNLALffeipnenhtrSAESSGVTEtgskDeYAVKSLTVYLFD--STTKSLKdqqelkniRQVKGEGRNIqyta---d 111 Bacteroides cac...
EDO12381      37 SNGNLALffeipnvatsrSAESSGVTTegskEeYAVKSLTVYLFD--STTKTLKdqqelkniNRAVTSGQNIqyta---d 111 Bacteroides ova...
EDS15299      34 TPITVNIkgna---dtraLTGEETGAT----NeNDINSLEFFVFN--SDGSFQKyykpasvaSDNQYTFLVN-------- 96  Bacteroides ste...
WP_004288816  36 AVLTIKLkgdgd--nqaqSRAAGPATDt---EdAVINNYLVFLFR--EGGALDCap-----yEGSSNAAATI-------- 95  Bacteroides egg...
WP_005658350  38 AVISIKVvgagn--nlaqSRAAGAAAT----TdAVINDYVAFTFR--EGGALDStpfyvrfdPNQPGDVEEPr------- 102 Bacteroides ste...
Q5LA50        35 ARVVLKLegd-----avdTRADVPATE----EgAKIKDITVFFFN--TTGFIVGtpkyigvaADIAKPITTT-------- 95  Bacteroides fra...
WP_008015971  48 IPMSIKM-----------GTRNATTDK----D-EVINSVRAIVFN--DKNELVY--------NDVSDASINVdsty--ta 99  Bacteroides
3LIU_B        78 --EVYAG-EAHVVVVANAap-------------------viQ-T-ELAKAKDIT---DFI--ETTINLSDE-TLT----- 122 Parabacteroides...
WP_007665913 103 tmLCEPGnGQTIYVVANAs----------------------T-G-LFAGVTNLA---GFK--AKLMLLSET-TKAag--a 150 Bacteroides int...
EDS13668      96 tiNCTPAtSCTGIVVANA-----------------------PtDgYFSGVLNKT---DFL--KRTIELGDAqt------k 141 Bacteroides ste...
EDM19379     112 riTVNPG-TYNIFAIAN----------------------------GKAINKEITmqdDFL--NAVDEVTYStGKIpnvpt 160 Bacteroides cac...
EDO12381     112 kiTVNPG-TYNIFAIAN----------------------------GKAITGNIStqeAFL--NAVDAVTYSaGKIpsvpe 160 Bacteroides ova...
EDS15299      97 -----AG-SLTILTAANQ-----------------------NlGePSPAPASLA---DFKksSSYKELSLD-GTN----- 138 Bacteroides ste...
WP_004288816  96 --TTGTTaAKKAYVVANTg---------------------aLaGgLFATVKTET---DLL--AVTGSLMDNtDNAstqtk 147 Bacteroides egg...
WP_005658350 103 -lGFGTTaAKKVYIIANVgp-------------------laD-S-PFANVKTEA---ELL--AVTGDLMEN-SNVttqte 154 Bacteroides ste...
Q5LA50        96 -----TD-ASQVVVIAN------------------------------LGGDETT---TGK--KLAGVSSID-QLKtkvfs 133 Bacteroides fra...
WP_008015971 100 siRAARG-YNNIYIICNEtselaeklaaitleneiekvtfsAvG-IVAPPPMYG---NVA--RAYVESRSD-GKNatvti 171 Bacteroides
3LIU_B       123 KGLTXSSKVLDVTLVANTTnyigyddevgd---------------------------------------------itvkd 157 Parabacteroides...
WP_007665913 151 GAATDTQKANNLPMLGSATgkdf--------------------------------------------------------- 173 Bacteroides int...
EDS13668     142 DCLPMSGDVKNG---DGNAtftl--------------------------------------------------------- 161 Bacteroides ste...
EDM19379     161 EGFVMTNRGAANLNIEIRkptd---------------------------------------------------------- 182 Bacteroides cac...
EDO12381     161 NGFVMTNRGAANLNVEVKkptd---------------------------------------------------------- 182 Bacteroides ova...
EDS15299     139 ---SRSDISTSLGFAMAAEgtanv-------------------------------------------------------- 159 Bacteroides ste...
WP_004288816 148 TNLWMSGESEVKfngg---------------------------------------------------------------- 163 Bacteroides egg...
WP_005658350 155 DNLWMSGVNDVSFSTSPDGyiyg--------------------------------------------------------- 177 Bacteroides ste...
Q5LA50       134 SVTTTTDPTTKHTINQTKDrlymsgmgk--------------------------------------------------vt 163 Bacteroides fra...
WP_008015971 172 NNIKMTELPVSVTRMVSRIsftaiknitnpnedfkvtkltvkvcrmpaatpieegraytediwsddltisgtgeldkngd 251 Bacteroides
3LIU_B       158 isgkevYGAGPVPLVR 173 Parabacteroides distasonis ATCC 8503
WP_007665913 174 --tagtETEANIALSR 187 Bacteroides intestinalis
EDS13668     162 --gagiNTGMTARLSR 175 Bacteroides stercoris ATCC 43183
EDM19379     183 ---sdkiTNVSISLER 195 Bacteroides caccae ATCC 43185
EDO12381     183 ---sdkvTSVSIGLER 195 Bacteroides ovatus ATCC 8483
EDS15299     160 --vegeTNKLSLSIRR 173 Bacteroides stercoris ATCC 43183
WP_004288816 164 -----tnaQVTVSLSF 174 Bacteroides eggerthii
WP_005658350 178 --------gtivSLNF 185 Bacteroides stercoris
Q5LA50       164 igsdglTGTATVNLHF 179 Bacteroides fragilis NCTC 9343
WP_008015971 252 yiikdnNYTIPDTVDF 267 Bacteroides
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