2EE7,7N6G


Conserved Protein Domain Family
CH_2
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pfam06294: CH_2 (This model is not part of the current CDD release)
CH-like domain in sperm protein
Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.
Links
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Statistics
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PSSM-Id: 517200
Aligned: 134 rows
Threshold Bit Score: 60.9184
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2EE7_A          20 LYLWVDNIPLSRPKRNLSRDFSDGVLVAEVIKFYF-PKMVEMHNYVPANSLQQKLSNWGHLnRKVLKR-LNFSVPDDVMR 97   human
12_pfamImport    1 VLRWLLSMELTYYPKNINRDFSNGFLLAEIFSIYY-PRDLKLITFENGNSIKSKLANWAQL-EKFFSK-KHFKIPKELIH 77  
A0DSG0          13 VAKWLDSLDLAYQVRNFRRDLANGFIVAEILSRYY-PKEVNIYTVYNEQNLDKKRDNWEQI-SKLLKK-KELQVPQEEYE 89   Paramecium t...
Q24IL2          11 IIQWLDSLDLAYQVRNVRRDLANGFVIAEILSRYF-PREVNIYTYDNGQRLERRRDNWEQI-SKLLLK-KSFLIAPEDYE 87   Tetrahymena ...
XP_001564185     5 VIKWVQSLDLSAPIQNPKRDLATGHLAAEIVARYSgTKYLDLHRLPNGAAAATKRDVWSQV-YRALQQlSCTTVTQPLID 83  
Q4D256           5 IIVWLQSLDLSHQVRHPQQDLSNGFTIAEIVSRYD-RR-VGMHSYVPGCSTECKRRNWKVL-LRDLKRlGCGSVTAEMAE 81   Trypanosoma ...
Q387Y3           5 VIRWLQSLDLTQQVRYPQQDLSNGFVFAEIASRYD-RQ-VGMHCYVPGCSAESKRSNWKVL-LADMKRiGFSAITKETAE 81   Trypanosoma ...
XP_009029502     9 VLKWVHSLDLTRNITNPQWDLSSGFIIGQMLYRYF-PNVVPLYRFHDGSKLEYRLFNWTLI-KQILNK-VGISVPTLMLD 85  
XP_018652346     8 VLRWLLTLDINLEHRNLKWCVSNGILVAEILHNYQ-PKTVDLGKFIDGQSIKVKLQNWDMI-QEILQR-LCICLPPDIIE 84  
XP_001348769     7 VIKWLHHLNISYSLRNIK-SASNGIIIAEILNIYI-PQSIHMNSLENGFSKEIKRKNWIII-KKVLTH-LNIHYDETAI- 81   Plasmodium f...

2EE7_A          98 KIAQCAPGVVELVL 111  human
12_pfamImport   78 GTLHSIPGVPEILI 91  
A0DSG0          90 PIFHQAPDAAQAFL 103  Paramecium tetraurelia
Q24IL2          88 PIYNQAPEAAYVFL 101  Tetrahymena thermophila SB210
XP_001564185    84 AVLQREPNAALTVL 97  
Q4D256          82 ATIQGKPGVAAMVL 95   Trypanosoma cruzi
Q387Y3          82 SIAQGKPGAAITLL 95   Trypanosoma brucei
XP_009029502    86 ATAHCKFGAARMTL 99  
XP_018652346    85 CAAHNKRNAGIILL 98  
XP_001348769    82 --INSEKNEIVKLF 93   Plasmodium falciparum 3D7
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