Conserved Protein Domain Family
MUN

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pfam06292: MUN (This model is not part of the current CDD release)
MUN domain
This entry corresponds to the MUN domain found in Munc13 proteins. These constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. Structural studies have defined MHD1 and MHD2 to be part of the larger MUN domain which forms an elongated structure composed of any pairs of alpha helices.
Statistics
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PSSM-Id: 517198
Aligned: 16 rows
Threshold Bit Score: 441.136
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN64439       497 TVVKDCVKACLRSTYQFLFENCYDLy------------------------------------NREF-QADPNEAKRDS-- 537 
EDO45421       697 NEIRKCLQKAALVNYTRVSAYAq--------------------------------------------IEGISVRKKSSsr 732 
11_pfamImport    1 KLVQRCLEQAAQINYSQLIEYAk--------------------------------------------IKV---------- 26  
10_pfamImport    1 NLVRRCLQEAARLNYSQLLQYAh--------------------------------------------IKG-STIKERRpl 35  
6_pfamImport     1 VV--DCFKPRLTSPYEF-FNTCLELf------------------------------------NRQF--PTRRSTEQEE-- 37  
7_pfamImport     1 SVVRDCVKACLKSTYEYIFNNCQELfnhqfqpadqsppepkkkkkkqddgqtgeedeeqdeeLEEGeEEEKECLPPEE-- 78  
NP_001358118  3667 QVVKDCVKACLNSTYEYIFNNCHDLy------------------------------------SRQY--QLKQELPPEE-- 3706 human
XP_002124363   846 QVVKDCCKACIRSTYGYVFSNCSEI-------------------------------------SQTD--KT-EEGPEEG-- 883  vase tunicate
Q8BYR5         802 KVVRKCLEKAALINYTRLTEYAk--------------------------------------------IEE-----TMN-- 830  house mouse
XP_029681770   804 GVIRKCLEQAAQLNYQRIKEYAk--------------------------------------------IEV-EKGQKDQkd 838  torafugu
EFN64439       538 ---------------------DdhGPRLDSLDFWHKLIALIVSVIEEDKN-SYAPVL----------NQFPQELNIGQLS 585 
EDO45421       733 phpcycsifkfrilhkentgkRkdAPPDKRLDDIMHLAELCIDLLQQNEE-HHA-------------EALAWVADLMAEH 798 
11_pfamImport   27 ---------------------DhqAPPEKRLEDMMRLGELCIEVLQQNEE-HHS-------------EAFSCWPELMAEH 71  
10_pfamImport   36 ----------------------rlRTSERRLEEVLRLGELCLDVLQQNQEhHHANPAaanpl-lwrlQAFSWWPELMTEH 92  
6_pfamImport    38 ---------------------Q--GPSIQNLDFWPKLITLMVSIIEEDKN-SYTPII----------NQFPQELDVGKVS 83  
7_pfamImport    79 ---------------------Q--GPSIQNLEFWPKLITLIVSIIEEDKN-SYTPVI----------NQFPQELDVGKVS 124 
NP_001358118  3707 ---------------------Q--GPSIRNLDFWPKLITLIVSIIEEDKN-SYTPVL----------NQFPQELNVGKVS 3752 human
XP_002124363   884 ------------------------GPRIDDLDFWTQLITLMVSVIEEDKN-IYTNYL----------NQFPSEFNVGQVC 928  vase tunicate
Q8BYR5         831 ---------------------Q--ATPARKLEEVLHLAELCIEVLQQNEE-HHAEGR----------EAFAWWPDLLAEH 876  house mouse
XP_029681770   839 p-----------------envGrlVTPAKKLEETIRLAELVIEVLQQNQE-HHAEAAvtgsgdqsgkEAFAWWTDLMVEH 900  torafugu
EFN64439       586 AATMWSLFAVDMKYALEEHEQHRLCKSSAYMNLHFKVKWLHANYVKDVPPYKGA--VPEYPAWFEPFVMQWLNENDDVSL 663 
EDO45421       799 QEIFWSLFSVDMDAALAVQ------LPDTWDS--FQLFQLLNDYLSNEPSLQrgkfhLHLRETFAPLVIRYIDLMESSIA 870 
11_pfamImport   72 AEKFLSLYRADMEAALQVQ------SIDSWNS--FPLFQLFNNFLRTDPHLCngmfhKHLQDLYIPLVVRYIDLMELAIA 143 
10_pfamImport   93 AETFLSLYRANMDAALQAQ------PIDSWNS--FPLFQLLNNFLRSDAHLSggsfhRHLQDVFVPLVVRYIDLMESSIA 164 
6_pfamImport    84 TEVMWRLFAQDMKYALTEHEKHKLCKTADYMNLHFKVKWLYNEYVKDLPTFTDA--VPEYPAWFLPFVLAWLAENEDVSM 161 
7_pfamImport   125 AEVMWSLYAQDMKFALEEHEQHKLCKTADYMNLHFKVKWLYNEYVKDLPAFADA--VPEYPSWFVPFVLAWLAENEDVSL 202 
NP_001358118  3753 AEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQ--VPEYPAWFEQFVLQWLDENEDVSL 3830 human
XP_002124363   929 AGEMWKMFSEDLEKGLLEHAQHRLCKTTDYMNLQFKVKWLYKEYVAPLDMFQDA--VPEYSQWFEPFTMDWLDVNEKLSM 1006 vase tunicate
Q8BYR5         877 AEKFWALFTVDMDTALEAQ------PQDSWDS--FPLFQLLNNFLRNDTLLCngkfhKHLQEIFVPLVVRYVDLMESAIA 948  house mouse
XP_029681770   901 AENFLSLYAIDMDAALEIQ------SPESWDS--FPLFQLLNDFLRLDYHLCngkfhKHLQDLYAPLVVRYVDLMESSIS 972  torafugu
EFN64439       664 EYLHGAFSRDK----KEGFQKSS-------------EHVLF-------------------------------SVSVVDVF 695 
EDO45421       871 QSVHKDFAKETwiav------------------------------------------------------gegCNSSEELF 896 
11_pfamImport  144 QSIHRGFQKETwqpl------------------------------------------------------nngSATSEDLF 169 
10_pfamImport  165 QSLHRGFQQETweplKPlsgvmvklrlkqintlfnyssilp-------mplphppsfslslirstvwpeangSATSEDLF 237 
6_pfamImport   162 EFMHGALERDK----REGFQQTS-------------EHALF-------------------------------SSSVVDIF 193 
7_pfamImport   203 EFMHGALERDK----REGFQQTS-------------EHALF-------------------------------SSSVVDIF 234 
NP_001358118  3831 EFLRGALERDK----KDGFQQTS-------------EHALF-------------------------------SCSVVDVF 3862 human
XP_002124363  1007 DFLSGAYERDR----RDSFQQSS-------------EHALF-------------------------------SCSVVDIF 1038 vase tunicate
Q8BYR5         949 QSIHRGFEQETwqpvKN-IANSL-------------PNVALpkvpslplnlpqipsfstppwmaslyestngSTTSEDLF 1014 house mouse
XP_029681770   973 QSIHKGFERESwepvKSltsnlpnvnlpnvnlqipkvpnlpvpvaglsvnlpqmpsfstpswmaaiydsdngSGTSEDLF 1052 torafugu
EFN64439       696 TQLTQCFDVVSKLECPDPEIWKRYMKRFAKTIVKVLVAYADIVKKEFPSHLKE---------ERIACILMNNIQQLRVQL 766 
EDO45421       897 WKLGALQQFISDLNWPDEVMEAHLIKRLKLMSADMVESCIKRTKERLDKWLSTtkfstdyviPSTVFVMMNVITQAKKQS 976 
11_pfamImport  170 WKLNTLQMFVMDLHWPEPEFAKHLEQRLKLMASDMMEACVKRTKSAFDAKMQKvckstdsllPVSVCTMFNVLIDAKNQC 249 
10_pfamImport  238 WKLDALQMFLADLRWPEPDFAKHLEQRLKLMAGDMVDACVRRTRAAFDVRLQKvggssdwrlPPSVCTMFNVLMDARRRS 317 
6_pfamImport   194 TQLNQSFEIIKKLDCPDPAVVAQYNRRFAKIFNLHLTLFLCSLSLSFKTESKK---------EKLPCMFRRNRAQLPRLR 264 
7_pfamImport   235 TQLNQSFGIIQKLECPDPAVVAQYSKRFAKTITKVLLEYCALLAKSFPSYCEK---------EKIPCVLMNNIWRMRVLL 305 
NP_001358118  3863 TQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTK---------EKLPCILMNNVQQLRVQL 3933 human
XP_002124363  1039 TQLNQSYDIIKKLECPDPQVVNQFMTKFAKTIEKVLDTYAEMVSKDFPKLCAK---------EDTACVLMNNIQQLRVLL 1109 vase tunicate
Q8BYR5        1015 WKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMIEACVKRTRTAFELKLQKankttdlriPASVCTMFNVLVDAKKQS 1094 house mouse
XP_029681770  1053 WKLDALQTFIRDLHWPEEEFARHLESRIKLMSSNMIENCVKRTRMAFESKLAKsskstdfriSPALCTMFNVMVDAKDQS 1132 torafugu
EFN64439       767 EKMFESM--GGDKLEEDAANILKELQQQLNGALDDLAMLFANSLEPRITVSVRELGDLLLAIKGggqvtlsqPAQRNNVT 844 
EDO45421       977 Q--ILCA---REESESEQHRYHSDVYEVLTGSQKDVAERIAEKLNSVLNALLHKLAR----------------------- 1028
11_pfamImport  250 S--KLCVldSEQEIDRQWQQYHSKIDVLIDEALKNIITSLVSKFAAVLNGVLSKLSR----------------------- 304 
10_pfamImport  318 S--KLCV---LDP--GQEQLYHSRIDVLIEETISDMISCLVTKFSTVLHGLLSKLSR----------------------- 367 
6_pfamImport   265 TRRFAAS--HVRELDTEAADILNELQVKLNTHLDNFSIVFAKSFQARINSCMRQMAEILYQIKG--------PPNHSTAE 334 
7_pfamImport   306 EKMFESM--GAKQLDTEAADILNDLQMRLSGVLDSFSTIFAKSFQGRINGCMRQMAELLYQMRG--------PPNRDTAE 375 
NP_001358118  3934 EKMFEAM--GGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGtgn---asPDARASAA 4008 human
XP_002124363  1110 ENLFRNM--GGEQLDSVTSDILKSLQVKLNVRLGELSEIFGQSFTQRIDNSIKAMGNLLCKIKGnani-siqQRSSDNIA 1186 vase tunicate
Q8BYR5        1095 T--KLCA---LDG--GQEQQYHSKIDDLIDNTVKEIIALLVSKFVSVLEGVLSKLSR----------------------- 1144 house mouse
XP_029681770  1133 A--KLCA---MEM--GQEKQFHSHIDELIEESVKDMIQLLVAKFVVILEGVLAKISR----------------------- 1182 torafugu
EFN64439       845 AEADDVLRPLMVL-----------------LDGSLSLYAESCEKTVLKRLLKELWKIVMRILEKTVVLPPMTDKSMMFkn 907 
EDO45421      1029 YDHGSLLSSVFALknp-----------gneMELNFTRFVKTNLSRVMKELSEERL------------------------- 1072
11_pfamImport  305 YDEGTFFSSVLSFtkp-----------rvdLADTYISFVRQNQDILRHGVSDELY------------------------- 348 
10_pfamImport  368 YDEGTLFSSILSFtteaakqmpavpnpgsdLADAYIGFVRQNQDVLRAGVGEELL------------------------- 422 
6_pfamImport   335 ADADNMLRPLMEF-----------------LDGNLSIFADICEKTVLKRILKDLWKTVLSSLEKSIVLPQSNDSLGAQll 397 
7_pfamImport   376 ADADVMLRPLMEF-----------------LDGNLSIFADACEKTVLKRILKDLWKTVLCSLEKTIVLPQCNDSLGAQil 438 
NP_001358118  4009 QDADSVLRPLMDF-----------------LDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQli 4071 human
XP_002124363  1187 HEADNVLRPLMDL-----------------LNGSLEMFAKTCEKTVLKHVLKELWKLVVKSLETSIVLPPLNDITGSQll 1249 vase tunicate
Q8BYR5        1145 YDEGTFFSSILSFtvkaaakyvdvpkpgmdLADTYIMFVRQNQDILREKVNEEMY------------------------- 1199 house mouse
XP_029681770  1183 YDEGTLFSSFLSFtvkaaskyvdvpkpgmdVADGYVTFVRHSQDMLRDKVNEEVY------------------------- 1237 torafugu
EFN64439       908 ltdnaknlaanakiedmsklfknhmagkpdvknalsGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFL 987 
EDO45421      1073 ------------------------------------------------------------KKYIVKKWYTSMVMRICEWL 1092
11_pfamImport  349 ------------------------------------------------------------IETVFDQWYTDSMKAICVWL 368 
10_pfamImport  423 ------------------------------------------------------------LQRLFDRWFGASMEAVCVWL 442 
6_pfamImport   398 taa----------------------------kglsnLKSLQGGGEAKTLTPKQCIIIDAGLETIKQYFHAGGNGLKKTFV 449 
7_pfamImport   439 ta-------------------------------akgLSNLKGGGEAKTLTPKQCLILDAGLEAIKQYFHAGGSGLKKTFV 487 
NP_001358118  4072 ftaak------------------------elshlskLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL 4127 human
XP_002124363  1250 rnaak------------------------eisqfskFRDLAREDVSRNLSPRQCYILDASLDSIKQYFHAGGKGLRKNYL 1305 vase tunicate
Q8BYR5        1200 ------------------------------------------------------------IEKLFDQWYSNSMKVICVWL 1219 house mouse
XP_029681770  1238 ------------------------------------------------------------IERLFDQWYTATMNLLGTWL 1257 torafugu
EFN64439       988 EKSPELQSLRYALSLYTQTTDTLIKTF 1014
EDO45421      1093 SHRMSDSLHEYQLKTLLPITKEIPVLF 1119
11_pfamImport  369 TDRLDLQLHMYQLKTLIKIVKKTYHDF 395 
10_pfamImport  443 TDRLDLQLHSFQLRTLISVVKSTSRDL 469 
6_pfamImport   450 EKSPELASLRYALSLYSQSTDALIKTF 476 
7_pfamImport   488 EKSPELESLRYALSLYSQTTDALIKTF 514 
NP_001358118  4128 EKSPDLQSLRYALSLYTQTTDTLIKTF 4154 human
XP_002124363  1306 EKSEELQSLKYALSLYTQTTDSLIKTF 1332 vase tunicate
Q8BYR5        1220 ADRLDLQLHIYQLKTLIKIVKKTYRDF 1246 house mouse
XP_029681770  1258 TERMDQQLHVYQLKILIRITKKKYRDF 1284 torafugu
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