4GP3,4GP3,4GP3,4GP3


Conserved Protein Domain Family
Fascin

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pfam06268: Fascin 
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Fascin domain
This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture. Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. Members of this family are histidine rich, typically contain the repeated motif of HHXH.
Statistics
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PSSM-Id: 399343
Aligned: 17 rows
Threshold Bit Score: 86.2349
Threshold Setting Gi: 2498359
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4GP3_A    142 VNIYSVTRKRYAHLSARpADEIAVdrdvpwgvdSLITLAFQDQ---RYS--VQ-TADHRFLR--HDGRLVARPE---PAT 210 human
O14926    266 ANHRYVSVRQGVNVSANqDDELDH---------ETFLMQIDQE---TKKctFY-SSTGGYWTlvTHGGIHATATqvsANT 332 human
4GP3_A    268 ANERNVSTRQGMDLSANqDEETDQ---------ETFQLEIDRD---TKKcaFR-THTGKYWTltATGGVQSTASsknASC 334 human
Q9NQT6    271 KTGRFISVIYDGEVRAAsERLNRM---------SLFQFECDSE---SPTvqLR-SANGYYLSqrRHRAVMADGHpleSDT 337 human
4GP3_A    391 EHGFIGCRKVTGTLDANr---SSY---------DVFQLEFNDG---AYN--IK-DSTGKYWTvgSDSAVTSSGDt-pVDF 451 human
Q6AXQ1     24 AGTYLTFEAYKSTVTATaKSLGRR---------QTWELLVSNEhetQAVvrLK-SLQGLYLLceADGTVCYGKPrtsHHG 93  Norway rat
4GP3_A     20 GNKYLTAEAFGFKVNASaSSLKKK---------QIWTLEQPPDeagSAAvcLR-SHLGRYLAadKDGNVTCEREvpgPDC 89  human
O14926     20 TDRYLTAESFGFKVNASaPSLKRK---------QTWVLE--PDpgqGTAvlLRsSHLGRYLSaeEDGRVACEAEqpgRDC 88  human
AAH59601   19 ENRYLTAEAFGFKVNASaPSLKKK---------QIWTLEQDDQd--GQVvyLR-SHLGRYLAsdKDGKVSCEAEtkeNDC 86  zebrafish
NP_989128 259 gNGRNVSTRQGIDLSANqDEESDQ---------ETFQLEINKE---TKMcaFR-THTGKYWTlsNNGGIQASAStlnNSC 325 tropical clawed frog
4GP3_A    211 GYTLEFR--SGKVAFRDCEGRYLApSGPSGTLKAgKATKVGKDELFAL 256 human
O14926    333 MFEMEWR--GRRVALKASNGRYVC-MKKNGQLAA-ISDFVGKDEEFTL 376 human
4GP3_A    335 YFDIEWR--DRRITLRASNGKFVT-SAKNGQLAA-SVETAGDSELFLM 378 human
Q9NQT6    338 FFRMHWN--CGRIILQSCRGRFLG-IAPNSLLMA-NVILPGPNEEFGI 381 human
4GP3_A    452 FFEFCDY--NKVAIK--VGGRYLK-GDHAGVLKA-SAETVDPASLWEY 493 human
Q6AXQ1     94 CFLLRFHrnGKWTLQCIISGRYLE--SDGQDVFC-NSRVLSAYHMWTP 138 Norway rat
4GP3_A     90 RFLIVAHddGRWSLQSEAHRRYFG--GTEDRLSC-FAQTVSPAEKWSV 134 human
O14926     89 RFLVLPQpdGRWVLRSEPHGRFFG--GTEDQLSC-FATAVSPAELWTV 133 human
AAH59601   87 RFLIVAQsdGRWALQSETYLRFFG--GSEDYLSC-FAQTIGEAELWAM 131 zebrafish
NP_989128 326 YFDIDWC--DRRITLKGVNGKFVT-AKKNGQLSA-SIDTPAETELFLM 369 tropical clawed frog
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