6FF7


Conserved Protein Domain Family
Isy1

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pfam06246: Isy1 
Isy1-like splicing family
Isy1 protein is important in the optimisation of splicing.
Statistics
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PSSM-Id: 399332
Aligned: 100 rows
Threshold Bit Score: 136.558
Threshold Setting Gi: 75036562
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6FF7_WW        1 MARNAEKAMTALARFRQAQLEEGKVKE----RR--PFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGL------GEF 68 
Q4QIU3        49 lARTKERKNTILYKLSKRRQEEERLARl--gVErlPTNPSEVDDEKIIKYVLFRLKQEIGDKTAQLRDQKLlsidrdGEA 126 Leishmania major
EGV61991       1 MSRNKEKAQSALNRYQQEVNRQAGVLEtnpnLR--PKYVQSVESLPQAEKWRSVVITEISTRLTRIQDPLL------EES 72  Yamadazyma tenu...
XP_001482604   1 MSRNTEKAQSALNRFQLAKSRSAGVLEsnpqLR--PKYVQLVKNLPQAEKWRSVVIGEISTNLTRIQDPNI------NHV 72  Meyerozyma guil...
Q6BU51         1 MSRNTEKAQSSLNRFQALKNKEAGVLEsnpnFR--PKYVQSVDSLPQAEKWRSTIIGEISVKLTKIQDPAL------NEY 72  Debaryomyces ha...
CCE81173       1 MSRNTEKAQAALNRYQALKNKEAGVLEsnpsLR--PKNVSSVTSLPQAERWRSIVIGEISVKQTQINDPIL------NDY 72  Millerozyma far...
CAY71246       1 MSRNSEKANSLLNRYHRQKNVLPVTGD----AR--PKRVQSVKDLRVAEKFRLLCVQEISQKISRINDVSL------NDY 68  Komagataella ph...
XP_001385616   1 MSRNKEKAQSALNRFQEFKNREAGVLEsnpsLR--PKRADTVNYLPQARKWKSVVMSEISTKMTDINDPNA------TEL 72  Scheffersomyces...
Q59R35         1 MSRNKEKAQSSLNRFY--QSQSSAPINyhyhQR--PKNIHSITQLSQAEGWRRSIIGEISKQLTEINDFEI------SDI 70  Candida albican...
XP_002550851   1 MSRNKEKAQSNLNQYYLQKDRVSGVLDsnsqNR--PKNVNKVTSLPQAEKWRSIVISEISINLTKINDENL------TDF 72  Candida tropica...
6FF7_WW       69 RIRDLNDEINKLLREKGHWEVRIKE-LGG---PDYGK----VGPKMLDHeGKEV------PGNRGYKYFGAAKDLPGVRE 134
Q4QIU3       127 VIRAKNDEVNKLLSRKYQWEARLSF-LAGepiAPRPR--------------KKI-------------FFGCAKELPEASV 178 Leishmania major
EGV61991      73 QIRELNETLNKLMSEKRAWEHHIKS-LGG---ADYLRf---G-PKFESM-GMMDndi---sgIKGFRYFGRAKDLPEVKL 140 Yamadazyma tenu...
XP_001482604  73 QIRDINEHLNKLFREKRAWEHHIKL-LGG---ADY----------------TLLsggdagIKVKGYRYYGRSRELPDVQE 132 Meyerozyma guil...
Q6BU51        73 QIRDINDSLNKLFNEKRSWEYHIKN-LGG---ADYMHf---N-KDFNNA-GKLSqldssgSHIKGYRYFGRAKELPDVKE 143 Debaryomyces ha...
CCE81173      73 QIRDLNDAINKLLREKRSWEYRIRE-LGG---PDYLSf---G-ANMGNA-GVYTgvdttgTKVKGYRYFGRAKELPELKD 143 Millerozyma far...
CAY71246      69 QIRDLNDELNKLTKERFAWEYHIKE-LGG---PNYI-------LNSNKA-MSSVnvd-----ssgYRYFGRAKDLPDVKQ 131 Komagataella ph...
XP_001385616  73 QLRDLNDKLNKLFWEKENWESQINI-LSG---GNPNR----I-RRNRRY-GQKApad--seyEPGYQFFGRARELPDAKK 140 Scheffersomyces...
Q59R35        71 KVRELNDQLNELFNEKRRWEYHIRDkLHG---NDYIRhngnTKNDLINT-GIRVnns---dkgKYYRYFGRAKDLPEVKL 143 Candida albican...
XP_002550851  73 EIREINDKLNLLFKEKKSWEYHIRNnLKG---NDYIK----YGKDLMNT-GVLVdrddnsV--KGYRYFGRAKELPDVKA 142 Candida tropica...
6FF7_WW      135 LFEKEP------------LP-----PPRK---TRAEL-----MKA-IDFEYYGY-------------------------- 162
Q4QIU3       179 VQKRQRvegmqeagedevADs---sEEDElvpDQLEAeqpatQDH----DY----------------------------- 222 Leishmania major
EGV61991     141 LQQAKIdka-------treSt---qQDTE---QREVQelemrFSN-LDPTYYSTftrtniydkaed-------------- 192 Yamadazyma tenu...
XP_001482604 133 MLKQTEeae-------kkkNs---qHSEK---QEFEVrlqkrRER-LGPFYYGCfdgdsssfptk--------------- 183 Meyerozyma guil...
Q6BU51       144 VLMLQQkkg-------hanKs---kHAKE---LEQNRllneqDQR-IKADYYGVydeindgnddiiasnerdiinq-vne 208 Debaryomyces ha...
CCE81173     144 MIAAQQnlk-------aanSn---rLKDH---EIKEKvlnerQAR-LTDEYYGLnepgsethncastrdtiqndl---sd 206 Millerozyma far...
CAY71246     132 MLEARKkhk-------teqEtqiqvAKDK---KLRLRlleesKEK-LPLSYFGVvnttv--------------------- 179 Komagataella ph...
XP_001385616 141 FLENERlek-------qrtSe---rKRKA---ESTDQsvkrlNQR-IDLAYYGYydedpcnfgtrnifnkqereqiiela 206 Scheffersomyces...
Q59R35       144 MIEENKknrknhkrddidDSd---qSKRR-----RKVdqyksTDNsIDMNYYGFydee---------------------- 193 Candida albican...
XP_002550851 143 LIEQKRkrtki---kqidYNe---dKARE---ER------------LGFAYYGYy------------------------- 176 Candida tropica...
6FF7_WW      163 ------------------LDED----------D-G---VIVPLEQEYEKKLRAELVekwkaerearlargekeeeeeeee 210
Q4QIU3       223 ------------------LERVkwlgssaadlD------LIRFEREAEAKMRAKGDsivsr------------------- 259 Leishmania major
EGV61991     193 ------dliaivgdvytrQEER----------K-N-------VEAYNFKAISKSLSddiqn------------------- 229 Yamadazyma tenu...
XP_001482604 184 -------kdvekelgytnEEKH----------Y-RidsELQAYEETRSQELGKELSenqe-------------------- 225 Meyerozyma guil...
Q6BU51       209 vlgdeiikpvddineyyvAHKA----------Q-GvdnLIE-FEKNRGKKLFRKFKnnqhndea---------------- 260 Debaryomyces ha...
CCE81173     207 alnsvsflsqdlgdnykmENKH----------Sn---tLLE-FENKRGIEILKSRSardrdgpas--------------- 257 Millerozyma far...
CAY71246     180 --------------eetsHTDA----------Q-GqdeELLEYESRLTTERRRKLNvqfsg------------------- 215 Komagataella ph...
XP_001385616 207 hklgeedfeiedetdygvRDDI----------E-NindRILRYEGCIKEERFYSSLddpsds------------------ 257 Scheffersomyces...
Q59R35       194 --------------edeyLDDS----------EaQlgdPLVVYEEKRTKELNDAEI------------------------ 225 Candida albican...
XP_002550851 177 ------------------DEKElpldiigfekKsTvsdPLLEFESQRSKELSEDTNdtqh-------------------- 218 Candida tropica...
6FF7_WW      211 einiyavteeesdeegsqekggddsqqKFIA---------HVP-VPSQQEIEEALVRRKKMELLQK 266
Q4QIU3       260 -----------------------agsgALILsycke----gkamIPDEEHFKQQLVNNRKKALQER 298 Leishmania major
EGV61991     230 -----------------------takdMTISqaqleeimdYSDiIPSEEDIKQWVLDQKKQQLLAK 272 Yamadazyma tenuis ATCC 10573
XP_001482604 226 ------------------------------------feghFEDlVPTSEQVSRWIVEERKRKLMER 255 Meyerozyma guilliermondii ATC...
Q6BU51       261 ---------------------------------dsnvitnFEKeVPTSDEVTKWIVNKKRAELIAR 293 Debaryomyces hansenii CBS767
CCE81173     258 --------------------------------ddvedivdFEKeVPTGEEVKAWIVQKKKAELINR 291 Millerozyma farinosa CBS 7064
CAY71246     216 -----------------------astrSddev----sllhLK--IPESSAIEKYIIQKKKEKLLSs 252 Komagataella phaffii GS115
XP_001385616 258 ----------------------------------imriqdFELeVPSSQHVQQWMLTKRKKELLAK 289 Scheffersomyces stipitis CBS ...
Q59R35       226 ---------------------------QQQDtenleqirmSFNdIPTNEVVTKWLVNKRREQLLSK 264 Candida albicans SC5314
XP_002550851 219 ------------------------------------nkiiNFDdIPTNEMVTKWLVNKKRQELLAK 248 Candida tropicalis MYA-3404
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