Conserved Protein Domain Family
ECSIT_N
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pfam06239: ECSIT_N (This model is not part of the current CDD release)
Evolutionarily conserved signalling intermediate in Toll pathway
Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1. It is part of the MCIA ((mitochondrial complex I intermediate assembly) complex, involved in the assembly of mitochondrial complex I. This is the N-terminal helical domain of ECSIT which adopts a TPR-like structure.
Links
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Statistics
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PSSM-Id: 517177
Aligned: 17 rows
Threshold Bit Score: 258.422
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EHA97297      42 EDLFQLApgGTRDKASFMKALQSFGQHNV-RKRGHVDFIYFALQKMPEYGVERDLAAYNLLLDVFPKEVFRPRNFIHTLF 120
XP_018654473  95 TEI------RKWKKRTFLHILEMFIQRSGpSRKGFTSFIQNALIKMPEYEVTDDLDCYKAVIRLFPTGRMTVKRFLQADF 168
XP_002102302  55 RNPFTAA--QDRTKNSYLTMVEIFQERDV-HRRNHVEFIYAALKNMADFGVERDLEVYKALINVMPKGKFIPTNMFQAEF 131
Q17B53        60 TPLFEHV--STKDKKTYIEMVRVFEGRSV-HRRNHVEFIYAALKHMEEFGVHKDLEVYKSLINVMPKGKFIPTNIFQAEF 136 yellow fever mo...
XP_005994181  86 DDLFKKAagDSRTKATFNRVVDTFCNKNV-RRRGHVEFIYAALKKMPEFGVERDINIYNRILDVFPKEVFVPQNFIQRMF 164
NP_001229867  86 DDIFDRAagDSKTKVEFNRVVDVFKSKDI-RRRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMF 164
XP_023201534  78 EDLFEQVakESKTKATFNQVIDVFTKRDI-RRRGHVEFIYAALKKMPEFGVERDLTVYNKLLDVFPKEVFVPRNFIQRMF 156
XP_002724302  73 EELFKQApgGERDKASFVRAVQCFGQQDV-RRRGHVDFIYLALRKMREFGVQRDLAVYNLLLDVFPKEVFRPRNVFQRMF 151
ELV14291      64 EELFRQApgEERDKASFVRAVRSFEQHSV-RKRGHVDFIYLALRKMREFGVERDLAVYNLLLDIFPKEVFKPRNVIQRIF 142
Q9QZH6        73 EDLFKPSgnRERDKASFLNAVRSFGAHNV-RKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIF 151 house mouse

EHA97297     121 FHYLLQQDCGVAVLHQMESNGVMPNKETEFLLLQIFGRQSYPMLKYMRMHLWFTRFLNINPFPVP----RDLPQDAVELA 196
XP_018654473 169 GHFPKQQQVMIDILNQMSRYHVLPDDEVGQMIIDVFGWRNHAMQTYRRLMYWMPKLYYSNPWTLPlriaDDLDLDPIKLG 248
XP_002102302 132 MHYPKQQQCIIDLLEQMEDCGVMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLP----DPVPDDTLEMA 207
Q17B53       137 MHYPRQQQVIIDLLEQMEDNGVIPDYEMESMLVNVFGKKGHPVRKYWRMMYWMPKFKNLSPWPLP----NPVPDDSLDLA 212 yellow fever mo...
XP_005994181 165 NHYPRQQECGVQVLEQMENYGIMPNKETKFLLVQIFGEKSHPVRKYQRIMYWFPKFKHANPYPVP----AVLPQDPLDLA 240
NP_001229867 165 NHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVP----HVLPSDPVDLA 240
XP_023201534 157 NHYPRQQECGVQVLEQMESYGIMPNIETKVLLVQIFGEKSHPIRKYQRIMYWFPKFKHVNPFPIP----QPLPEDAVDLA 232
XP_002724302 152 VHYPRQQECGVAVLEQMEQHGVMPDTQTEFLLTQIFGRRSYPMLKLVRMKLWLTRFKNVNPFPVP----LHLPPDPVDLA 227
ELV14291     143 VHYPRQQECGIAVLHQMESHGVMPNKETEFLLVQIFGRRSYPMLKFLRMKLWLTRFKNINPFPVP----HELPQDPVDLA 218
Q9QZH6       152 VHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVP----RDLPQDPLDLA 227 house mouse

EHA97297     197 TLGLQHMEP-DLSARVTVYQRPLPDDK 222
XP_018654473 249 CLIAERICP-DRMTEFTVVQMPSSNsd 274
XP_002102302 208 KLALERMCTvDLRSKITVFETSELKDA 234
Q17B53       213 KMAVERMCSvDLLSQITLFDTENVPDA 239 yellow fever mosquito
XP_005994181 241 KFSLQRIAA-DLDAKTTVFQMPATDIS 266
NP_001229867 241 QFSLTRIAA-DLDAKITIYQYPSTDIT 266
XP_023201534 233 VLSLTRIAN-DLDAKTTVYQLPFTDIT 258
XP_002724302 228 KLGLRHMEP-DLSARVTVYQMSLPSDP 253
ELV14291     219 RLGLQHMEP-DLSARVTVYQMPLSSDS 244
Q9QZH6       228 KLGLRHMEP-DLSAKVTVYQMSLPSDS 253 house mouse
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