Conserved Protein Domain Family
SLC52_ribofla_tr

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pfam06237: SLC52_ribofla_tr (This model is not part of the current CDD release)
Solute carrier family 52, riboflavin transporter
This family includes animal riboflavin transporters belonging to the Solute carrier family 52 (SLC52). They are plasma membrane proteins that transport vitamin B2 (riboflavin, RF) into cells. In case of infection by retroviruses, they act as cell receptors to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). These proteins belong to the MFS superfamily.
Statistics
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PSSM-Id: 517176
Aligned: 55 rows
Threshold Bit Score: 350.008
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_030836451   9 CDALTALLVVTFGTSTWVSLGGLWVELPLLTNlGIPEGYRIGSYLIIATQAAAIGPLIFVTCQC-LAPKNYHlEIPTIYA 87 
EEC19841      15 AKALMSVCSLMFGVSAWVSINGLWVQMPLLVP-RLPEGWNLGSILVIVIQVANLGPLAYTLARK-RRVGVVQ-VKAAVHA 91 
EDS25982      41 RSTLVDLLAILFGISAVLGHNANFVQLPLLVL-IAPEGLLLPSHLVVVSQFGNLGPLLYLALQK-LTACK---DSYLIYG 115
XP_002115951  17 ISWLTFTLVCIFSMSSWIGTNGIWVETPLLVA-RTPGGLQLPAVLTIISHLGAIGPACYGLAYY-YHPRRFN-EAPFIYI 93 
Q3LFN0         3 TFLFTFCLVAIFGSSSWIGTNSVWMELSLLTA-KLPEGWNLPSYLSAIVQIACLGPLIYSIIHK-GIKMTIP-TVPLIFI 79  Caenorhabditis ...
3_pfamImport   1 CSKATFILVALFGSSSWMGTNSVWMQLPLLTS-DLPEQWSLPSYLAGVVQIACIVPLIYTILHKgFKSFTIP-TPPLIIG 78 
EDO36685       1 --MATYFLVMMFGIGAWIAVNGLWVELPIIVQ-EIPESWSLPSYLTVIIQLANIGPLAFTLGNK-FLPRFVK-EIPVTYA 75 
XP_001635894  14 iswptYALVCLFGIGSWVALNGIWVELPIFVK-HAPEAWNLPSYLAIIVQLANIGPIVYGFGNH-WAKNVCN-EWTAIPL 90 
XP_003447314  13 HGLMALFAMGSWISVNSLWVELPVIVGVLPEG-WNLPAYLSVLIAFGNLGPIAVTITHHCAPGH-LNERLAI-HCIQILA 89 
XP_003976016  10 AVSHGLVAMFAMGSWISVNSLWVELPVVVNVL-PEGWNLPAYLSVLIAFGNLGPVVVTITHHCA-PGLLNER-LLIHCLQ 86 
XP_030836451  88 TLAVGATASFLLIFFWDSFSFWSG-DEHSIAFLILAFFMALVDSTSNLTFMPFISSLKSKYLNWYFIGEGLSSVIPSFVV 166
EEC19841      92 TLFVGLTAGVLLVFLWQET--VGG---HSVAFIALAFFLSMVDCTSSVLYMPFMARYPQQFLFWYMVGEGLSGLVPAGLA 166
EDS25982     116 LLVVNMVSTVCMAFWYDQTAYLFG-ENRSVVMLVCFLTASLVSCTSPVLFMPYMGRLRDVYMVSYLIGEGFSGFIPSVVA 194
XP_002115951  94 LLIVAVINSLALAIFWNKTFVAMStFEHSVALYFIAFIFSFVGCMSIVTFLPYMADYPEIYITGIFIGDGLSSLIPGIAI 173
Q3LFN0        80 FMVLACICQLGLCFFWDDTGYIFG-AIRSWPLYLLLFGLAIVDAISSVLFLPFMAQFHPSFLNAYFVGMGLSALIPSLLS 158 Caenorhabditis ...
3_pfamImport  79 LLVLACCCQLGLCFFWNFSSDVLG-VSRSWPLYALLFGLAIVNAMSNVLFMPFMAQFHPAYLNAYFVGMGLSSLVPSVLS 157
EDO36685      76 LVVIGVLASALLAHFWKETIYIAG-ADRSAALLILAFFLSMVDCTSSVAFIPYMSRFPMVYLSPYFLGEGLSGLLPSLVA 154
XP_001635894  91 IVTIGAVSCFLLAYFWDRTSLLFG-ANHSTALLALSFTLSLVDCTSSVVFLTFIGTFPAPYLTALFIGETLSGMLPSFVA 169
XP_003447314  90 VVASAFLAIFWCHTVTVAGEQRSV-PFLVLTFVLSFVCCTSNVTFLPFMFRYPPQYIRTFFIGQGFSALFPCIVALGQGV 168
XP_003976016  87 VLAVLASVLLALFWSHTVSIGGTE-RSLVFLLLTFVLSLVCCTSNVTFLPFMFCYPPEYIRTFFIGQGFGALFPCIVALG 165
XP_030836451 167 LIQGTGg---EDECVANHTFINitkdpntnvticqNCTVWAIERNGDA--LFPPQSYFIFIFVVLTLSTTSFCLLRSIpf 241
EEC19841     167 LAQGV-----DNKADNETTNAT-------------HGNATHAGGTVGP--RFSIEVFLSLLCVIVAISWAAFSVLAHL-- 224
EDS25982     195 LGQGVGg---NEECILNNSSD--------------PGAPEFISYTPPP--RFSSTVYFLLVFIFLAVCTVAFGILDKH-- 253
XP_002115951 174 LIQDVTdgpkCHHHLNISKANGt-------------------TVSENP--IFGPDTLFFIVFTFLLISLVSFTVLDHLps 232
Q3LFN0       159 LIQGTS----NYWCDDNKT-----------------------PHYYPP--RFSVSMFFLINFFFTCAAVAAFLVLYKIga 209 Caenorhabditis ...
3_pfamImport 158 LAQGSS----KYQCDENDM-----------------------AIRFPP--NFSVSIFFFAIFCFTCVALGAFLYLYQSga 208
EDO36685     155 LAQGVGegasNERCVAQPVYNS-------------SSNSTSGSWGPGP--RFTPKVFFWFLSVMMACCGLAFLALNTLqv 219
XP_001635894 170 LGQGIG-----DPCNSTLIQNTti----------lVNDFESTDLYVGKglKFGPEEFFFFLFSMMVVCGLSFLALNVLpf 234
XP_003447314 169 GKLECK----TVNGTVKPEYLK--------------------ENFPAQ--NFFWFLFVMLSISALSFLALTRRPSESQ-- 220
XP_003976016 166 QGVGKL----ECVNTNGTVKPI--------------------YLQENF--PAQNFFGFLCIMLTVSSLSFWALWQRQT-- 217
XP_030836451 242 frgqydEAEQYENSDETPGNVYESwcscc---ncctrRRDNDEITPLLSSYNTFEenktqdkrkatvhsncednlkfnee 318
EEC19841     225 ------PALKKEPSLKYGSNDNRGy------------VPEDGTDHVVPQVLEQPNgl----------------------- 263
EDS25982     254 ------PRSRAEYAQVTVKDGNDY-------------TYEQPKQEPNADSNEPSK------------------------- 289
XP_002115951 233 svriydRKIKKNIFRMQRDILNEAeiqlqarngvstsNETSDSESEQDGRCRRMKnrlftshindshyitpkmakfclpf 312
Q3LFN0       210 ----hkNSSQVEPEPKHSIQIIQG-------------DSTTDVNEVNTESSFQET------------------------- 247 Caenorhabditis ...
3_pfamImport 209 hthnsqYSKRDRKAPHEGTPLKHTvs----------gENEEPSSIDLHETGAPAIdgi--------------------vs 258
EDO36685     220 ----tkKQQVKEREYDVTTSDMHE-------------LQEISKTEAQSTSDIQVT------------------------- 257
XP_001635894 235 a---krQQILQRPDHRTNFSEVNR-------------HLLSENEFVSYGPHGSISs------------------------ 274
XP_003447314 221 ------QGSLPPPPQESDSGAAAKde----------eETHRLYNGGTPVSEEQVQv------------------------ 260
XP_003976016 218 ------MTLEDGQAQQSDNSGSER-------------PGEESHPLHHGGAPVPEGq------------------------ 254
XP_030836451 319 tCMGTEKDQNDnskmanivaSDISiekedvkgnsrpskssFSAGHAFLFTTLTLISALTYGVLPSIQGYSSAAYGSHIYL 398
EEC19841     264 eRAGPSNDPGKg--------DDLM----------------KRWQWNLALAMQSTIAALSNGVLLAVQTYSSLPYGQLPYH 319
EDS25982     290 ---------------------KVL----------------SQRSYHYLLVFLGVIFMIGGGFAPSVMPYSCLPYGNEVYH 332
XP_002115951 313 cEEASNANMETseserlstnQDRYqtdnesnkavewvshaDKQRYIILLLTEGWAFCISNGVLPSIQPFSCLPYGLKTYH 392
Q3LFN0       248 -SSIPDSSSA------------------------------TGARLAFLLLTTALVNAQMNGIVTSVQSYATLVYSQNTYH 296 Caenorhabditis ...
3_pfamImport 259 eLDETYRERSSichdadlhsVDYI----------------VGAKFAFLLFTTALVNAQMNGVITSVQSYATLPYSQATYH 322
EDO36685     258 --------------------DNIL----------------TTRQNVFLLVILAIVNGLSNGIIPAIQSYACIPYSYYIYH 301
XP_001635894 275 dTSAPDDEQVPpai----vyQPNC----------------SSRQVVYLLFVQVWINGLANGVLPSTQAYACQPYGSQAYH 334
XP_003447314 261 -EEQPPAQTFW---------TPRN----------------IFLLVLLAISNALTNGVLPSVQSFSCLPYGTMTFHLSVVL 314
XP_003976016 255 -KPVEEQPLTV---------TFWT----------------QPNVYLLSLLAVSNALTNGVLPSVQSFTCLPFGTVTFHLS 308
XP_030836451 399 LATTFAEISVPIGFFLVMIRPTT-SYPVVLLTSLCGVTAGGYCIVTASLSPTPPLQEQTFGQTLIVLAWIGQGLFFSYCR 477
EEC19841     320 LATNLATIANPLSCAVAGLLPVR-SLWALVLFTLGGLVCAGYILFLAVESPEPILVGTVTGAALMVLAWVAFVSLMTFVK 398
EDS25982     333 LSTALVLIANPVVAFLAMFLQTR-SIRMMHVLAAISLIFSAYTMITALMRPQPPLVGTTIGNIFVIVSWVGSVALLSYVR 411
XP_002115951 393 RTVASVAVTYPLSSVFAVLLFKYrSMTAVFYTSTLSRATGIFIITSAVMSPYPPLHNTVQGSILIVRQV----------- 461
Q3LFN0       297 YAVTLSNVISPLASYLQFFVKIR-SLPILAFLTLCSSLTTAVIIYLAALSPNWIFNSETAGTIISIASSLIAAGLHSYLR 375 Caenorhabditis ...
3_pfamImport 323 FAVTLSNVVSPLSSFLPFFVSVR-SIPVLGVLTACSTVMTAFIVYLASLSPNLIFNSQSIGSTLSIAGSLIAAGLHSYLR 401
EDO36685     302 LTLTLSNIANPITCLMFPLLRVK-SIPVITFLCGVYCVMCTYIIIIASQSPDVLLRCGDTGAALIVVISVSSVAMVTYCK 380
XP_001635894 335 LAVTLTSISNALTCVLALWLPSQ-STSIVTIFACIYNILSGYLLLLASLSPTPPLYNTLMGSIIMVTVSVVSGSLITYTK 413
XP_003447314 315 GNIANPVACFLAMFVVLRSSTPL-GFLALVGGVFAAYLMALAALSPCPPLLGSHAGVALVVISWIIFTGAFSYLKVVIGT 393
XP_003976016 309 VVLGNMANPLACFVAMFFVLRSL-SCLGVLSLGGGVFAAYLMALAALSPCPPLLGTSAGVALVVLSWILFTGIFSYVKVV 387
XP_030836451 478 ATIGLIL-RSDsgSRMS---MMCFGGCTTIGTMVGAAVMFPLVNVLDIFKS 524
EEC19841     399 SRLAAGMmSHG--GARS---LLWYGVATQGGSFVGALTMFFVTNYTHVFKS 444
EDS25982     412 VVAVTVL-RDH--GGKA---LVWAGAFTQFGTLIGSIVSFSVVNFTGLFQA 456
XP_002115951 462 --------RDK-------------------------------------FVK 467
Q3LFN0       376 VMFAALL-RE---GNQKesrLFWCGAFIQIGSFTGSAIMFPLVNVWKLFHS 422 Caenorhabditis elegans
3_pfamImport 402 VVFASLL-RE---GHQSesrLFWCGVFIQIGSFIGSAVMFPLVNVVHLFTS 448
EDO36685     381 VAISSLM-RNQ--GRKK---LLWFGISTQLGSCIGALSIFVPVNVYYMFKQ 425
XP_001635894 414 LTICTIM-KKK--GQRA---LFWCGVAIQAGSCIGALVIFPVVNVAKAFHQ 458
XP_003447314 394 LLHEAGH-AAL--LWCG---ISIQAGSLIGALVMFPLVNIYNVFTRGQECV 438
XP_003976016 388 IGSLLHE-AGH--TGLL---WCGISIQAGSLMGALTMFPLVNVYHAFASAQ 432
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