Conserved Protein Domain Family
SLAM
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pfam06214: SLAM 
Signaling lymphocytic activation molecule (SLAM) protein
This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognised as a receptor for measles virus.
Links
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Statistics
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PSSM-Id: 488214
Aligned: 11 rows
Threshold Bit Score: 189.571
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9QUM4         1 MDPKGSLSWRILLFLSLAFELSYGTGGGVMDCPV-ILQKLGQDTWLPLTNEhQINKSVNKSVRILVTMATSPGSKSNKKI 79  house mouse
2_pfamImport   1 MDPKGLLSLNVLLFLSLACDRSCGTVKSHVGCPT-IFGQLGSSVLLPLISE-GISKSMNKSIHMFITWAKSPGNRSSKKI 78 
XP_004775935   1 MDPKRLLSLNFLLFLSLAFELSCGTGESLLNCPE-IPGQLGNSVLLPLASG-GISKSMNKSVHVLVTRAESPGNSVKKKI 78 
NP_001265755   1 MDLKGLLSLNFLLFLSLAFELSCGTGESLMTCQE-VTEQLGRNLLLPLASE-GISKSMNKSIHILVTKSESPQKNVKTKI 78 
Q95MM9         1 MDSRGFLSLRCLLVLALASKLSCGTGESLMNCPE-VPGKLGSSLQLSLASE-GISKRMNKSIHILVTRAESPGNSIKKKI 78  dog
1_pfamImport   1 MDPRGLLSLNFLLFLFLAFELSCGTGEGLMNCPK-ILGRLGSSVLLPLTSQ-GISKSMNESIHILVAKAESQGSSVKKKI 78 
Q1RML5         1 MDPKGLLSSNVLLLFSLIIELSCRTGEGLTSSTKtILGQLGSSVLLPLASE-EISRSMNKSIHILVTMAESPKDTVKKKI 79  cattle
3_pfamImport   1 LRITFICSLSFILYTQCGHS---------MDCPK-IIQRLGSKLMLPLTYK-GINKSMSESIRIVVTMETSLGSIFKKKI 69 
XP_023372218   1 MDLKRLHSLTLLLFLSLAFEQSYGIVTGMMNCPK-TLHQLGRKVLLPLTHE-GINKSMDKSIHIVVTVATSPENSVKKKI 78 
XP_005339418   1 MDTKGLLSLSLLLILTLAFELSYATGGGVMNCPK-ILWPLGSDVVLPLTSE-RINKSMNKSIHILVTMAESPESSIKKKI 78 
XP_002715271   1 MDTKGYFSWSLLLVLSLAFGLSYVAGRGVMDCPK-SVQQLGSNILLPLTNE-RINKSMNKSIRIVVTVAKSPESSVKRKI 78 

Q9QUM4        80 VSFDLSKGSYPDHLEDGYHFQSKNLSLKILGNRRESEGWYLVSVEE 125 house mouse
2_pfamImport  79 VSLDLPEEGSSRYLEDGYKFYQENLNLEILESKKEHEGWYTMTLEK 124
XP_004775935  79 ASLDLPEGGSPRYLENGYTFHLENLSLGILESRKENEGWYFMTLEE 124
NP_001265755  79 VSLSLPERASPRFLENGYKFHPENLKLEILQSKKENEGWYFTTLEE 124
Q95MM9        79 VSLDLPEGGSPRYLENGYKFHLENLTLRILESRRENEGWYFMTLEE 124 dog
1_pfamImport  79 VSLSLPEGSSVGYLEDGYKFHLENLSLEIPESRKKDEGWYIMTLEG 124
Q1RML5        80 VSLDLRKGDSPR-LNDGYEFHLENLSLRILKSRKEDEGWYFISLEE 124 cattle
3_pfamImport  70 VSLDPSERSSPPNLEDRYKFHLESLSLEILKSRKEDEGWYSMTMEQ 115
XP_023372218  79 VSLDPSEGGPPHYLKDRYKFHLENLSLDILESRKEDEGWYFMTLEK 124
XP_005339418  79 VSLDPSEKGSPSYLEDGYQFHLENLSLVILGSKNDSEGWYFMSLEE 124
XP_002715271  79 VSLDLSEGGSPEYVEDGYRFHPEDLKLGLLESRKEHEGWYFLSLEE 124
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