8ESW


Conserved Protein Domain Family
GRIM-19

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pfam06212: GRIM-19 (This model is not part of the current CDD release)
GRIM-19 protein
This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homologue of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localisation and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity.
Statistics
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PSSM-Id: 517164
Aligned: 29 rows
Threshold Bit Score: 149.335
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8ESW_AO        9 PPKQDLPPPGGYKKIPFARVPPKSYFTGFTTIGTYVVVTAVGLGIYYLTAKKVKRDEIEMRSAQNVIFPILVAERDREFL 88  fruit fly
XP_002674998  39 ELNQDVAPQGGFPAVRVRRNSPNKFWSIGTFLFISTAVMAYGWYRYYKWIKKRDELKKEREVLELAMTPFLQAEHDIAFT 118
XP_020867468  19 PLLQDGPPPGGFAPVRYARRISNTGPSAMAIFLTVSGAFAWGMYQVGQGNKIRRALKEEKYAARRAILPILQAEEDERFV 98 
XP_024376005  19 PVLQDGPPPGGFPAVRYARRIANTGPSGVTVLLVSSAIIGWGMYQVGQGNIYRRGLKAEKIAARQAILPLIQAEEDARFV 98 
EDO40111       3 TIKQELPPKGGYAPLGFTKNLPKRGVSGWLTILGGAAVMTGGFAMVIRGNRQRCELRKEQLQARIALLPLLQAESDRRVL 82 
XP_005999477   5 KVKQDMPPLGGYGAIDYKRNLPKRGLSGYSMFGLGIGVLLFGYWKLFKWNRERRRLLIEELEARIALFPLLQAEIDRRAL 84 
Q95KV7         5 KVKQDMPPVGGYGPIDYKRNLPRRGLSGYSMFAVGIGALLFGYWSMMKWNRERRRLQIEDFEARIALMPLLQAEKDRRVL 84  domestic cattle
XP_007238486   5 KVKQDMPPPGGYGPIDYKRNLPRRGLSGYAMFGIGIGVMLFGYWRMFKWNRERRRLLIEELESRIAILPLLQAERDRQML 84 
XP_018645957   3 gYKQEMPPPGGFAPIDVSRKMPKGYVHGLITLGALYTSTYVGLKVLKYMKGKQTKINREDQECRIALAPFIIAEQERLYL 82 
XP_009032058   5 KYRQEMPPPGGYGMVDWAKKIPRKGMGGYAIFGAFFAVTTAGWVGYYFERKIKNKQRLEMNDARLAVAPLFVAEEQRMYL 84 
8ESW_AO       89 RQLRRNRDEEAELMKNVPGWEVGTWYGEPVFKTlPEDTLVTPIFKEFYAHSD 140 fruit fly
XP_002674998 119 LQRRAFLKKVEELMKGEPEFNAY----EKFYNS--TTRFQYPVYNaqlrhfk 164
XP_020867468  99 SEWKKYLEYEADVMKDVPGWKVG----ENVYNS---GRWMPPATGELrpdvw 143
XP_024376005  99 REKNKLLEEEAKVMANVPGWKVG----ENVYNS---GRWMPPSSGklgmds- 142
EDO40111      83 RGLKENEELEALIMKDVKGWNVG----ESVYHT---NKWVTPMPEQvl---- 123
XP_005999477  85 RLLRENLEEEAKIMKDVPGWKVG----ENLYHT---DRWVPPMTDELFNLRP 129
Q95KV7        85 QMLRENLEEEATVMKDVPGWKVG----ESVFHT---TRWVTPMMGELYGLRA 129 domestic cattle
XP_007238486  85 KMLRENLEEEAVIMKDVPGWKVG----ESVFHT---DRWVAPLSEELYNLRP 129
XP_018645957  83 KQLRKNREYEQNLMGDVAGWKIGHWFDYPVYHN-PRGLWCDPDINEFYAHva 133
XP_009032058  85 KRLRENRDEENELMKDVPGWETGKFEGQPVYHS-SHERFPYVDMKEYYAHSK 135
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