7YCX,8RBX


Conserved Protein Domain Family
COBRA1

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pfam06209: COBRA1 (This model is not part of the current CDD release)
Cofactor of BRCA1 (COBRA1)
This family consists of several cofactor of BRCA1 (COBRA1) like proteins. It is thought that COBRA1 along with BRCA1 is involved in chromatin unfolding. COBRA1 is recruited to the chromosome site by the first BRCT repeat of BRCA1, and is itself sufficient to induce chromatin unfolding. BRCA1 mutations that enhance chromatin unfolding also increase its affinity for, and recruitment of, COBRA1. It is thought that that reorganisation of higher levels of chromatin structure is an important regulated step in BRCA1-mediated nuclear functions.
Statistics
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PSSM-Id: 517162
Aligned: 12 rows
Threshold Bit Score: 520.837
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7YCX_f       107 PSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTElSVLHN 186 human
XP_002424304 102 KQLRPVVMCILRNTPHIDDKYLNILVRDRELYSDTDTEVKRQIWRDNQSLFGDEVSPLLSQYIQDKENILFDHL-NLNNL 180
Q16FI1       113 KALRPVVMCILRNTSHIDDKYLRILVRDRELYQDTDTEVKRQIWRDNQSLFGDEVSPLLSQYIREKEHILFDHM-NLNNL 191 yellow fever mo...
1_pfamImport   1 KALRPVIMGILKNIPHIDDKYLRVLVRDRELYNDTDTEVKRQIWQDNQSLFGDEVSPLLSQYIREKEDVLFDHE-NLTNL 79 
2_pfamImport   1 KQLRPIIMAILKNISHIDDKYLNVLVKDTELYKDTDTEVKRQIWKDNQSLLVNEVSPLLTQYIREKENILFDHN-NLTNL 79 
4_pfamImport   1 QTLQPIVMSLLKNLERIDDKYLKQIVADRELYEKCDLSVKRQIWQQHQGLFGDEVSPLFSAYIKEKDTMLFSLQ---SGS 77 
XP_001622497  98 KELRPVVVAVMKHLPKINDECLEHIANDAKLYEDCPIEVKRQIWSKHHHLFGDAVGPLLNQYIEAKYTLLHSTEaHNSHS 177
XP_003455080 106 PSIQPVVMQVLKHLPKVPEKKLKMVMADKELYKVCAVEVKRQIWQDNQALFGDEVSPLLKQYIVEKEAALFSSDlSILHN 185
5_pfamImport   1 PSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYIVEKESALFSTElSVLHN 80 
Q8WX92       107 PSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTElSVLHN 186 human
XP_002130034 104 DSLVPVSMCLLKHLPKVPEKYISVLTKDKSLYSACPIQVKRQIWQKNQTIFGDEVLPLLTRYIKEKEVVLLDGEcLEGNN 183
8RBX_v       140 PSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTElSVLHN 219 human
7YCX_f       187 FFSPSPKTRRQGEV---VQRLTRMVGKNVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMSLHDLDVGEICTVDPCH- 260 human
XP_002424304 181 FFSSSPKIRRQSEV---VQKLAHMIGTSVKLYDMVLQFLRTL--FLRTSNVHYCTLRAELLMALHDLEIQDIISVDPCH- 254
Q16FI1       192 FFTPTPKVRRQGEV---VQKLAHMIGNSVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMALHDLEVQDIISVDPCH- 265 yellow fever mo...
1_pfamImport  80 FFSPSPKVRRQGAV---VQKLAHMIGTSVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMALHDLEVQDIISVDPCH- 153
2_pfamImport  80 FFTPSPKLRRQGEV---VQKLAHMIGSSVKLYDMVLQFLRTL--FLRTHNVHYCTLRAELLMALHDLEIQDIISIDPCH- 153
4_pfamImport  78 FFAMTPKQRRQSEI---IQNLVKIIGRNVLLYDTCLQFLRTL--FLSTKNSHYCTLRVDLLMALHDADIQDITSMDPCH- 151
XP_001622497 178 FFSVPSKTRRQHAI---VQGLAKMIGKSLSLYNLVLQFLRTL--FLRANEVHYCTLRSELLMAVHDLEVKDIKDVDPCH- 251
XP_003455080 186 FFSPSPKTRRQGEV---VLKLTQMIGKNVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMSLHDLDISEICSVDPCH- 259
5_pfamImport  81 FFSPSPKTRRQGEXpppPHRLQGLSVRSLRASRTALLLLGSAspLLQSPREH--THLTSFLHCLASGDAQLWPSPDPAFs 158
Q8WX92       187 FFSPSPKTRRQGEV---VQRLTRMVGKNVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMSLHDLDVGEICTVDPCH- 260 human
XP_002130034 184 FFTSSPKSRRQGHV---VKTLTEMIGKNIRLYDMVLQFLRTL--FLKTHNVHYCSLRSEMLMSLHDLEVTEVCTVDPCY- 257
8RBX_v       220 FFSPSPKTRRQGEV---VQRLTRMVGKNVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMSLHDLDVGEICTVDPCH- 293 human
7YCX_f       261 -KFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLALST-------VRHLQELVGQETLP 332 human
XP_002424304 255 -KFTWCLDACIREKSVDIKRSRELQGFLDSIKRGQEQVLGDLSMTLCDPYAINFLAQSA-------IKILQHLIHNEALP 326
Q16FI1       266 -KFTWCLDACIREKNVDIKRSRELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSA-------IKILQHLINNEGLP 337 yellow fever mo...
1_pfamImport 154 -KFTWCLDACIRERNVDIKRSRELQGFLDSIKKGQEQVLGDLSMTLCDPYAINFLATSA-------IKILQHLINTEGLP 225
2_pfamImport 154 -KFTWCLDACIRERNVDVKRSRELQGFLDSIKRGHETVLGDLSMTLCDPYAINFLATST-------IRILHHLINNENLP 225
4_pfamImport 152 -KFAWCLDACIREQNIDPKRSRELQGFLEGVKRGQEQVIGDLSMTLCDPYAVNFLANKA-------IKIANNLINNENLA 223
XP_001622497 252 -KFTWCLDACIREKSIEGKRVRELQGFLEIAKNGEERVLGDIAMILCDPFAINTIAKSI-------IKLLHRLANTDTLP 323
XP_003455080 260 -KFTWCLDACIREKFVDGKRARELQGFLDGVKKGQEQVLGDLSMILCDPFACNTLVLSI-------MRNLQELLSQDALP 331
5_pfamImport 159 pQFTWCLDACIRERFVDSKRARELQGLQEGWLPGQ---------WLCGPRAALADAVGAvffpawlVKHLQELVGQEVLP 229
Q8WX92       261 -KFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLALST-------VRHLQELVGQETLP 332 human
XP_002130034 258 -KFTWCLDACIREHYVDVKRARELQGFLDNVRKGHEQVLGDLSMILCDPFAVNTMLWSV-------MKIIHELTVKETLP 329
8RBX_v       294 -KFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLALST-------VRHLQELVGQETLP 365 human
7YCX_f       333 RDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKL--------------PAEEK 398 human
XP_002424304 327 RDNTVLILLLRMLALGLSAWYMIDTQEFKEPKLDCQVVTKFMPALMSLMVDDQVRTLNSKL--------------PPDER 392
Q16FI1       338 RDNTILILLLRMLALGLSAWIMIDSQDFKEPKLDSQVVTKFLPALMSLMVDDQVRNLHAKL--------------PPDER 403 yellow fever mo...
1_pfamImport 226 RDSTVLILLLRMLALGLSAWVMIDSQEFKEPKLDSQCVTKYLPALMSLMVDDQVRALHNKL--------------PPDER 291
2_pfamImport 226 RENHVLVLLLRMLSLGLSAWVMIDTQDFKEPKLDSQVVTKFMPALMSLMVDDQVRALNTKM--------------PPDER 291
4_pfamImport 224 RENLVLMLILRMLNLGLHSWDILNSQVYREPKLDVELVTRFLPVLMSLIVDDQVRAVNSKL--------------PPDDR 289
XP_001622497 324 RTSEDITFLLRLLNLGVSAWDMIEKQAFKEILVNDELASKFLPFIMSLMVDSSLNTLNGKV--------------PEDDI 389
XP_003455080 332 RDSPDLMLLLRMLSLGQGAWDMIDSQVFKEPRLDLEVVTRFLPAMMSVVVDDHTFTVEQKL--------------PSEEK 397
5_pfamImport 230 RDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELVTRFLPMLMSFVVDDHTFNVDQKL--------------PAEEK 295
Q8WX92       333 RDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKL--------------PAEEK 398 human
XP_002130034 330 RESTELMLLIRMLKLGQSAWDIINKQIFKEPKVDVDISNKFIPCMVCIGVCEQSVLLRNKVknlrksvadcdvttPDDDQ 409
8RBX_v       366 RDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKL--------------PAEEK 431 human
7YCX_f       399 AP----VSYPNTLPES-------------FTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVE 450 human
XP_002424304 393 ESaitiIEHSGPAPDA-------------CQAYVTESSVASILAMYYTIHTAKLKDKVGLMRVLGILAT 448
Q16FI1       404 ESaittIEHSGPAPDA-------------VEAYIQESAVASILAMYYTLHTARQKDRVGILRVMAILAS 459 yellow fever mosquito
1_pfamImport 292 ESaittIEHSGPPPDA-------------CEAYMRESSVCGVIAMYYTLHAAKLRDRGALLRILSILGS 347
2_pfamImport 292 ESaitiIEHSGPVPDA-------------VQAYIQESSVACTVAMYYTLHVAKAKDRLALMRILGSLAN 347
4_pfamImport 290 ESaltiIEHSGPPPDL-------------YQKFITEDRLATELAIYYTLQVLRQKDRNAVVRVLGFLSN 345
XP_001622497 390 EEg--lVSDGRHLAQH-------------FMHMMVSNKVAFKLAWCFMLHLLHQKDKAAVFHALPWYVS 443
XP_003455080 398 SS----LSYPTTLPES-------------FNRYLQENRVACEMGLYYVLHIAKLRNKNALQRLLPALVE 449
5_pfamImport 296 AP----VTYPNTLPES-------------FTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLAT 347
Q8WX92       399 AP----VSYPNTLPES-------------FTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVE 450 human
XP_002130034 410 SKkkskPKKAADIGDEsndketssttinyIHKHIEKDQLCRIILMWFTLHLVKNKRKTQLIQVLPILGK 478
8RBX_v       432 AP----VSYPNTLPES-------------FTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVE 483 human
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