Conserved Protein Domain Family
PITH

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pfam06201: PITH (This model is not part of the current CDD release)
PITH domain
This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.
Statistics
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PSSM-Id: 517159
Aligned: 288 rows
Threshold Bit Score: 86.0982
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002291743   16 DDTSTALGTSLRPFINFSAVTCLNESI------L----G--AGKAIL------KYY--EDRRT-----VDPSLTSvdDAD 70  
CCG84849      131 PPVPSGSGGLLRALVDLEHSRALNATP------T----S--SIKAVL---------------Rps--fVGATVDS--AAG 179 
XP_002139259   23 NERVNPSEIDLDYCVNVRESFLLNC--------K----G--ELKHIL------------NMEN-----NLNPICS--DVD 69  
Q4UC69         26 ELNETRNLALQERCIDLTTSTALNVLD-----------GtfGLREIL-----------FSCSE-----SRNSMVS--DVD 76   Theileria ann...
XP_009031461  142 LTQNQLGARVTDDLIAVEKCRVLNMAP------K----Y--ELSNVI-------------KMG-----MKGYIES--HVG 189 
XP_002679108  485 SVVNTEHFKNLLAMIDLDKSLALNSDI--------------EMKRFLmlssitASV--SGKFT-----STYIAKS--NID 541 
XP_020428281  981 QSHVEGSLETLMSSVDLNKSFTVGVNK------Kl--sT--PLDRVL-----------SNEIS-----KTKHIQLvsDVD 1034
Q54GU2       1046 SKTGFNQSLEILQSIDFSKCGCVNIDKkqisqfS----G--SGAATAt----iTCWlgRVLNNeissdSTIFIQSidDS- 1114 Dictyostelium...
XP_003289991  890 NVTGINKSMEILETIDFNKCYCVNIDK------KsisaT--TPSNSIvsylgrLLNneAPPSD-----TDISIKS--IDD 954 
XP_018634946   46 QVNERLCVNLFEHFVDWTNVHCLND----------------SCQEPFp----sRDWraGRPRK-----GQRFVSS--ADD 98   Toxoplasma go...
XP_002291743   71 EdpELLLTIPFTEPVGIKSISILSyadapesargqSNATatttAAPRTIKVFVN-R-PN-LDFETVRDLE------PTAT 141 
CCG84849      180 P--TLLLYVALTAAVNVTKVKVSVp---------gAHLD----AAPSRIHIGTNvT-PApRDLMALARAe------TVQS 237 
XP_002139259   70 E--QMMIKLSFEEVVSITQFGIKAfk--------qSNQGqvicSSPKLVKLYVN-S-PL-SDFSEIEDMk------PCLT 130 
Q4UC69         77 P--QLILKLFFREPVCIDYLILRAnsk------peNLDA----SPPKTLQIYSN-R-PE-FDFSESDSID------PDQV 135  Theileria ann...
XP_009031461  190 S--QMLITVMFVNKINLGSFSVSA------------PED----CGPKLITLYYNsK-SN-PNFKDILNYR------HDEC 243 
XP_002679108  542 S--EIMFDIPFKQPLSLCSLLIRInn--------sTPKD----LEGISIKLFIN---QT-VDFVSIDSHkinqefkGKDL 603 
XP_020428281 1035 Q--QMLIHIQFNKQTKLNGLKLISt----------ISKE----TTPKVLKVYFN-Q-QS-VDFSSLQSLK------PAFS 1089
Q54GU2       1115 ---QLIINIGFKQAVKLTSIKFVSssn------rvPDRD----SVPKVIKIYTNnDqPN-IDFSVIESLT------PKCT 1174 Dictyostelium...
XP_003289991  955 S--QMIINIGFTKPVKLNTIHFVS------------EDPssssSVPNVIKIYIN-Q-PNsIDFSNVDSIK------ETTC 1012
XP_018634946   99 A--QLIIHIPFNRKVKLMGISLGI-----------HPDQv--qHGPSVIHLYKD-L-PT-FDFSDAVSv------kPLHT 154  Toxoplasma go...
XP_002291743  142 ITLIhpShqwe---------------------sehTGG-TI------------DYPLRPSg---RFQNVS-----EI-AL 178 
CCG84849      238 FTVY--Sdey-------------------------vgG-VT------------ELSLKPA----KFKDVT-----SL-TI 267 
XP_002139259  131 INFK--Qdd--------------------------teN-CQ------------MKILPGS----KFYRVK-----HL-TI 159 
Q4UC69        136 VELV--E----------------------------SDS-ET------------RVKLKGT----RFTHVK-----SL-QI 162  Theileria ann...
XP_009031461  244 FEYVfknt------------------------htfNFN-II------------ELAKKIL----TAEDLR-----RKaRI 277 
XP_002679108  604 IESI--Q-----------------------------AS-GC------------ELKLKLS----AFQNVS-----KL-SI 629 
XP_020428281 1090 FELD-------------------------------------------------ELSCSLIsdyqAFGQTKihqanSI-TL 1119
Q54GU2       1175 IEFS--Spsel--------------------esysSST-PF------------SFASGTTttntNFKSVN-----NL-TI 1213 Dictyostelium...
XP_003289991 1013 LNFEspDq---------------------------LKLcSK------------PYTFNPN----LYKSVL-----DL-TI 1043
XP_018634946  155 LHLL--PedlcrshdstaqspkpgnsgskrgsspfNSS-TLgpiasarnlpptAVPLPAL----LFGVTS-----SL-WL 221  Toxoplasma go...
XP_002291743  179 YFC-D-NYampdgfgassdlEDydeErvPTEITYVGLKGKG-TNV--KRQAVKAV-YETRG 233 
CCG84849      268 LID-E-NV------------SSr--D--VTRVSQVELFGTKv------------------- 291 
XP_002139259  160 FIQ-E-NQ------------DNv--D--TSFLNYIKIMGYVlAS----------------- 185 
Q4UC69        163 FIV-D-NS------------RDt--D--QTFLNELVIWGKV------HPN------YKSDF 193  Theileria annulata
XP_009031461  278 YFT-DcRS------------DNv--Q---KIIIYVQNNQKNtNKT--RIDALSFFmYKPDK 318 
XP_002679108  630 IIEnQvNT------------SM------QTSVEQLVVFGNVsTKTgsKLVKVSKKnYKKKD 672 
XP_020428281 1120 FVE-S-NH------------SSsddC--KSIIEKILVMDSVwSLK--INDDLNSScVSVTD 1162
Q54GU2       1214 FIE-S-NF--------------------SKNQDKVSIIEKI---------ILS-------- 1235 Dictyostelium discoideum AX4
XP_003289991 1044 LIE-S-NF------------SN---N--KNQISSLK--------------KIILS------ 1065
XP_018634946  222 FIE-E-NQg-----------GK---D--VTKISTMQVWGVPlQDM--DVK------HIRR- 255  Toxoplasma gondii ME49
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