Conserved Protein Domain Family
Peptidase_M90

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pfam06167: Peptidase_M90 
Glucose-regulated metallo-peptidase M90
MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase, whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.
Statistics
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PSSM-Id: 399282
Aligned: 108 rows
Threshold Bit Score: 217
Threshold Setting Gi: 503096522
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011516845                         9 LRARSKARkla---hyaIPDDLWAQTVAALPFVQRYDEADLTALRELATLFIANKEYSTAHdMELTDEMVVSVAAQACVP 85  Cupriavidus metallidurans...
WP_014782549                        18 YLQNKKRTae------pFPPAWKSLLIKHVHYYWELSETDKEKFRKRMMAFLSEVYIDAVD-TELVDLDKILIAASAVIP 90  Aequorivita sublithincola...
WP_013072779                        18 YRKAKRHSvk------pFPEHWHKLLTDNVLFYRNLSKDAQLIFQQKMMLFLSEVYIDAVQ-FELEELDKVLIAASAVIP 90  Flavobacteriaceae...
CDF79000                            19 LRKLKTKKad------kCPKHWHDLLLKHVDFYTNLSSKQQNQFQKRMMLFLSEVNIEGIQ-LELQELDSVLIAASAVIP 91  Formosa agariphila KMM 3901...
CCH01691                            22 WFLNRKRRstpaepaepLPPSLVELLAENVPYYATLPADRQAVFADRVSLFLAEVQVEGVD-TDVDDIDRVLVASSAVIP 100 Fibrella aestuarina BUZ 2...
jgi:Sph21_3673                      19 FIWSKRKRagrkgaqegLTETYNGILEQYVSFYRDLNDADQERFLNEITIFLRDVHIEGVG-TEVNELDRVLIASSAVIP 97  Sphingobacterium sp. 21...
WP_012792193                        14 iVLYMRRKkekqakdqtLAGIYKTLLNDHIRYYQLLDDKEKGRFEALVNEFLQYVRIEGVG-TEVTDLDKVYVAASAVVP 92  Chitinophaga pinensis...
WP_008509629                        15 yLLFRKKNaqvaatnltPHIVYQSLLNEHVRYYQKLDAAGKARFENKIAEFLAETRIEGVG-TDITDLDRVLIASSAVIP 93  Mucilaginibacter paludis...
WP_014021980                        18 fyWQRKKQnkwkvpsspFPTEWRSILMENIPYYRSLSSDDKQRFEYKIQEFLLNCKVTGVK-TEINLKDKILVASSAIIP 96  Cyclobacterium marinum...
WGS:AAXU:1101174000286_ALPR1_16838  20 iyKSKVKKsglk-vpelFPEKWRRFLESEVQFYSRLSPEEKSTFEADIQRFLKRIRITGVK-CEVTDEDRLLVASSAVIP 97  Algoriphagus machipongonensis...
WP_011516845                        86 ILKLGiE-WYRGWHGIVLYPGEFVirktiqedvgfEDIGL-VHGVEEEASGEAWE----HGPVILSWPDVaspgagldah 159 Cupriavidus metallidurans...
WP_014782549                        91 VFGFS-EwHYNNLSGIILYPDNFN-----------DDLEFdQSGESRIINGLVGSgr-fENQMILSRKALys-------- 149 Aequorivita sublithincola...
WP_013072779                        91 VFGFK-EwHYTNLSGILLYPDNFN-----------EDMQFsSKDNSRNIGGIVGNgr-fEKQMILSKKALyh-------- 149 Flavobacteriaceae...
CDF79000                            92 VFGFP-EwHYTNLSGVLLYPDNFN-----------SDYEFgSKKENRIIAGMVGTgr-lEKQMILSKKALyh-------- 150 Formosa agariphila KMM 3901...
CCH01691                           101 MFAFD-DwQYPNLTTVVLYESTFN-----------EAYQT-E-GDDRRIMGQVGTggalQSTMALSKSALrn-------- 158 Fibrella aestuarina BUZ 2...
jgi:Sph21_3673                      98 IFNFR-GwRYKNLSNIVLYPDTFN-----------SDFQF-V-GARRNTLGMVGEgf-mNGQMILSKSALhh-------- 154 Sphingobacterium sp. 21...
WP_012792193                        93 IFGFP-DwKYRNLTNVILYPDTFD-----------HNFQF-E-GDERNILGMVGSgy-mNGQMLLSRAALtk-------- 149 Chitinophaga pinensis...
WP_008509629                        94 VFGFP-EwKYQNLTNVILYPDTFD-----------QEFQF-E-GENRNILGMVGSgy-mNGQMLLSRAALtk-------- 150 Mucilaginibacter paludis...
WP_014021980                        97 IFGFE-DwKYINLYEVLIYPTFFN-----------EKFSL-D-AADRRVSGMVGNgp-mEGVMILSKKALel-------- 153 Cyclobacterium marinum...
WGS:AAXU:1101174000286_ALPR1_16838  98 IFRFP-EwEYKNLCEVLLYPDLFT-----------EKFDF-T-GDHRYTSGMVGSggpmNNVVIFSKPALrq-------- 155 Algoriphagus machipongonensis...
WP_011516845                       160 hgehelPVDT--YNVVIHEFAHKLDMLNGEADGVPPFsrvlhPGVDAEQWAETFLSEYDTFAEACdalpdhiwddpdrlp 237 Cupriavidus metallidurans...
WP_014782549                       150 ----gfENDMdkGNTGVHEFVHLIDKMDGVADGVPERl---lQRQYITPWLKLIHEEMETINSNK--------------- 207 Aequorivita sublithincola...
WP_013072779                       150 ----gfKNTTdkSNTGIHEFVHLIDKLDDRTDGVSERl---mEHQYAIPWLNLIHKEMEAINDNH--------------- 207 Flavobacteriaceae...
CDF79000                           151 ----gfSNAHdkSNTAIHEFVHLIDKMDGETDGVPEYi---mKHAYTIPWLKLIHKEIEAIHNNK--------------- 208 Formosa agariphila KMM 3901...
CCH01691                           159 ----gfMNKTskENTGIHEFVHLLDKVDGEIDGAPDLl---mPKEHLQPWLRLIHRTMQEMESHK--------------- 216 Fibrella aestuarina BUZ 2...
jgi:Sph21_3673                     155 ----gfSENSneSNTAIHEFVHLIDKRDGSVDGIPELl---lARPYVIPWIKMMHAEMHRIKAGR--------------- 212 Sphingobacterium sp. 21...
WP_012792193                       150 ----afSGSPgtEHTAIHEFVHLLDMSDGATDGIPENl---mRHEYTVPWLKMMHEEMRRIEQGR--------------- 207 Chitinophaga pinensis...
WP_008509629                       151 ----gfSDQAgkENAAIHEFVHLLDKSDGATDGVPENl---mPHEYAMPWLQMMHREMHRIEEGK--------------- 208 Mucilaginibacter paludis...
WP_014021980                       154 ----gfKNETdkKNTAIHEFIHLIDKTDGSVDGIPSLl---mERQYAIPWLDYINKKIEEIHEGK--------------- 211 Cyclobacterium marinum...
WGS:AAXU:1101174000286_ALPR1_16838 156 ----gfENRSdkFNVGIHEFVHLFDKQDGSIDGIPAIi---mKNQSVLPWLHLIKSNTSEILSGK--------------- 213 Algoriphagus machipongonensis...
WP_011516845                       238 prlQVIDPYGCEAPSEFFAVASEAFFVEPIGLRRQWPTLYDALTLFYR 285 Cupriavidus metallidurans
WP_014782549                       208 ---SDIRKYGGTNQTEFLAVASEYFFERPDLFKKKHPDLYQMLSKCFQ 252 Aequorivita sublithincola
WP_013072779                       208 ---SDIRKYGGTNQAEFFAVASEYFFERADLLKRKHPELYGMLVECFR 252 Flavobacteriaceae
CDF79000                           209 ---SDIRSYGGTNQAEFFAVASEYFFENPKLMKRKHPELFNMLQKSFQ 253 Formosa agariphila KMM 3901
CCH01691                           217 ---SDINPYGLTNEAEFFAVVSEYFFKRPDLLKTKHPELFAQLEQIFR 261 Fibrella aestuarina BUZ 2
jgi:Sph21_3673                     213 ---SDIDPYALTNEAEFLAVVSEYFFEKPTKFRDHHPELFDLLTKMFg 257 Sphingobacterium sp. 21
WP_012792193                       208 ---SDINPYALTNEAEFLAVASEYFFQKPERFKQHHPEMYAQMSRIFg 252 Chitinophaga pinensis
WP_008509629                       209 ---SDINPYALTNEAEFLAVASEYFFEKPQQFQTKHPEIYRQLSQIFg 253 Mucilaginibacter paludis
WP_014021980                       212 ---SDINPYGGTNQAEFFSVASEYFFERPKLLKRKHPKLYALLERVFn 256 Cyclobacterium marinum
WGS:AAXU:1101174000286_ALPR1_16838 214 ---SDINPYGATNNQEFLAVVSEYFFERPKLFQKKHPELYRILSQVFQ 258 Algoriphagus machipongone...
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