Conserved Protein Domain Family
GBBH-like_N

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pfam06155: GBBH-like_N 
Gamma-butyrobetaine hydroxylase-like, N-terminal
This domain is found in several proteins including gamma-butyrobetaine dioxygenase, Fe-S cluster assembly factor HCF101 and trimethyllysine dioxygenase proteins. Gamma-butyrobetaine hydroxylase (GBBH) is a alpha-ketoglutarate-dependent dioxygenase that catalyzes the biosynthesis of L-carnitine by hydroxylation of gamma-butyrobetaine (GBB). GBBH is a dimeric enzyme. The monomer consists of a catalytic double-stranded beta-helix domain and a smaller N-terminal domain. The N-terminal domain has a bound Zn ion, which is coordinated by three cysteines and one histidine. The N-terminal domain could facilitate dimer formation, but its precise function is not known. Other family members have been suggested to be involved in FeS cluster maintenance.
Statistics
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PSSM-Id: 488176
Aligned: 133 rows
Threshold Bit Score: 63.0298
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013579036  35 RVMKSEGTGVAIEWKDGHHSAWNFAWLRAGCPCATCN----EER---NASgrkpgevkpsaptgplvlyqAPP--RPVDV 105 Granulicella tu...
XP_002118481  40 vENRVQDKLVSVKWDDGKITDYPHVYLRDNCRCPSCFdpqaQQRiisNPIy------------------hNYAnaTVKTA 101
XP_006955803  29 pkvEYDDKQVKVNWESGRTSSFHNIWLRDHCRSPHSFhsitKQRlvnTSLi------------------pSNI--KPINI 88 
XP_011127889  91 hkiSFDDKKISVPWEEGKTSTFQHIWLRDHCQCSSCMhpqtKQRmldTFSl------------------pLNI--RPSQV 150
XP_001836221  71 pivSSDEKQVAVGWDTRTWSRFHNIWLRDHCRCPKCFhhitKQRlqsTFEi------------------pADI--APLRV 130
EGN99064      45 pitSADDRKVSVCWSPQKWSRFHNIWLRDHCRCPQCFhsvtKQRlvnTFEi------------------pPDI--KPVHV 104
ESK92365      79 pivSMDDRKVAIGWDTRTWSRFHHIWLRDHCRCPSCFhtvtKQRlvnTFEi------------------pPDI--QPLHV 138
CCE82706      11 TKLSEDGSQVLLTWDTGITSKYHNIWLRDNCRCEECYydvtKQRlfnSCLi------------------pDDI--KPVKL 70 
XP_007375535   6 tatnQGNDQLELTWSDGKTSKYHYIWLRDNCHCSTCYfpttKQKlasAATi------------------dDHI--APKNV 65 
XP_006688309   8 nelKPDGGELVVSWTDGQTSRFHNVWLRDNCHCDECYysitKQRllnSASi------------------dENIhvKSVTV 69 
WP_013579036 106 T-PVGKYAIRFKWNDG----HESGIYSWDYL 131 Granulicella tundricola
XP_002118481 102 CmNENKDKLHLEWINDg--eHTSSVFELDWL 130
XP_006955803  89 E--STPSGLSIKWNDGt--eQPSS-YPWKWL 114
XP_011127889 151 E--PKDEGLYVKWRGD----HESL-YSWEWL 174
XP_001836221 131 E--PKAEGLEVVWNSSd--nHTSL-YPWTWL 156
EGN99064     105 H--STAEGLEVIWPTAatelHSSL-YPWSWL 132
ESK92365     139 D--ARVEGLEVTWPSSt--pHVSL-YPWSWL 164
CCE82706      71 ArGPDQASITIVWSQKg---HESK-YTAEWL 97 
XP_007375535  66 T--VGNSDIDIVWNQEd---HLST-YDFHWL 90 
XP_006688309  70 DgSGPAATVHIVWDQNs---HSST-YPAAWL 96 
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