6CZ6


Conserved Protein Domain Family
Peptidase_M78

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pfam06114: Peptidase_M78 
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IrrE N-terminal-like domain
This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.
Statistics
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PSSM-Id: 399250
Aligned: 49 rows
Threshold Bit Score: 53.5776
Threshold Setting Gi: 81511195
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CZ6_B 142 RDRFGISVV-ID------------DNLPDTAKRRYHPD----------------------TKVLRVAHW-LXPGQRAFQI 185 Mycobacterium tubercu...
P39780  33 AKDLDIWVHfED------------MGSMMVKYDG--------------------------MYSIVLNQK-KSREEQWEDF 73  Bacillus subtilis sub...
P45899  33 AEALDIRLSfKP------------VTSFALKHSG--------------------------IYNICLDSR-KSRTEQWYDF 73  Bacillus subtilis sub...
Q8ZS26  49 AEHLAIPIVpLSefqnefpeevgyLTKKDTKSFSAVTVfd-------------------gTRRLIVHNDaHGLLRQASNV 109 Nostoc sp. PCC 7120
Q8YVK0  31 FERLPANTLaAK------------LGATVLTPDQFPNLpaeqvqrllasdewsgaivcdrPLIIVYNPL-HADTRYESNV 97  Nostoc sp. PCC 7120
Q8FQB1 162 VEYFGIRAYsLP------------ALAEKVDAFSVWSGr---------------------VPFVFIARR-KTPEQFRFDI 207 Corynebacterium effic...
Q9JXJ6 148 LEVKGVRVFsLS------------LDTKDIDAFCTWYEn---------------------HPFVFLNTQ-KSAERSRFDA 193 Neisseria meningitidi...
O53463 153 MEAAGCLVFeED------------FATQRIDGLSQWVDd---------------------YPVMLINAN-AAPDRKRLTL 198 Mycobacterium tubercu...
Q89E67 157 VEDAGILVAhSD------------LGGSSVSGVRFSVPg--------------------mPHIIVLNRS-HPADRMRFTL 203 Bradyrhizobium japonicum
Q9X8B2 172 LESRGIVVTvLP------------FPNADSRKLDGFSTsrl-----------------ptRPVVVLNDErDDVYRHRFSC 222 Streptomyces coelicolor
6CZ6_B 186 ATQLALVGQSDLISSI---VATDDQLSTEARGVARIGLanyfAGAFLLPYREFHRAAEQLRYDIDL---LGRRFGVGFET 259 Mycobacterium tubercu...
P39780  74 GHELCHVLKHAGN------HFQMNKLFRELQEFQANQF----MYHFCVPTFMLLQMELPQWRSQALa-tIAAVFRVTKEF 142 Bacillus subtilis sub...
P45899  74 AHEFCHIYRHEGDK------KTMPATWTDYLDWQSNYF----TYHFCIPTCMLRNINLPYIQSHAIe-nVAWLFKVSPSF 142 Bacillus subtilis sub...
Q8ZS26 110 SHELSHGILQHKPDKFl--NEYGCRNFNQEYENEANWL----GPALLISEEAALYIVKTGMTIDE----AVEYYRVSKEV 179 Nostoc sp. PCC 7120
Q8YVK0  98 MHEIAHVLLNHKRVGFd--PLTGLPKRQQINEDEATYL----GGCLQIPKRGL--LWATQRKMLLSe--IAVYFGASEAM 167 Nostoc sp. PCC 7120
Q8FQB1 208 AHELGHLTLHSNE------------PPAAKQEREADLF----AFELLLPRTAILERLPHNPSVEQLl-eLKNDYRVSAML 270 Corynebacterium effic...
Q9JXJ6 194 AHELGHLIRDKYSMEHsknSEITEDEPRDIIEKEANAF----ASAFLMPEAALRLYRHVPITIENLl-kIKRRFGVSLVA 268 Neisseria meningitidi...
O53463 199 AHELGHLVLHSTN-------------PTENMETEATAF----AAEFLMPESEIRPELRRLDLGKLLe--LKREWGVSMQA 259 Mycobacterium tubercu...
Q89E67 204 CHELGHVIMHSFP--------------TPEMEDEADRF----ASCFLVPTEDFKQSVAGRRVDLRTlaaLKPEWKVSMGS 265 Bradyrhizobium japonicum
Q9X8B2 223 AHELGHLLLHGEA-----------HPGDVQHERQADAF----AAEFLTPAARLTGSLPTRVDFTVLg-rLQQTWGVSLDS 286 Streptomyces coelicolor
6CZ6_B 260 VCHRLS 265 Mycobacterium tuberculosis H37Rv
P39780 143 ADKRLD 148 Bacillus subtilis subsp. subtilis str. 168
P45899 143 AKKRLS 148 Bacillus subtilis subsp. subtilis str. 168
Q8ZS26 180 INMRIN 185 Nostoc sp. PCC 7120
Q8YVK0 168 VQFRSN 173 Nostoc sp. PCC 7120
Q8FQB1 271 AAVATH 276 Corynebacterium efficiens
Q9JXJ6 269 LAYRMH 274 Neisseria meningitidis serogroup B
O53463 260 LLARAY 265 Mycobacterium tuberculosis
Q89E67 266 LVFAAE 271 Bradyrhizobium japonicum
Q9X8B2 287 LLVRCR 292 Streptomyces coelicolor
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