6GVW


Conserved Protein Domain Family
BRE

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pfam06113: BRE (This model is not part of the current CDD release)
Brain and reproductive organ-expressed protein (BRE)
This family consists of several eukaryotic brain and reproductive organ-expressed (BRE) proteins. BRE is a putative stress-modulating gene, found able to down-regulate TNF-alpha-induced-NF-kappaB activation upon over expression. A total of six isoforms are produced by alternative splicing predominantly at either end of the gene.Compared to normal cells, immortalised human cell lines uniformly express higher levels of BRE. Peripheral blood monocytes respond to LPS by down-regulating the expression of all the BRE isoforms.It is thought that the function of BRE and its isoforms is to regulate peroxisomal activities.
Statistics
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PSSM-Id: 517120
Aligned: 7 rows
Threshold Bit Score: 459.211
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6GVW_C        12 NRISPMLSPFISSVVRNGKVGLDATNcLRITDLKSGCTslt--pgPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFI 89  house mouse
XP_032511440  10 NEISPMFRPYIQSIYQDLKLGLCKAK-VDLERIGGNSS-------GAESQFRLVLPYCSKKLKWDVIFDTSTPWFAPDFR 81 
B6NXD5         9 KQLHPLIRPYAETVLRKGNVGVCMGN-LRISDVKSGRPtltqtkePCGDRFKIYIPFAGDSLKWEVIFDSCQPSNPPDFI 87  Florida lancelet
XP_011261127  10 STIDSYIEPLLKRVLQTKRLGVCCGL-IKLDSVSSSCNk------SKNDCFKLSIPYAGEHLVWSVLFDSQYPEMGPDFI 82 
XP_011151331  13 NTIDPYTEPLLKRVLHSKRLGISYGG-VKLNKGPTSCNk------SSNDCYKLTIPYAYENLLWTVLFDSQYPEIGPDFI 85 
XP_012062756  10 sTIDSYIEPLLKRVLQTKRLGVSYGP-IKLDSVSSSCNk------NKNDCFKLLIPYAGEHLMWNVLFNSQYPEMGPDFI 82 
XP_850681      8 NRISPMLSPFISSVVRNGKVGLDATNcLRITDLKSGCTslt--pgPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFI 85 
6GVW_C        90 F-GEDAEFLPDPSALH----NLASWNPSNPECLLLVVKELVQQYHQFQCGRL-RES-SRLMFEYQTLLEEPQYG-ENMEI 161 house mouse
XP_032511440  82 FdDDSFLSSANEDYLTksvpSLTNWDANNPKSLGDVLSELIKLYKIHQVRKLhEDAnSRASFEYSALMGNALTTeKDVEV 161
B6NXD5        88 FlGENGNFDPDIEKLE----NLTHWDPKNPESLVLAIEDLMREYRCYQKQLI--EGySRLQFEYSSLQGMEAC--DDVEV 159 Florida lancelet
XP_011261127  83 FnDQSFLADPDINTLStwipSLTKWNPNDIDALLNVLSELLLYYKEHQLHLLgKQG-DRLQFEYSTLVGETEISrEDIEV 161
XP_011151331  86 FnDQTFLMDPDIDILStkvpSLVKWDPTDSDALLNVLVELLLYYKEHQIESLaQQG-DRLQFEYSTLVGNTELHvDDIEV 164
XP_012062756  83 FnDQNFLMDPDIDILStwvpSLVKWNPNNTDALLNVLMELLLYYKEHQILLLgKQG-DRLQLEYSTLVGETEICkEDIEV 161
XP_850681     86 F-GEDAEFLPDPSALH----NLASWNPSNPECLLLVVKELVQQYHQYQCSRL-RES-SRLMFEYQTLLEEPQYG-ENMEI 157
6GVW_C       162 Y---AGKKnnwtgefSARFLLKLPVDFSNIPTYLLKDvneDPGEDVALLSVSFEDTeatqVYPKLYLSPRIEHALGgssA 238 house mouse
XP_032511440 162 W---VGGH-------IVEFLIKLKVDVLRLPELYNDGteqNPGIDTALLLVRYPNS----TNAELILSPFLTKVLG---K 224
B6NXD5       160 H---MGNRlpgtldsPVNFLIRLPIDLSPIPQYLVKD---DPGEDLAVLLAKFHNSegsrVTPQLFLSPKVEHALGdntA 233 Florida lancelet
XP_011261127 162 ImlpLGTKp-----tEARFLIRIVMDYSRLPPRINKS-----QNDEAMLIIMFYGPdwnrIIPQLYLSKTLEDIFGgpeS 231
XP_011151331 165 IllpLGGKp-----vEARFLIRISMDCC-LPPCVDKL-----HDNETMLHITFYGPdwnrIIPKLYLSKTLEKAFGgpdS 233
XP_012062756 162 Mv-lLGLKp-----mEARFLIRISMDYTRLPPRINKS-----QNDEAMLLVTFYGPdwnrISPQLYLSKTLEDAIGrpeS 230
XP_850681    158 Y---AGKKnnwtgefSARFLLKLPVDFSNIPTYLLKDvneDPGEDVALLSVSFEDTeatqVYPKLYLSPRIEHALGgssA 234
6GVW_C       239 LHIPAFPG-GGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGftkLTLLLMWKDFCFLVHID 317 house mouse
XP_032511440 225 ITLPMMHH-SGVLMDYVPLVTEILNNKIYHLLNNDKLKRDLLAQLIVKYEGAILEHDASS---AALLLQMNDFYWILQVD 300
B6NXD5       234 LRIPRFPT-GGCLMDYVPQVQDFLQKQIDHIVEGYQRRREYVAAFISRFGGSVLEYDAESftkLSLVLEWNEFFFVLHIE 312 Florida lancelet
XP_011261127 232 LHIPPFPS-SKYLMDYVPEVKKFIDEKIHNVVQSFESRKSFITVLIVSQRGSILEYDAIEfnwISMLLEHRDFHFLIHFH 310
XP_011151331 234 LHLPPFPPtTKYLMDYVPEVKKYIEEKINAVVECFEKRKDFLAALLMIQSCSLLEYDTKEfdyCTIMLEQLDFHVLVHFY 313
XP_012062756 231 LHIPPLPP-NKYLMDYVPEVIKFMEEKINSAIQCFENRKEFIVFLLVLQRGSIVEYDAIEfnwIIILLEHRDFHFLIHFN 309
XP_850681    235 LHIPAFPG-GGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGftkLTLLLMWKDFCFLVHID 313
6GVW_C       318 LPLFFPRDQPTLTFQSVYH 336 house mouse
XP_032511440 301 IGIKFPEKPPVLTLRSVYY 319
B6NXD5       313 LPSRFPQDMPVFTFQSCYH 331 Florida lancelet
XP_011261127 311 LPSTFPKEKPQITLQSVYH 329
XP_011151331 314 LPPGFPKESPQITLYSVYH 332
XP_012062756 310 LPSIFPKEKPQITLQSVYH 328
XP_850681    314 LPLFFPRDQPTLTFQSVYH 332
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