2H2N


Conserved Protein Domain Family
Apyrase

?
pfam06079: Apyrase (This model is not part of the current CDD release)
Apyrase
This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolyzing enzymes implicated in the inhibition of host platelet aggregation through the hydrolyzis of extracellular adenosine diphosphate..
Statistics
?
PSSM-Id: 517098
Aligned: 43 rows
Threshold Bit Score: 344.146
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2H2N_A        51 LDTESR--AQEENTWFSYLKKGYLTLSd-------SGDKVAVEWDKDh---gVLESHLAEKGRGMELSDLIVFNGKLYSV 118 human
XP_002140694  54 LDLKSRpsNPGEKDFRSILQKGRIYFDt-------KEEQYKVTWDAAl----VLLSGHNEYGRGMELSELVIYDGKLLAG 122
XP_002181909  11 LDELSRveWEKKPTFRSVLVPGTLTA---------TQGRYHIKFENAr----ELLTLHNEAGRGAEFSELTVYNDRLLTF 77 
XP_648646     36 LDKASK----EGQMWRSVVIVGII-----------FRQGNSYDFQEQee--fNISLPINENGRGMELSELLSFNGSLYGF 98 
XP_649057     50 LDSTKK-------QHICKVHFGML-----------FKEKDEWKFNESvskgfDVVSNYLYKTRGNEMSEIISFYDKLFVF 111
XP_002674693  69 LDKDSK--YKNDFKWRSFVIKGIVKRK--------ANGKYSIEFGKDns-kfEIQSLLARRNRSMELSTLSLWRGKFYAT 137
XP_002286296   8 LDKLSVvtDSKKPLFRSTLLPGTLTRDd-------KTNRYSIKFEQHr----TLVSQHNEAGRGMELSELTIYNNRLLSF 76 
XP_654244     67 LDKASK----LNKKWRSSMIIGTI-----------FKQGNTYEFQQQee--fNLTLGINENGRGMELSELLNFNGELYGF 129 Entamoeba histo...
XP_002895412 143 LDKKSKddNSKKPQFLSYIMHATLKVTpgsssathKRDAYSVTFGEEt----KFSTHMNEAGRGFELSELAWFDGKLLAF 218 Phytophthora in...
XP_627524     54 LDMNSKp-GNGEKNYKSLFQKGSIIQD--------KRGNYRVDWGEIl----ELKSGYNEYGRGMELSELISYNGMMLAG 120 Cryptosporidium...
2H2N_A       119 DDRTGVVYQI-EGSK--------AVPWVILSDGDGTVEKGFKAEWLAV-KDERLYVGGLGKEWTTTTGDVVNENPEWVKV 188 human
XP_002140694 123 DDRSGIMFEIiDDGKv-------IAPRYILSEGDGNKGKGMKIEWATV-RDDVLWVGSFGKEFVQ-NGIISKQDNMWVAS 193
XP_002181909  78 DDRTGDVFELlNNAEatk---sfVVPRFVITEGNGDTDKGMKWEWSTV-KNGELYMGSMGKEYTRPDGTIQNRNNLWIGI 153
XP_648646     99 DDRTGLVCAIdIEKKk-------AYPRLILRDGDSFSDKGMKIEWATV-YKDSMYVGSIGKEFTTPTGEYLNDNPLYVKQ 170
XP_649057    112 DDKTGIGHQLdIKNKk-------FYARVIMADGNGTSDSAFKPEWATI-VDDTLYLGSQGLDSLNVDGVIGRSNKYYIQK 183
XP_002674693 138 CDYTGIVYEIdMEQEr-------AYPRHVLYSGDGNTKIPLKAEWSTVgPDDRLYIGSIGKEWV-ANGEALNRHCEWVKV 209
XP_002286296  77 DDRTGTVFEIlSTPDgsd---syVVPRFVITEGDGDTDKGMKWEWATV-KNNELVLGSMGKEFTRPDGSIENTNNLWVAM 152
XP_654244    130 DDRTGVVMAIdLEKKk-------TYPRYILMDGDLNSDKGMKIEWATV-YKDSMYIGSIGKEFTTPTGEYLNDNPLYIKK 201 Entamoeba histo...
XP_002895412 219 DDRTGIVFRLkHFEGisrtkplqAIPEHIIMEGDGFNGKGQKHEWATV-KDGELYMGSVGKEFTDNDGNVIGDGNLWVAV 297 Phytophthora in...
XP_627524    121 DDRTGIIFEItDDGKg-------VAPRYILSEGNGRTAKGMKIEWFAV-RDGILWVGSFGKEFVS-NGIIEKRDNMWVAT 191 Cryptosporidium...
2H2N_A       189 V-GYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQE-RYSEKDDERKGA-NLLLSASPDF 265 human
XP_002140694 194 V-DKFGNIRYYNWSKVYNSIRSALDADFPGYCIHEAVGWSPYMRKWIFLPRRVSNE-PYDEFLDEMKGS-NKMVILSDDL 270
XP_002181909 154 L-NAEGELRREDWTDQYNVVRKALKALSPGYLIIEAVNWSDHLQKWVFLPRRISET-AYDENEDERRGG-RQLVLVSPDF 230
XP_648646    171 I-NVDGKVSVLNWKNKFNAIKNAVRIYGEGYMIHEAVAYSVSDNKWYFAPRKCSNE-RYDDIKDEVRGC-PYIIS-TKDF 246
XP_649057    184 V-KKNGVYETVDFSFVYKTIDNLLGVSSPGYTSMEAVVFSNVNRKWYFAPRKISNI-AYNETYDNLYASgKYVVEFDENF 261
XP_002674693 210 IdRKSYKEISVDWGEVYMRLRQSVNATEPGYLIHESVFYDKFLKEWIFLPRRHSEDvKYNEKSDEYLGA-NIMIRTDIDL 288
XP_002286296 153 L-NDRGELRREDWEDKFNFVRKLVGAAPPGYIIMEAILWSDKLKRWVFLPRRISST-AYDEVADEKMGA-TKVVLVNESF 229
XP_654244    202 I-DQNGKITAINWKNKYNNLKNAVGIYGDGYMINEAVTYSASANKWYFAPRKCSKE-KYDDSKDETRGC-PYIIS-TEDF 277 Entamoeba histo...
XP_002895412 298 M-NRAGEVRHEDWTANFAAVRKALGCEWPGYVVHEAIEWSPVRRQWFILPRRVSTE-PYNDMEDERRGS-NKIIIASEDF 374 Phytophthora in...
XP_627524    192 I-DKRGHVSRFNWSFVYEKIRNSLGAQYPGYCIHEAVIWSHLMRKWIFLPRRVSFD-EYDEEKDEKRGS-NKMIIMTDDF 268 Cryptosporidium...
2H2N_A       266 -GDIAVSHV--GAVV--PTHGFSSF-----------KFIPNTDDQIIVALKSEED------SGR-VASYIMAFTL-DGRF 321 human
XP_002140694 271 -EILDVKAI--GDII--PERGFSSF-----------KFLPGSKDQIIVALKTVENs-----RIDfQSTYVSMFTI-DGDL 328
XP_002181909 231 -SSTQVVDI--NLQKd-PLKGFSTF-----------AFVPNTNDRHAFAIRSVEEdcvgglETCkQRSYFIVFDVlSGET 295
XP_648646    247 -IHFNIINDpqHDFN----KGFSSI-----------KILPHDEN-KLIYLKSVEV------GKR-SETYMGMIST-TGEV 301
XP_649057    262 -QNPRVFTD--SQFN--KSHGFSSI-----------KLIPYQED-VILYLKTFEN------EDK-LETFIGMMNL-EGKS 316
XP_002674693 289 qQVKKVVRV--GRKSenPEEFYDNFldkrfgftdivRLTKTAGNNHYLATRVIEVs----hPEEiVETYLTIFDD-NGVV 361
XP_002286296 230 -TDGTVVDI--NMKTvdPLHGFSTF-----------AFVPGTNDHHALAVRSVEEdctgelELCkQRSYLMVFDIlTGEV 295
XP_654244    278 -TNFDIINDpqHDLN----KGFSSI-----------KVLPNDEN-KLVYLKSVEV------GER-SETYIGMIST-SGEV 332 Entamoeba histo...
XP_002895412 375 -SSIQVREV--GKVT--PLRGFSSF-----------KFVPRSDDSVIVAIKSVEVe-----DEErQTSYITVFSV-DGNV 432 Phytophthora in...
XP_627524    269 -EILEIIDV--GLII--PERGFSSL-----------KFLPGSFDQIIVATKSVEEs-----ISDtQKSFLTIFTI-NGKI 326 Cryptosporidium...
2H2N_A       322 LLPE--------TKI-GSVKYEGIEFI 339 human
XP_002140694 329 LIDD--------IKVpGEFKFEGIEFT 347
XP_002181909 296 LSEE--------VKYpEDLKFEGLEFV 314
XP_648646    302 IMKE--------KLI-TKMKMEGIEFI 319
XP_649057    317 LMKE--------KSL-GANKFEGIEII 334
XP_002674693 362 LLDSptgvlelpEELgKGEKYEGIEVF 388
XP_002286296 296 LMDE--------VQIdLAEKFEGIEFV 314
XP_654244    333 LMQD--------KLV-AKMKMEGIEFI 350 Entamoeba histolytica HM-1:IMSS
XP_002895412 433 LMEE--------TEIpGAKKYEGVAFA 451 Phytophthora infestans T30-4
XP_627524    327 LMED--------LEVpGDYKYEGIEFI 345 Cryptosporidium parvum Iowa II
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap