2H2N


Conserved Protein Domain Family
Apyrase

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pfam06079: Apyrase 
Apyrase
This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate..
Statistics
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PSSM-Id: 399223
Aligned: 47 rows
Threshold Bit Score: 337.586
Threshold Setting Gi: 284088285
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H2N_A                    52 DTESRa--QEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHg---VLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVY 126
EFC41949                  70 DKDSKy--KNDFKWRSFVIKGIVKRK-ANGKYSIEFGKDNsk-fEIQSLLARRNRSMELSTLSLWRGKFYATCDYTGIVY 145 Nae...
XP_648646                 37 DKASK----EGQMWRSVVIVGII----FRQGNSYDFQEQEe--fNISLPINENGRGMELSELLSFNGSLYGFDDRTGLVC 106 Ent...
XP_654244                 68 DKASK----LNKKWRSSMIIGTI----FKQGNTYEFQQQEe--fNLTLGINENGRGMELSELLNFNGELYGFDDRTGVVM 137 Ent...
WGS:AAFB:cds.EHI_103690A  51 DSTKK-------QHICKVHFGML----FKEKDEWKFNESVskgfDVVSNYLYKTRGNEMSEIISFYDKLFVFDDKTGIGH 119 Ent...
XP_002181909              12 DELSRvewEKKPTFRSVLVPGTLTA--TQGRYHIKFENAR----ELLTLHNEAGRGAEFSELTVYNDRLLTFDDRTGDVF 85  Pha...
CBJ27122                  90 DKKSKv-dDKGKQYRSVLQAAALTRDPATKKFSVEMGEAT----DLFSGHNEAGRGMELSELINYRGSLLTVDDRTGIVF 164 Ect...
EAK89829                  55 DMNSKp-gNGEKNYKSLFQKGSIIQD-KRGNYRVDWGEIL----ELKSGYNEYGRGMELSELISYNGMMLAGDDRTGIIF 128 Cry...
XP_002140694              55 DLKSRpsnPGEKDFRSILQKGRIYFDTKEEQYKVTWDAAL----VLLSGHNEYGRGMELSELVIYDGKLLAGDDRSGIMF 130 Cry...
EED95937                   9 DKLSVvtdSKKPLFRSTLLPGTLTRDDKTNRYSIKFEQHR----TLVSQHNEAGRGMELSELTIYNNRLLSFDDRTGTVF 84  Tha...
2H2N_A                   127 QI-EGSk-----AVPWVILSDGDGTVEKGFKAEWLAV-KDERLYVGGLGKEWTTTTGDVVNENPEWVKVV-GYKGSVDHE 198
EFC41949                 146 EIdMEQe----rAYPRHVLYSGDGNTKIPLKAEWSTVgPDDRLYIGSIGKEWV-ANGEALNRHCEWVKVIdRKSYKEISV 220 Nae...
XP_648646                107 AIdIEKk----kAYPRLILRDGDSFSDKGMKIEWATV-YKDSMYVGSIGKEFTTPTGEYLNDNPLYVKQI-NVDGKVSVL 180 Ent...
XP_654244                138 AIdLEKk----kTYPRYILMDGDLNSDKGMKIEWATV-YKDSMYIGSIGKEFTTPTGEYLNDNPLYIKKI-DQNGKITAI 211 Ent...
WGS:AAFB:cds.EHI_103690A 120 QLdIKNk----kFYARVIMADGNGTSDSAFKPEWATI-VDDTLYLGSQGLDSLNVDGVIGRSNKYYIQKV-KKNGVYETV 193 Ent...
XP_002181909              86 ELlNNAeatksfVVPRFVITEGNGDTDKGMKWEWSTV-KNGELYMGSMGKEYTRPDGTIQNRNNLWIGIL-NAEGELRRE 163 Pha...
CBJ27122                 165 EIlEEQge--rhMAPRYILPEGDGNLDKGMKLEWATE-KDGSLVVGSFGKEYTDNDGRIVNTNNNWIITI-DPHGVISRQ 240 Ect...
EAK89829                 129 EItDDGk----gVAPRYILSEGNGRTAKGMKIEWFAV-RDGILWVGSFGKEFVS-NGIIEKRDNMWVATI-DKRGHVSRF 201 Cry...
XP_002140694             131 EIiDDGk----vIAPRYILSEGDGNKGKGMKIEWATV-RDDVLWVGSFGKEFVQ-NGIISKQDNMWVASV-DKFGNIRYY 203 Cry...
EED95937                  85 EIlSTPdgsdsyVVPRFVITEGDGDTDKGMKWEWATV-KNNELVLGSMGKEFTRPDGSIENTNNLWVAML-NDRGELRRE 162 Tha...
2H2N_A                   199 NWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQE-RYSEKDDERKGA-NLLLSASPDF-GDIAVSHV-- 273
EFC41949                 221 DWGEVYMRLRQSVNATEPGYLIHESVFYDKFLKEWIFLPRRHSEDvKYNEKSDEYLGA-NIMIRTDIDLqQVKKVVRV-- 297 Nae...
XP_648646                181 NWKNKFNAIKNAVRIYGEGYMIHEAVAYSVSDNKWYFAPRKCSNE-RYDDIKDEVRGC-PYIIS-TKDF-IHFNIINDpq 256 Ent...
XP_654244                212 NWKNKYNNLKNAVGIYGDGYMINEAVTYSASANKWYFAPRKCSKE-KYDDSKDETRGC-PYIIS-TEDF-TNFDIINDpq 287 Ent...
WGS:AAFB:cds.EHI_103690A 194 DFSFVYKTIDNLLGVSSPGYTSMEAVVFSNVNRKWYFAPRKISNI-AYNETYDNLYASgKYVVEFDENF-QNPRVFTD-- 269 Ent...
XP_002181909             164 DWTDQYNVVRKALKALSPGYLIIEAVNWSDHLQKWVFLPRRISET-AYDENEDERRGG-RQLVLVSPDF-SSTQVVDI-- 238 Pha...
CBJ27122                 241 DWTKQYNTLRDKVGATFPGYMIHESAAWSDALNKWVFLPRRISSE-KYDDVRDEKMGS-NTILIVDEDF-RKVDVRHV-- 315 Ect...
EAK89829                 202 NWSFVYEKIRNSLGAQYPGYCIHEAVIWSHLMRKWIFLPRRVSFD-EYDEEKDEKRGS-NKMIIMTDDF-EILEIIDV-- 276 Cry...
XP_002140694             204 NWSKVYNSIRSALDADFPGYCIHEAVGWSPYMRKWIFLPRRVSNE-PYDEFLDEMKGS-NKMVILSDDL-EILDVKAI-- 278 Cry...
EED95937                 163 DWEDKFNFVRKLVGAAPPGYIIMEAILWSDKLKRWVFLPRRISST-AYDEVADEKMGA-TKVVLVNESF-TDGTVVDI-- 237 Tha...
2H2N_A                   274 GAVV--PTHGFSSF-----------KFIPNTDDQIIVALKSEED------SGR-VASYIMAFTL-DGRFLLPE------- 325
EFC41949                 298 GRKSenPEEFYDNFldkrfgftdivRLTKTAGNNHYLATRVIEVs----hPEEiVETYLTIFDD-NGVVLLDSptgvlel 372 Nae...
XP_648646                257 HDFN----KGFSSI-----------KILPHDEN-KLIYLKSVEV------GKR-SETYMGMIST-TGEVIMKE------- 305 Ent...
XP_654244                288 HDLN----KGFSSI-----------KVLPNDEN-KLVYLKSVEV------GER-SETYIGMIST-SGEVLMQD------- 336 Ent...
WGS:AAFB:cds.EHI_103690A 270 SQFN--KSHGFSSI-----------KLIPYQED-VILYLKTFEN------EDK-LETFIGMMNL-EGKSLMKE------- 320 Ent...
XP_002181909             239 NLQKd-PLKGFSTF-----------AFVPNTNDRHAFAIRSVEEdcvgglETCkQRSYFIVFDVlSGETLSEE------- 299 Pha...
CBJ27122                 316 GDIV--ETHGFSSF-----------KFVPGTGDQVVVALKSEEIe-----ELQtQTTFVMVFTL-DGEVLLEE------- 369 Ect...
EAK89829                 277 GLII--PERGFSSL-----------KFLPGSFDQIIVATKSVEEs-----ISDtQKSFLTIFTI-NGKILMED------- 330 Cry...
XP_002140694             279 GDII--PERGFSSF-----------KFLPGSKDQIIVALKTVENs-----RIDfQSTYVSMFTI-DGDLLIDD------- 332 Cry...
EED95937                 238 NMKTvdPLHGFSTF-----------AFVPGTNDHHALAVRSVEEdctgelELCkQRSYLMVFDIlTGEVLMDE------- 299 Tha...
2H2N_A                   326 -TKI-GSVKYEGIEFI 339
EFC41949                 373 pEELgKGEKYEGIEVf 388 Naegleria gruberi
XP_648646                306 -KLI-TKMKMEGIEFI 319 Entamoeba histolytica HM-1:IMSS
XP_654244                337 -KLV-AKMKMEGIEFI 350 Entamoeba histolytica HM-1:IMSS
WGS:AAFB:cds.EHI_103690A 321 -KSL-GANKFEGIEII 334 Entamoeba histolytica HM-1:IMSS
XP_002181909             300 -VKYpEDLKFEGLEFV 314 Phaeodactylum tricornutum CCAP 1055/1
CBJ27122                 370 -NEIpGGFKFEGLEIf 384 Ectocarpus siliculosus
EAK89829                 331 -LEVpGDYKYEGIEFI 345 Cryptosporidium parvum Iowa II
XP_002140694             333 -IKVpGEFKFEGIEFt 347 Cryptosporidium muris RN66
EED95937                 300 -VQIdLAEKFEGIEFV 314 Thalassiosira pseudonana CCMP1335
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