6ENO,3O3N


Conserved Protein Domain Family
HGD-D

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pfam06050: HGD-D (This model is not part of the current CDD release)
2-hydroxyglutaryl-CoA dehydratase, D-component
Degradation of glutamate via the hydroxyglutarate pathway involves the syn-elimination of water from 2-hydroxyglutaryl-CoA. This anaerobic process is catalyzed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) that reversibly associate during reaction cycles. This component contains one non-reducible [4Fe-4S]2+ cluster and a reduced riboflavin 5'-monophosphate.
Statistics
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PSSM-Id: 517088
Aligned: 293 rows
Threshold Bit Score: 37.6511
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ENO_A          77 VYVPEEIINATGsaciglCGGAQYTVPAGEtvLPRNLCPLikSAMGfkiericpyfqvadyvvgettCDGKKKAWEILNE 156  Carboxydothe...
22_pfamImport    2 WMYHSRLYRAAN------FVKTQDNLDLIQ--LNSFGCGL--DAVT---------------------TDQVNDILTKSGK 50  
CDE52912       417 WMYHSRLYRAAN------YVKTRDDLDLIQ--LNSFGCGL--DAVT---------------------CDCVNDILTNSGK 465 
21_pfamImport    2 WMYHSRLYAAAN------FVKTQENLDLIQ--LNSFGCGL--DAVT---------------------TDQVNDILTHSGK 50  
WP_013978066   909 WMYHSRLYAAAN------YVKTTDNLDLIQ--LNSFGCGL--DAIT---------------------TDMVSDILTQSGK 957  Clostridium ...
CDC13766       444 WMYHSRLYAAAN------FVKTQDNLDLIQ--LNSFGCGL--DAVT---------------------TDCVNDILSKSGK 492 
36_pfamImport    2 WMYHSRLYAAAS------FVKTRDDIDLIQ--LNSFGCGL--DAVT---------------------TDQVNDILSGSGK 50  
23_pfamImport    2 WMYHSRLYAAAS------YVRTVDNLDLIQ--LNSFGCGL--DAVT---------------------TDQVNDILTGSDK 50  
WP_013280861   907 WMYHSRLYAAAS------FVRTRDDIDLIQ--LNSFGCGL--DAVT---------------------TDQVNDILSGSDK 955  Butyrivibrio...
26_pfamImport    2 WMYHSRLYAAAS------YVKTRDDLDLIQ--LNSFGCGL--DAVT---------------------TDQVNDILSGSDK 50  
6ENO_A         157 YipVYVMELpqkkeerdrkfweEEIKDFAQFveektgvKLNAENLRAGIEKINK-----------------KRKALKRLS 219  Carboxydothe...
22_pfamImport   51 I--YTVLKI-------------DEVNNLGAA-------RIRIRSLLSAIRVREKlnekrtivpaninrvefTKEMKEN-Y 107 
CDE52912       466 I--YTVLKI-------------DEVNNLGAA-------RIRIRSLISALRVRKEnhiqrkirpanvekqefTKEMRDEGY 523 
21_pfamImport   51 I--YTCLKI-------------DEVNNLGAA-------RIRIRSLISAIRVRERkhyqhdvvtsaysrvffTKEMKKD-Y 107 
WP_013978066   958 I--YTCLKI-------------DEVNNLGAA-------RIRIRSLIAAIRTREKhptkrdlvptnhnrvlfTEEMRAEGY 1015 Clostridium ...
CDC13766       493 I--YTCLKI-------------DEVNNLGAA-------RIRIRSLLAAIRVKEKrqekrtivpanfnrvvfTEEMRDS-Y 549 
36_pfamImport   51 I--YTCLKI-------------DEVNNLGAA-------RIRIRSLLSAIRVREQrhqtrtihssqmhrilfTKEMRKN-Y 107 
23_pfamImport   51 I--YTCLKI-------------DEVNNLGAA-------RIRIRSLIAALRVKEQkheervvhstainrpvfTEEMRKE-Y 107 
WP_013280861   956 I--YTCLKI-------------DEVNNLGSA-------RIRVRSLLAAIRVRKQknkqrtiretanhrvlfTEDMRKN-Y 1012 Butyrivibrio...
26_pfamImport   51 I--YTCLKI-------------DEVNNLGAA-------RIRIRSLLSALKVREKqnkkrtlhssaivkvpfTEEMRKN-Y 107 
6ENO_A         220 DLR-KH-NpaPIHGldvllinqlaffddperfatkvNeLCDELEErvakgegvvskdaprilITGTPQPIPHWKI----- 292  Carboxydothe...
22_pfamImport  108 TILcPQmS--PIHF----------------------E-LVETAFK-----------------TCGYNIVVLQNDN----- 140 
CDE52912       524 TILvPQmT--PIHF----------------------D-LLGPALK-----------------ACGLNIVMLQSDTdspdy 561 
21_pfamImport  108 TILcPQmS--PIHF----------------------D-LIEPAVR-----------------SCGYKLEVLQNSD----- 140 
WP_013978066  1016 TIIaPQlS--PIHF----------------------D-ILGPAFR-----------------SCGYNVVVLDNDT----- 1048 Clostridium ...
CDC13766       550 TILcPQmS--PIHF----------------------E-LLEPAFQ-----------------AAGYHLVVLDNDN----- 582 
36_pfamImport  108 TILcPQmS--PIHF----------------------D-LLEPTFR-----------------RCGYNLVVLNNDN----- 140 
23_pfamImport  108 TILcPQmS--PFHF----------------------D-LMEAAFR-----------------AAGYNLEVLPTDN----- 140 
WP_013280861  1013 TLLcPQmS--PIHF----------------------D-ILEPAFA-----------------ACGYNFVVMQNDN----- 1045 Butyrivibrio...
26_pfamImport  108 TIIcPQmS--PIHF----------------------E-LLQPAFN-----------------ACGYNFVVLDNDN----- 140 
6ENO_A         293 ----HALIEGA-GgvVVGEETcigERYFkdlvepaadvEg-mLKNIAaRSLkvncacftpntgrledilsmvQKLQVDGV 366  Carboxydothe...
22_pfamImport  141 ----RTAVDTGlK--FVNNDAcypSLIV----------VgqiMDALLsGKY---------------------DLNKTAVV 183 
CDE52912       562 kekcRNAVDIGlK--YVNNDAcypSLIV----------VgmmMDAVLsGKY---------------------DVNKLAII 608 
21_pfamImport  141 ----RTAIDTGlK--FVNNDAcypSLIV----------VgqiMSALLsGKY---------------------DLNRTAII 183 
WP_013978066  1049 ----KEAVDTGlK--YVNNDAcypSLIV----------VgqmLAAVEsGKY---------------------DTDRLAII 1091 Clostridium ...
CDC13766       583 ----RDSVDVGlK--YVNNDAcypSLMV----------VgqiMSAVMsGKY---------------------DMTKTAIL 625 
36_pfamImport  141 ----KHSVDMGlK--YVNNDAcypSLLV----------VgqiMDAVLsGQY---------------------DTDHLAVV 183 
23_pfamImport  141 ----RHAVDTGlK--YVNNDAcypSLIV----------VgqiMDALLsGKY---------------------DTNKVAVV 183 
WP_013280861  1046 ----RHAIDMGlK--YVNNDAcypSLWV----------VgqiMDELHsGKY---------------------DLNRTAVI 1088 Butyrivibrio...
26_pfamImport  141 ----KHSVDVGlK--YVNNDAcypSLLV----------VgqiMQALLsGKY---------------------DLDRTAII 183 
6ENO_A         367 IHYSLQFCQpYGVESYLVGRELeRRN----IPFLKLES------------------------------------------ 400  Carboxydothe...
22_pfamImport  184 MSQTGGGCR-ASNYVGFIRRAL-EKAgmaqIPVVSISAqglehnegfkitpkllfkalqavvygdifmrvlyrmrpyei- 260 
CDE52912       609 MTQTGGGCR-ASNYVGFIRRAL-QKAgypqIPVISLSVqglesnsgfqytpemvvkgvqaliygdvfmrclyrmrpyei- 685 
21_pfamImport  184 MSQTGGGCR-ASNYIGFIRRAL-ERAgmpqIPVISLNAngmetnpgfsftlpmvikalqavvygdvfmrvlyatrpyea- 260 
WP_013978066  1092 MTQTGGGCR-ASNYVGFIRRAL-KKAgypqIPVISLNLsdleknpgfsftlpmaqkavygcvfgdilmrvinatrpyeav 1169 Clostridium ...
CDC13766       626 ISQTGGGCR-ASNYIGFIRRAL-EKAgykdVPVISINLsgleknpgfkftpqliqhglyalefgdifmrclyrtrpyeev 703 
36_pfamImport  184 MSQTGGGCR-ATNYIGFIRRAL-AKAgyshIPVISINLsklesnpgfkltpmlllravyavtfgdifmrcvyrmrpyea- 260 
23_pfamImport  184 MSQTGGGCR-ATNYVGFIRRAL-GKAglshVPVISINMsnslesnpgfklnadlltraaysavfgdifmrcvyrmrpyel 261 
WP_013280861  1089 MSQTGGGCR-ATNYVGFIRRAL-KKAgmeqIPVVSLNLsklesnpgfhinfemleraaygavfgdifmrcvyrmrpyek- 1165 Butyrivibrio...
26_pfamImport  184 MSQTGGGCR-ATNYIGFIRRAL-KKAgmeqIPVISLNLggiesnpgfhlnaelllraayaatfgdifmrcvyrmrpyeq- 260 
6ENO_A         401 ------------------------------------------DFSEEDQGQLKTRIEAFLEM 420  Carboxydothermus hydrogenoform...
22_pfamImport  261 -epcsanelhrkwrdkcnadlakpginnstfkknikgiikdfDNLPIHEDIVKPRVGVVGEI 321 
CDE52912       686 -nagsadelhekwkttcirqlekpgfhmgefrknltaiieefDRLPIHEDMKKPRVGIVGEI 746 
21_pfamImport  261 -kpgsadalheqwkerciasltkkkpsmkefsrnlrgiisdfDTLA-RRNVVKPKVGIVGEI 320 
WP_013978066  1170 pgttdkmhqkwlrrinkflcqdkkwlshrtykrfcremvrdfDHIE-RKNIEKPKVGIVGEI 1230 Clostridium sp. SY8519
CDC13766       704 -pgsanalhekwkerviafisrkgfvshrkykkmcreiirdfDRLP-MKDIKKPKVGVVGEI 763 
36_pfamImport  261 -vpgsvnevhqkwikkcceflgrkympfstfkkmcvemieefDAIP-TLDIKKPRVGVVGEI 320 
23_pfamImport  262 -trgsvdavhekwklkcqefvsgkhmsffkfqrmcrqmieefDAIPVSEDP-KPRVGIVGEI 321 
WP_013280861  1166 -vegsvnachekwlpvvkefvtskhmsfikfqrlcrqiiedfDRIEITDEV-KPRVGVVGEI 1225 Butyrivibrio proteoclasticus
26_pfamImport  261 -ekgsvdavhakwlkvtqdfvtakhmsffkfnklcraiirdfDAIPIKEDLRKPRVGIVGEI 321 
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