Conserved Protein Domain Family
DUF927

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pfam06048: DUF927 
Domain of unknown function (DUF927)
Family of bacterial proteins of unknown function. The C-terminal half of this family contains a P-loop motif. The N-terminal domain appears to have a unique fold, which contains three Helices and two strands. Structural analyses show that helicases containing this domain form a hexameric ring with a positively charged central pore threading a single DNA strand through suggestive of a replicative function for this helicase.
Statistics
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PSSM-Id: 399206
Aligned: 19 rows
Threshold Bit Score: 274.583
Threshold Setting Gi: 74531901
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q01TT1        148 FSLD-----VDGTYECKVRRDLLGGTAidtvLVAHAPLLISGRLEDI--E---TGTQALQIH-WRRPDGWH-ERTVDRAV 215  Candidatus So...
jgi:M446_0810 363 YAMN-----SGGLTVEVIKGRGEARTEe--tIWCAAPFEVIGRARDP--Q---GQGWARWLR-WRDPDGRR-HEYAVPDA 428  Methylobacter...
jgi:Clos_1294 366 FRVS-----ENGIEMINYKTGIPQ-------LICRTPILISNRLKSL--D---SYDEKIEITfYRD------KKWHRVTE 422  Alkaliphilus ...
Q8TPL3          9 YEKN-----------------EEGKTEekpiVLAQRPVYITSKFKNFdkNvtlKEKEFLGIE-IHSKNGKIeELVVTPED 70   Methanosarcin...
Q8TNP8        114 FNLYpfrvsKNGIEVLNNNKDIEDYD-----VISETPIVISATGVNL--D---DETFLYQCT-YRNVIGDYnTKWVLPSD 182  Methanosarcin...
Q5HK55         13 rykS-----KKGWYKDKPPKEKGGMPTe---VEIAGPIVIENKFIDP--K---TNTEKVIIT-----DEDQ-KEIVESSD 73   Staphylococcu...
Q5HK67         11 FKLK-----PSGWYKTIPPKKDGGTEFe---IMLSGPIAFTDRFIDP--A---TRKEKVFLS-----DLNN-IELVEKAS 71   Staphylococcu...
Q8ZMQ9        130 FRLD-----EEALWFDKLTERRDGESDvq-pQRICSPLRVTAITCDS--H---DGSYGRLLE-WHTTTGQL-RRWAMPMA 196  Salmonella en...
Q7MPU9         31 FAYN-----AQNWLVMQPAGQDSP-------VKICSWLQVAARTRDP--Q---GDNYGYLLH-WLDDDNRH-RYWAMPAE 91   Vibrio vulnif...
Q4K6S5        413 FRLT-----PEGVFYAGDDGEARP---------VCSPLEIIARTRDE--K---GHNWGLLVE-FDDPDGAK-KRWNIPAR 471  Pseudomonas p...
Q01TT1        216 AL----DSRRIIELAGEGFPvFSNNA-----AGLTKYLEAVeaanySRLPRAHVSSHLGWQgrngEHGFLAGRSLI--Sg 284  Candidatus So...
jgi:M446_0810 429 ALhg-dAGALAAELASRGLT-VSRNGr----GHLCDYLNQV-----RVSARVTVVPRTGWHvvgdQQVFVLPDQVL--Gq 495  Methylobacter...
jgi:Clos_1294 423 QRsvifQARTIIKLADVGVTvTSENA-----KFLVKFLEKLeaenfDMIQTLQSVDQLGWH----NDNFLPGREGElvid 493  Alkaliphilus ...
Q8TPL3         71 IFt--kGKKGLGGLYNKKLLhFEDKE-----KDLAKFFVSFydlneDILKESVFADKNGWNa--dFTQFVFGNRVY--Fe 139  Methanosarcin...
Q8TNP8        183 ILss-----dIKKLANLGLHiNSNDS-----KYLLTYFKKMvk-yvRWMPKEYTALRTGWKk--dCAIFIIGNNSY--Sa 247  Methanosarcin...
Q5HK55         74 IL----TTQKLPSLMKYGFSiNEKYT-----KDLGYALQQMr----NQLPISYLYEGVGILet-pFGPIVSLSEIY--Tt 137  Staphylococcu...
Q5HK67         72 IL----TALQLPSLIEYGFTiNEKHI-----RDLGFVLQQMr----STTPLSTIYSGVGMLht-lLGPLISLDQPY--Fs 135  Staphylococcu...
Q8ZMQ9        197 MLsg-nGEELRRILLENGLTnISTRPal--rSLLCEYISRS-----LPGRRVTCVEKTGWH----NGVYVLPDEVI--Gp 262  Salmonella en...
Q7MPU9         92 LLag-dGSEYRRILLSRGMR-LSNSVka--rQLLSLFIQQMg---eLATQKAISVNCIGWH----HHAYVHPRLTFypSe 160  Vibrio vulnif...
Q4K6S5        472 TMtgdfGKDVLGPLVDMGLRlAGSRSgrnarNDLQSYLGGF-----DSAQRARLVTRLGWH----GNAFLLPEQQI--Gs 540  Pseudomonas p...
Q01TT1        285 sgeviqtqqkldmnsgvippgavafrgltpgdeqivDGWHARGSHDEWCR-AAHLVRDRPRVMAGL---YGALVPPLL-- 358  Candidatus So...
jgi:M446_0810 496 ptnetvv-----------------------lvgaaaaPYSARGTLDGWRRgVGQLSAGHGRLVLAI---ATALAGSLV-- 547  Methylobacter...
jgi:Clos_1294 494 vdt---------------------------nerkwiNAYRKIGTLDSWIKyMKDF-RHNTIFRFIL---ASSFAAPLL-- 540  Alkaliphilus ...
Q8TPL3        140 ggfkdihi-------------------pekfkndvtKGISSKGDIKEFERlTQKLFNTKAYRHLSY----IAILSLVL-- 194  Methanosarcin...
Q8TNP8        248 dgkrdii----------------------pidevmgEMYTQKGNRDEWIKiIAPMLDYDITRIKCY----SVVAAMIL-- 299  Methanosarcin...
Q5HK55        138 kefdnksps--------------------daicdnaydLTPKGTFDNWFNmYLKEVKGSLLLELAVvfgISALVTSFLkh 197  Staphylococcu...
Q5HK67        136 neitnsts----------------------iicdnkydLIPKGNLSEWLQmYKEEVHGNLSLELDVlfgVSSLVTAFLky 193  Staphylococcu...
Q8ZMQ9        263 dgdnvil----------------------qgshyltGGFAQAGTLAEWQEqVAALCAGNSRLVFAV---CCALAAPLL-- 315  Salmonella en...
Q7MPU9        161 hnnprmv----------------------lqtmhpiEGFIQQGSSDSWRQhVGCYCLDNPLLIVGV---CAALAAPLL-- 213  Vibrio vulnif...
Q4K6S5        541 heehlhf----------------------yeagaqlPPISEAGSLEQWQQqIGALCVGNHRLAFVV---SVAFAGPLL-- 593  Pseudomonas p...
Q01TT1        359 -AILRCPNFIMDWAHRTSVGKTTTLRLAASVWGNPNedavdTILRSWDSTQVYIERAASIISGLPLILDETKRVKDPGl- 436  Candidatus So...
jgi:M446_0810 548 -HLVGGEGGGLNLYGQSSKGKTTTLRAAASVWGRGSad--pGFIRSWRATANAQEATAAIVTDTLLCLDEIGVAEGRD-- 622  Methylobacter...
jgi:Clos_1294 541 -KLLNHRIFFVHNWGDSRSGKTAALKAALTVWGNPE-----ELMTSFNATNVGLERLACFFNDLPLGIDERQVAGGKQey 614  Alkaliphilus ...
Q8TPL3        195 -RIIGAESILINIYSQTTVGKTLICRLVMSQYGFAPekgnnGLVHAAAGSKSGFESLLYGYNDRPVYFDESKSEDKEEkn 273  Methanosarcin...
Q8TNP8        300 -KIIDAPSFILHQYFESSGSKTLTTKIALSLIGNPE-----LLCRSANSTDIGIEQTAIQNTDVVLAFDETTRNPQ---- 369  Methanosarcin...
Q5HK55        198 kHETEFAGIIFSFTGQSSTGKSTAASLAVSVAGNPTkg-neTLFRNWNATRNALEGYLSNNFGIPIVFDELSSATFRD-- 274  Staphylococcu...
Q5HK67        194 hNNVEFSGTIFSFTGQSSTGKSTAAMLAASVAGNPTkg-teNLFRSWNATRNALEGYLSGNYGVPIVLDELSAATFHD-- 270  Staphylococcu...
Q8ZMQ9        316 -RLTGTGGGGFHLRGESTDGKTTVMKVAASVCGGTD------YWHSWRATGNALEGIASRHNDALLPLDELREVDPRE-- 386  Salmonella en...
Q7MPU9        214 -QLCGVDGFGLHLYGASSTGKTAALYPALSVWGEPN-----QLRHSWRATANGLEGTALAHNDALLALDEMGEVDPKE-- 285  Vibrio vulnif...
Q4K6S5        594 -NLLGHESGGFHFYGDSSGGKTTHLQVAASVYGGPR------LVRSWRSTDNALESIAAAHSDGLLVLDEIGMCDARI-- 664  Pseudomonas p...
Q01TT1        437 VAKI-MYEVANGQGRGRGNVRSTAylRTWR 465  Candidatus Solibacter usitatus Ellin6076
jgi:M446_0810 623 AAAA-VYQLASGVGKGRAARDGHI--RSPM 649  Methylobacterium sp. 4-46
jgi:Clos_1294 615 IETL-VYMLAMGYSKVRGAKTGGL--QSQK 641  Alkaliphilus oremlandii OhILAs
Q8TPL3        274 SAGLsIYDIVNGLSRILSNQDNTV--KNSR 301  Methanosarcina acetivorans
Q8TNP8        370 FRQN-VYNLVNGVSRNRGTIKNNEv-RAAN 397  Methanosarcina acetivorans
Q5HK55        275 TTGL-LYSITEGQGRQRSNVHGEV--KTPK 301  Staphylococcus epidermidis RP62A
Q5HK67        271 TTGL-LYSFAEGQGRQRANINGDV--KTPK 297  Staphylococcus epidermidis RP62A
Q8ZMQ9        387 AGMI-AYMLANGQGKGRARTDGEV--RNRR 413  Salmonella enterica subsp. enterica serovar Typhimurium
Q7MPU9        286 AGDV-AYMLANGQGKTRAGKYGEM--RLPA 312  Vibrio vulnificus YJ016
Q4K6S5        665 IGET-VYMLGNGTGKARANDRGQAg-RQVQ 692  Pseudomonas protegens Pf-5
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