Conserved Protein Domain Family
Csa1
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pfam06023: Csa1 
CRISPR-associated exonuclease Csa1
CRISPR (clustered regularly interspaced short palindromic repeats) elements and cas (CRISPR-associated) genes are widespread in Bacteria and Archaea. The CRISPR/Cas system operates as a defense mechanism against mobile genetic elements (i.e., viruses or plasmids). Csa1 is part of the archaeal subtype I-A system. Cas1 has not yet been enzymatically characterized.
Links
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Statistics
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PSSM-Id: 283640
Aligned: 7 rows
Threshold Bit Score: 322.526
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q97YD4   1 MFFTHSDM--LLLsKRIKKL--PKNVDEELRGWNWSEPPVYTRSL-SQVSISEMV--YCSTLRNVYLK-VKGFRGEIGRQ 72  Saccharolobus solfata...
O28400   1 MVYFLNELehKFLtLELRPRirQNPVPEELRGWNWHSPPLKPYYN-VKLPMYLICsrYCPTSRDVYLTmVEKVRGEESFP 79  Archaeoglobus fulgidus
Q977B6   1 MFFTLSEI--QLLsKRMKGF--PRAISEELRGWHWNEPPLYPSSN-TLLSVSDLTngLCDSGRYVYLK-HKGIVPKVEAK 74  Sulfurisphaera tokodaii
Q8ZZU0   1 MFREFRMV--RGL---------RVEVGEELRGWRWGEPPVQPPPLgVRLSVSDIVggGCESRRDLYLKrVLGVRAEPNGG 69  Pyrobaculum aerophilum
Q9YCL7   1 MFP-------RGL-WDLVRSsaGDGVYAELRGWKWNV--VGPRYA-ARPTLSDVTg-VCPVGRDTYLRrVLNTRVN-GGL 67  Aeropyrum pernix
Q97Y83   1 MRSQIV----RQL-RRLHSYraSDPIEEELRGWNYYMPPIKPRRY-LGLSISDVAykYCETKRDVYLRkVLKIQGEQRTP 74  Saccharolobus solfata...
Q8ZZL7   1 MLTLQEIA--RLL-RRAKITwgPVEISPEYRGWNYDKPPVKPPAY-LGLALSDFAygYCPTGRNIYLKyVLGERGAAVKA 76  Pyrobaculum aerophilum

Q97YD4  73 ILQGSLIHTIYAIGIEAIKRFIYSRESIDGSTLRTLMgdefysllk-dlreeegiYAKVLWDHITNIYSAELDRVR---S 148 Saccharolobus solfata...
O28400  80 VSLGKAIHEAVAKAIREAKSKNFSAEPPNYDNEMINV------------------AVKAVWEYTMSLCQSSYLKVR---S 138 Archaeoglobus fulgidus
Q977B6  75 I--GNTIHTTYATAIETIKRLIYEHEDLDSVKLRTLMtdefynl-----kvevieVAKILWDHIVSIYSAELEKAR---S 144 Sulfurisphaera tokodaii
Q8ZZU0  70 MKFGAYIHEVFKRSLAELRSLIEGGAVKGWELVQSFNaeaiareaaiaaeaeadpRGVELARYLAIQVAARVDEIA---S 146 Pyrobaculum aerophilum
Q9YCL7  68 LRLGALVHEAFLLPFKAHRVG----------------------------------DAYRMFNYLLRRVRARGNEIRvmnA 113 Aeropyrum pernix
Q97Y83  75 LLLGQAIHEIVRNVSNEVVKLLSSGYKPWSVLETLFRnnkivrsl---cppqfikYCEEVYKAYALDLLSDFSD------ 145 Saccharolobus solfata...
Q8ZZL7  77 LVEGQALHQALFKALEDYKKYAYSGHPMSPSFEgvpe--------------dvrpKAEALYKYVATRLLGEHSYVS---A 139 Pyrobaculum aerophilum

Q97YD4 149 KFTNLTRDSLVSQV--VPFYVEFPVDGSLLGL-TNLRVDAFIPHLP--LIAEMKTGKYRYTHELSLAGYALAIESQYEIP 223 Saccharolobus solfata...
O28400 139 EQPYATEEGVLLTS--MPFLVEHRMDGSLLGCsGLISVDCYDYLRN--VVFDLKVGEFNEEMRLYTTGYALVLESIHEIP 214 Archaeoglobus fulgidus
Q977B6 145 K-PFLRKDSLASLV--IPFHVEYPVDGSLVGLqSALRVDAFIPILP--LIAEMKTGSYKRDHELALAGYALAFESQYEIP 219 Sulfurisphaera tokodaii
Q8ZZU0 147 R-SSADSLSIAARA--VPVLAEYVIDGRPLGLt-LVRADA--LYYN--VVVEIKVGSYSERHALALAGYALAIEADEEVP 218 Pyrobaculum aerophilum
Q9YCL7 114 VFEKAVEFSAAARVdgIPVAVEPNVPGGPVGLsDYVRPDLLVGIMPvdLVLAGHGDRWVARKELAIAGYALAVEAWTGNP 193 Aeropyrum pernix
Q97Y83 146 --------STSF----IPVISEFKVDGSPLGLsSRLSVDA-IMQLS--LVVEMKVGSVQEFHRLALAGYGMALESALELP 210 Saccharolobus solfata...
Q8ZZL7 140 ARLARSRDSAVFYT--APIATQVAVDGSPLGMs-YVVADG--VALG--AVIEFKFGPAQNV-DAALAGYAMAIEADWGVP 211 Pyrobaculum aerophilum

Q97YD4 224 IDFGYLCYVtVTEKEV-KNNCKLIPISDSLRSEFLDMRDKAQDIMDKGVDPGIAKDCESDCMFYKVCh----P 291 Saccharolobus solfataricus P2
O28400 215 VDVGCIISI-TFNGERmRVSKDLHYIDANLRSWWIEERDRKAEIVFNEADPGVAKSCSSNCLFNAFC-----L 281 Archaeoglobus fulgidus
Q977B6 220 VDFGYLCYVnVIEGKI-HNNCRLIVISDTLRQEFVEVRDRALRAIDDDVDPGLAKKCSADCPFLPHCk---gG 288 Sulfurisphaera tokodaii
Q8ZZU0 219 VDAGLLISV-AFNGGV-KLRAYPVAIGEGLRREFLEERNRLMELVASGSDPGLSPKCDDKCPLWRHChg-gsG 288 Pyrobaculum aerophilum
Q9YCL7 194 VDYGVVVGL-RVNDGL-KIVWRLVRVDDHLRTRFLERRDAVARIIEYRSDPGLPEACPPGCVFREVCg----V 260 Aeropyrum pernix
Q97Y83 211 IDFGALIYVnGINTSSpEFKVEVFYVSPDMRKEFLDARDEVIDMISQEKDPGMPVSCSPSCPFLNYCnn-nkR 282 Saccharolobus solfataricus
Q8ZZL7 212 IDYGIHVQI-TVNSTV-EYKATAYPLGDSARTKFLELRDEAIDIVIAGRDPGVAPDCPKTCPFYHIChadrsR 282 Pyrobaculum aerophilum
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