Conserved Protein Domain Family
Myosin_TH1

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pfam06017: Myosin_TH1 (This model is not part of the current CDD release)
Unconventional myosin tail, actin- and lipid-binding
Unconventional myosins, ie those that are not found in muscle, have the common, classical-type head domain, sometimes a neck with the IQ calmodulin-binding motifs, and then non-standard tails. These tails determine the subcellular localisation of the unconventional myosins and also help determine their individual functions. The family carries several different unconventional myosins, eg. Myo1f is expressed mainly in immune cells as well as in the inner ear where it can be associated with deafness, Myo1d has a lipid-binding module in their tail and is implicated in endosome vesicle recycling in epithelial cells. Myo1a, b, c and g from various eukaryotes are also found in this family.
Statistics
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PSSM-Id: 517074
Aligned: 159 rows
Threshold Bit Score: 94.9699
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007405149  783 RRRFSMlgSRKFLGDYLNVggggkagksALG---QMLATKMG-LsSGENVVFSGKgqllVSKLGRSS-KPSPRFLVLTNK 857 
XP_004991101  880 SYPISV--GQPFVGDHVGL---------HVGevaPKWRKVAE-QtKSSEVLFAQR----VEKINRTNgHVVDRVLILCPT 943 
Q8T6L6       1075 SYGRSV--GHPFVGDYVRL---------RHN---QQWKKICA-EtNDQYVVFADI----INKIARSSgKFVPILLVLSTS 1135 fruit fly
O88329        860 SYPQSV--PIPFRGDYIGL---------QGN---PKLQRL-K-GrEEGPVLVADT----VKKVNRGNgKTSARILLLTKG 919  house mouse
4_pfamImport    1 LYQKSL--SQPFKGEYLGL---------KEN---PKYRKLQStA--DGKLVMADN----VKKVNRGDgKASTRIFILTKS 60  
XP_069053319  983 LYLSSV--SQPFKGDYLEI---------SKN---PKYQKLSSaV--EEKIILADT----VNKVNRANgKGAPRIFLLTKS 1042
XP_005986252  863 LYPISV--PQLFQGEYLTM---------QKS---TKYQKLSStI--EEKIIVADT----VLKINRTNgKSSPRICLLTKS 922 
XP_011609839  893 LYPSSV--NQPFKGDYLEI---------GKN---PKYQKLSSaV--DEKVLLADV----VNKINRANgKGTARIFLLTKN 952  torafugu
XP_063122649  808 LYPSSV--GQPFQGAYLEI---------NKN---PKYKKLKDaI--EEKIIIAEV----VNKINRANgKSTSRIFLLTNN 867  Norway rat
XP_056653796  760 SYPESV--PVPFRGDYVML---------HGK---PKLQKA-G----DGPVLMAET----VNKVNRADgKMVPRILLLTKS 816  gray short-ta...
XP_007405149  858 ALYILvtQLVAGsdgqkRQDTMVERKINTSSITSVGLSNLRDDW----MAVNVGH--S----EEPDPVLSCIFKTELVTH 927 
XP_004991101  944 QLLIL------------DEKMKLKYCVDLADVEQLSATTQSDTL----VVIHVAPdrEkkstAKGDHMFYCRSLIEFATR 1007
Q8T6L6       1136 SLLLL--DQRTL---------QIKYRVPASEIYRMSLSPYLDDI----AVFHVKA--SefgrKKGDFVFQTGHVIEIVTK 1198 fruit fly
O88329        920 HVILT--DAKKS---------QAQIVIGLEDVAGVSVSSLQDGL----FSLHLSEm-Ssa-vSKGDILLVSDHVVELLTK 982  house mouse
4_pfamImport   61 HIILA--DPKAA---------QPKTVITLSDIDSVSVTRYSDGC----FVLHIRE--SstagTKGDFLLISDHLIELITR 123 
XP_069053319 1043 NFILA--DPKSG---------QIKSSVPLEDITSVSVSTQSDGF----FALRLKE--GsaaaLKGDFLLSSERLIEIVTK 1105
XP_005986252  923 YFVLA--DVKSA---------QIKTAINLHDISSVSVSHYSDGL----FALHLNE--RssvgTKGDYLLISDHLIEVITK 985 
XP_011609839  953 RVFLA-----DQkt------gQVKASVPLPDLASVSVSTQADGF----FALKLKE--GsasaIKGDFLLSSDHLIEIITK 1015 torafugu
XP_063122649  868 NLLLA--DQKSG---------QIKSEVPLVDVTKVSMSSQNDGF----FAVHLKE--GseaaSKGDFLFSSDHLIEMATK 930  Norway rat
XP_056653796  817 HVILA---DAKG--------SKVKSVIGLESVDEV--SVSSLQNglfgLHLSEISsvG----SKGDFLLVSEHAIELLTK 879  gray short-ta...
XP_007405149  928 LVQQ-----SN-GSITVNIGPLVQFRKKKDKMATIKFQK----DE-TIq-KSDVYKSHTVSVAS-GLP 982 
XP_004991101 1008 LDIAyrkhcNA-KRLKMTISDSFEIQIDKRGTTTVNIERgeadAQqTR--IQKSKHALRLFIPP-AQF 1071
Q8T6L6       1199 MFLViqnatGKpPEIHISTEFEANFGQQT---------------------VIFSFKYGGMSDLAqGPP 1245 fruit fly
O88329        983 MYQAvldatQR--QLSVTVTEKFSVRFKE-GSVAVKVIQ----GP-----EGGGNRKLICKKKGsNAM 1038 house mouse
4_pfamImport  124 LHQTvldttKQ--KLKLQVADEFVVKFKQ-SSIAVKAVE-----------TAVKQGTGPVFRKKgNRR 177 
XP_069053319 1106 LHRSgaggdRP--QIGVDIVDEFLVQFKQ-DKVCVKFIPggpkNGnSAtcRRKNNRLLEVAVPS---P 1167
XP_005986252  986 LHRTatettKQ--KMNLHILDEFKVKFKR-DEVLIKFVE-----------AVAKNGNGAVCKKKsSHM 1039
XP_011609839 1016 LHRTgataaDR-EELNIDISDEFLVQFKQ-DKVCVKFIQ-------GAskNGN-----GASCKRkNNR 1069 torafugu
XP_063122649  931 LYRTtlsqtKQ--KLNIEISDEFLVQFRQ-DKVCVKFIQ-------------GNQKNGSVPTCKrKNN 982  Norway rat
XP_056653796  880 LYQAtldkmKR--PLPITVTEEFTVKFKE-GNLTVKVTE----SQ-----MGKGNNKLSCKKKGhNQL 935  gray short-tailed opossum
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