Conserved Protein Domain Family
Herpes_U5

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pfam05999: Herpes_U5 
Herpesvirus U5-like family
This family of Herpesvirus includes U5, U7 and UL27. UL27 promotes a cell cycle arrest in G0/G1 by inducing the proteasomal degradation of host histone acetyltransferase KAT5/Tip60.
Statistics
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PSSM-Id: 283619
Aligned: 2 rows
Threshold Bit Score: 681.501
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6SWA4 163 VHEAQYLPEISRAAKRIALAVATGQYVVCTLLDYKTFGTRTHYLRQLCSMTEELYLRLDGTLCLFLEPEERELIGrclpA 242 Human herpesvirus 5 s...
Q9QJ54 462 VKNLKFMDNFDEKWQCITKLAFIGLYAGASLFNFASKPTLGYWCRYLCEYASMLLFQFESKLKELTKESTRQLGG----Y 537 Human herpesvirus 6 s...
Q6SWA4 243 ALCR-GLPVK-YRTHRAAVFFHATFMARAEAALKDLYAAFCECGDGRD-----DGGNHNGNYGggdhsslspsavasHHS 315 Human herpesvirus 5 s...
Q9QJ54 538 NLCHwGQELKdCLENKSDVFFRYDFFERIESCLIEHFMLLCGCVECRRmfimyNKRGRKCDFG--------------HCV 603 Human herpesvirus 6 s...
Q6SWA4 316 RLEHAELrlernrhLGAFHLPAIRHLTAGDVARVQDSVSRDLGFadwsqTLVD---DYFLLPAGWACA-NPRRGYAMYLA 391 Human herpesvirus 5 s...
Q9QJ54 604 RIQCFPM-------IGSIRLPAFLHLGEPYSVSLSSLIAKDLGL-----SMIEgqiEHSRLPISLQISvTPDKKALLTFL 671 Human herpesvirus 6 s...
Q6SWA4 392 SNAVLALRIIRLLRASIRHEYTACIRMLSGDVQRLIRLFKGEAALLRKGLAqnpvqrRELSRFR--KHVHDLKRIRFTED 469 Human herpesvirus 5 s...
Q9QJ54 672 TNIVFIVFVVNTLYRVINAELDIYYDLFTEEVGKLCVTMEEEMKLGRNGCL------GDLCYFSsmKQMKEIVRCPGEKS 745 Human herpesvirus 6 s...
Q6SWA4 470 TFVETFCDFLELVQRIPDYRSVSLRIKRELLCLHVFKLRR-----------------GCRAPPTPEAVRVQRLlwhslrh 532 Human herpesvirus 5 s...
Q9QJ54 746 QFILKCWEALRIGFSVPAYKDYDETRFMEMFFLHHLHIKRfhehndrdlvssdnlipGFFIVNTHEENFLQRL------- 818 Human herpesvirus 6 s...
Q6SWA4 533 gdapqDRTRLPQ-----------------FSSALSDAELSNHAnrcrrkaplelgpAVVAAPGPSVRYRAHiqKFERLHV 595 Human herpesvirus 5 s...
Q9QJ54 819 -----QRVVLPVaedyltntrcingtmafFFSGLKYFGSGNHR-------------GVQISPEKDVRAIGY--KLGSLDV 878 Human herpesvirus 6 s...
Q6SWA4 596 RRfRPHEV 603 Human herpesvirus 5 strain Merlin
Q9QJ54 879 LR-DDYKY 885 Human herpesvirus 6 strain Z29
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