2DKE,2G18


Conserved Protein Domain Family
Fe_bilin_red

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pfam05996: Fe_bilin_red 
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Ferredoxin-dependent bilin reductase
This family consists of several different but closely related proteins which include phycocyanobilin:ferredoxin oxidoreductase EC:1.3.7.5 (PcyA), 15,16-dihydrobiliverdin:ferredoxin oxidoreductase EC:1.3.7.2 (PebA) and phycoerythrobilin:ferredoxin oxidoreductase EC:1.3.7.3 (PebB). Phytobilins are linear tetrapyrrole precursors of the light-harvesting prosthetic groups of the phytochrome photoreceptors of plants and the phycobiliprotein photosynthetic antennae of cyanobacteria, red algae, and cryptomonads. It is known that that phytobilins are synthesized from heme via the intermediary of biliverdin IX alpha (BV), which is reduced subsequently by ferredoxin-dependent bilin reductases with different double-bond specificities.
Statistics
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PSSM-Id: 399177
Aligned: 26 rows
Threshold Bit Score: 213.238
Threshold Setting Gi: 144578326
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DKE_A           25 ALAIAASWQSl-PLKPYQLPEDLGYVEGRLEGEKLVIENRCYQTPQFRKMHLELAKVGKGLDILHCVMFPEPLY-GLPLF 102 Synechocysti...
jgi:OSTLU_15568  65 RTTLRARCGE--GLEEARVDDAFAARANAKR--GVTTTTEAWSSRRLRRVRSTYVDGGEKAQIYNCAVYPACEAcDAPVF 140 Ostreococcus...
Q7NL66            6 LEHLQQKLQSsfDLQSLTIPAGLDYRISERGRESTTIRSWCYTCSELRKIRYTYIDGGEHAQVFNSVIYPAHRY-DLPLL 84  Gloeobacter ...
Q10UW5            6 LEYLEKELFSkfDLRSRPIPAGLEANVSNRGKNKARIQSWCYECTELRKIRYTYIDAGATAQVFNSVIYPSYCY-DIPLL 84  Trichodesmiu...
Q7V586           10 HSSIRIQ-----GGETAAVPDGLRECRNEKK--NSWIRSWLWQVPGFRRWRVSRLDAGESLQVLNSVAYPNYNI-DQPLM 81  Prochlorococ...
CAK28964         10 HDSIRAR-----GGQPTAVPAGLEECQSAKG---SVIRSWLWDVPGFRRWRVSRMDAGDSLQVLNSVAYPDFSN-EQPLM 80  Synechococcu...
A5GIZ3           10 HQGIHQR-----GGQPAAVPEGLEHCHSSKS--GGSIDSWLWSVPGFRRWRVTRLDAGESLQVLNSVAYPDHSL-DHPLM 81  Synechococcu...
Q9K4U6           10 HNNLKRRIISh-GGKPIEVENGMSERFSHKQ--DTVIKSWLWDVPGFRRWRVTRMDAGDKLQVLNSVAYPAYTN-DKPIL 85  Prochlorococ...
Q9SR43           55 AESALEETRKriVLEPSHLQEKYSSMTGLDG--KTELQMLAFKSSKIRLLRSMAIE-NETMQVFDFAGFMEPEY-DTPIF 130 thale cress
XP_001752723    125 lEYAVRAVEQraDISPLPCQGEFQNMVAADG--QSVVKNVAFESTKFRLFRCATINGGDNMQVLNVAICARPEY-DLPIF 201 Physcomitrel...
2DKE_A          103 GCDI--VAGPGG-VSAaiADLSPT---QSDrqLPAAYQKSLAELG---------Q--PEFEQQRELPPWGE-IFSEYCLF 164 Synechocysti...
jgi:OSTLU_15568 141 GVDLicVGVGAArKILigVDLQPM---SRDrdYNDAYVPKLLKLRdggalsacaEalNATTPSKKFYEDAT-YFSRGMFF 216 Ostreococcus...
Q7NL66           85 GIDL--LAFGKKkNLIv-LDFQPL---FRDkaYLARYIEPMRILRe--------RygDVAQDVEMKFYDANqYFSKYLLF 150 Gloeobacter ...
Q10UW5           85 GIDL--LSFGKNkILIv-LDFQPL---FQEesYLAKYIEPMRSLRe--------KynDLAQNLEMKFYDANqYFSKYLLF 150 Trichodesmiu...
Q7V586           82 GLDL--LWFGKRqKLVaiLDFQPL---IQDqsYLERHFQGLKTLQn--------RfpELSGEETMRLFDPNqYFSPWLLF 148 Prochlorococ...
CAK28964         81 GVDL--LWFGGRqKLVavLDFQPL---QQDkdYLEHQLQDLRALHq--------RfpELSGEETMRSFDPNqYFSPWLLF 147 Synechococcu...
A5GIZ3           82 GVDL--LWFGARqKLVavLDFQPL---IQDqdYLDRHFQGLKALHe--------RfpELNGEETMRSFDPNqYFSPWLLF 148 Synechococcu...
Q9K4U6           86 GIDI--LWFGLKrKLVavLDFQPL---VQEerYFCRYYKDLQILKn--------RfvDFNSQKTMKIYDSNkYFSPWVLL 152 Prochlorococ...
Q9SR43          131 CANF--FTSTNVnIVV--LDLNPLhqlTDQtdYQDKYYNKIMSIYh--------KyaETFPWGGKLTGESIkFFSPLVMW 198 thale cress
XP_001752723    202 CADF--FSTARMnIVV--LDLNPLyntEQRpeYKEKYYSRILPLGn--------KyaELLPWGDKLTAESIqFFSPIVLW 269 Physcomitrel...
2DKE_A          165 IR--PSNVTEEERFVQRVVDFLQIHCHQSIVAEPLse-------aQ------------------TLEHRQGQIHYCQQQQ 217 Synechocysti...
jgi:OSTLU_15568 217 ARpaLANEETMARSLDVVRAYLDVWLDRLDEAEREae------amDgackfglsledvrrcvltEASAREAQDAHDAWQL 290 Ostreococcus...
Q7NL66          151 AR--TDAETVAGRVFTAYCDYLDLYWQLLASAAPLgd------aqD------------------IRRIVKAQKDYDQYSA 204 Gloeobacter ...
Q10UW5          151 AK--TDAQTVQTKFFQAYKDYISLYWQMLHEAEIIqt------eaE------------------IQKIVKAQKDYDQYSA 204 Trichodesmiu...
Q7V586          149 CR--GGAEKATNSLPEAFNAFLHCYWELHQQNSDKas------liP------------------AAEVKQLQIAYDIYSA 202 Prochlorococ...
CAK28964        148 CR--GGAEEATRSLPQAFSAFLTSYWALTERSKTTts------tlP------------------PAEVEQLQIAYDRYSA 201 Synechococcu...
A5GIZ3          149 CR--GGAQEAEESLPAAFDAFLTAYWAMHDQALDVeaagtsastlS------------------INDVERLQEAYDVYSA 208 Synechococcu...
Q9K4U6          153 YN--GSFDDLQCSLAKILDEFLHAYWQVDNNNSREyi------kiI------------------PSKVEQLHINYDIYSA 206 Prochlorococ...
Q9SR43          199 TRf-SSSKEKHKALFSAFLEYYQAWLEMTIQVREEme------psH------------------VRANCEAQHKYLTWRA 253 thale cress
XP_001752723    270 TRp-ASREEIQETVFRAFKDYLDAWLDMADKANPSnd------ayE------------------IAENQESHHRYLMWRA 324 Physcomitrel...
2DKE_A          218 KNDKTRRVLEKAFGEAWAERYMSQVLFD 245 Synechocystis sp. PCC 6803
jgi:OSTLU_15568 291 EHDPAIAMFASWYGEEWARDFAETVLFP 318 Ostreococcus lucimarinus CCE9901
Q7NL66          205 DRDPASGLFSSYFGHEWAERFLYEFLFE 232 Gloeobacter violaceus PCC 7421
Q10UW5          205 ERDPASGLFSSYFGHEWSEKFLYQFLFE 232 Trichodesmium erythraeum IMS101
Q7V586          203 ERDPAHGLFTSHFGKAWSDRFLHEFLFP 230 Prochlorococcus marinus str. MIT 9313
CAK28964        202 ERDPAHGLFTSHFGKEWSDRFLHEFLFP 229 Synechococcus sp. RCC307
A5GIZ3          209 ERDPAHGLFTSHFGKDWSDRFLHEFLFP 236 Synechococcus sp. WH 7803
Q9K4U6          207 ERDPAHGLFKSYFGQTWADQFVREFLFP 234 Prochlorococcus marinus subsp. marinus str. CCMP1375
Q9SR43          254 QKDPGHGLLKRLVGEAKAKELLRDFLFN 281 thale cress
XP_001752723    325 TKDPGRYLLMRLFGEPLCERYITEFLFN 352 Physcomitrella patens
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