5MQ9


Conserved Protein Domain Family
NYN_YacP

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pfam05991: NYN_YacP 
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YacP-like NYN domain
This family consists of bacterial proteins related to YacP. This family is uncharacterized functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind. Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA.
Statistics
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PSSM-Id: 399173
Aligned: 50 rows
Threshold Bit Score: 137.321
Threshold Setting Gi: 504774695
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MQ9_B            4 LLVDGYNMIGA-----WPQLKDLK-ANSFEEARDVLIQKMAEYQSYTG--NRVIVVFDAHLVKGLEKKQTNH-----RVE 70  Bacillus sub...
Q1AU13            5 LILDGYNLIGA-----LERYGTGKtGG-LDESRERLVNDALKAAGWTG--RRVIVVFDAHGSPEPEREEVRAg---gAVR 73  Rubrobacter ...
Q2JJU0            9 LLVDGYNIIGA-----WPTLNQLArRSLMELARLRLVESLANYVAFRG--YQATVVYDAYAQPTPARQERSPs----GIE 77  Synechococcu...
Q7NCI6            5 LLVDGYNVVGA-----WPRLARLRdRHSLEAARNELVEQLAGYASFRG--YRAVLVFDAQLVTSPLVRASETp----HLE 73  Gloeobacter ...
EAW44815         10 LLVDGYNIIGA-----WPCLKKTRdHAGLEAARWELVEAMTNYSSFQG--YETQIVFDAQYHQASSNQEIITe----LLS 78  Nodularia sp...
WP_014961797      5 VLIDGYNVIGS-----EGRFRKDRd--ILARERENLIRRLSEYRSLLApdTEIQLIFDGFPSDR-DPFRHRGg----GVT 72  Leptospirill...
Q2LWS1            3 IIIDGYNLIRQ-----SDFLRHFErRS-LEAGRQALLSQVSSYRKSKG--HRITVVFDGWENGSPFEERDRQg----GIT 70  Syntrophus a...
Q8F3Z2           47 vAIDGFNLIYK-----FPDLEESMyQNRLSDARRTLLEWIELYSKKKKk-QNFHIFFDGKKEIGNEVLQETFg----KLN 116 Leptospira i...
jgi:Paes_2273     8 FIIDGYNLLHA--------RGLQApALTLEEQRTRLEANLIRAQERKH--CKITVVYDGRSHGRALSEAg-------ALN 70  Prosthecochl...
jgi:OSTLU_30756 144 LLVDGYNVCGLegadgVEEANAAFrRGDMDAARVALTKEVMDFKSFSG--YAVALVWDADRNRDKDEDEIEGdldvdGFM 221 Ostreococcus...
5MQ9_B           71 VIFTKENETADERIEKLAQALNNiA-----TQIHVATSDYTEQWAIFGQGALRKSARELLREVETIERRIE-R------- 137 Bacillus sub...
Q1AU13           74 LVFSGPGQSADDVIERLLSRLEE-------GSATVYTGDFALQRTVLARGARRATPREFQGLLDELP------------- 133 Rubrobacter ...
Q2JJU0           78 ILYTSYGETADSCIERLCAQLQKdG-----CRVRVATSDRVQQLVIGGYNAEWVSAEQLWDEVQQAQQQIR-H------- 144 Synechococcu...
Q7NCI6           74 VCFTDYEQTADSFIEQYSYQLLReNr---rRRVMVATSDRAQQVLVLAQGADWLSSEQLLKEVEAARRQLR-E------- 142 Gloeobacter ...
EAW44815         79 VHYTDFGQTADTYIEKSCASLRYkIaqsliHRVIVATSDRAQQLMVQGYGAEWLSAQQLCGEVETTICRMR-H------- 150 Nodularia sp...
WP_014961797     73 VLFSEEEGSADAVIVRLSERFGN--------RAIVVTSDREVILRVRQSGAQAVGAREFMERVGARRTSAS-Hti----r 139 Leptospirill...
Q2LWS1           71 VVYSRRGEKADEVIKRMVLQKG--------EEIVVVTSDRDVADYISRKGATALTSPEFEEVIVRAAASAAvTavaerfp 142 Syntrophus a...
Q8F3Z2          117 VYYSRD-RKADDLIKEFVRTQIR-P-----ADVQVVSSDKEIFYHAKKWGAHPITSEEFASIVTAEIFPSK--------- 180 Leptospira i...
jgi:Paes_2273    71 KVFTASKMTADEWIIDFLRSSPKrA-----RQLTVVSSDRLIVSHASAYGAACMSSEAFASSHLEESPTK---------- 135 Prosthecochl...
jgi:OSTLU_30756 222 TVYSVK-NDADSWIEARVAQEIGaDkk-snRVVYVATSDNALSSIARGTGAYVVTAKAFVEELRKASQGEK--------- 290 Ostreococcus...
5MQ9_B          138 -RVRK----ITS--EKPAGKIALSEEVLKTFEKLRR 166 Bacillus subtilis subsp. subtilis str. 168
Q1AU13          134 -AVVR----SPDrsRRSKVADRLSPETLRRLEEIRR 164 Rubrobacter xylanophilus DSM 9941
Q2JJU0          145 -LQPK----R-Ls-SKRGIDAYLDAETLSRLNRWRl 173 Synechococcus sp. JA-2-3B'a(2-13)
Q7NCI6          143 -DLRN----RKAr-PSNKLADRLDPTVRDKLARWRF 172 Gloeobacter violaceus
EAW44815        151 -KYQQ----RKQs-KSRFLANSIDAKARQRLAELRM 180 Nodularia spumigena CCY9414
WP_014961797    140 nEKPE----DEDe-DPRPQTKKGNPRRLSKKERARR 170 Leptospirillum ferriphilum
Q2LWS1          143 eKEEEddarESGnaRKKGPAHRLSRREKAAMTRRRK 178 Syntrophus aciditrophicus SB
Q8F3Z2          181 ---------QKTd-LEELKDKKLSSEELEYWKNLFR 206 Leptospira interrogans
jgi:Paes_2273   136 -RNNT----ARSehAGKHGDKPLSDREVNAWMKLFD 166 Prosthecochloris aestuarii DSM 271
jgi:OSTLU_30756 291 -EILQ----EMAiaARWNSSKKMSNVGVRD-DDVKR 320 Ostreococcus lucimarinus CCE9901
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