3GHM


Conserved Protein Domain Family
ADAMTS_spacer1
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pfam05986: ADAMTS_spacer1 (This model is not part of the current CDD release)
ADAM-TS Spacer 1
This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organisation among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Links
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Statistics
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PSSM-Id: 517059
Aligned: 44 rows
Threshold Bit Score: 111.522
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3GHM_A  273 PRKGSFTAGR-AREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGG-RYVVAGKMSISpNTTYPSLLEDGrVEYRVal 348  human
Q9W493  791 TYTDPFAAK--DGAYVEIVTIPARARHILIRELANSPHFLAIAtgDGGdRFYLNGDSLIS-MPGEFEIAGAE-SLYDR-- 864  fruit fly
P58397  703 TVRKMFKQKE-GSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRseDPE-KYYLNGGFIIQ-WNGNYKLAGTV-FQYDR-- 776  human
Q8TE59  791 IIKGDFNHTR-GAGYVEVLVIPAGARRIKVVEEKPAHSYLALR--DAG-KQSINSDWKIE-HSGAFNLAGTT-VHYVR-- 862  human
Q4VC17  750 FYKGLYLSQHkANEYYPVVTIPAGARSIEIQELQLSSSYLAVRs-LSQ-KYYLTGGWSID-WPGDFTFAGTT-FEYQR-- 823  house mouse
Q8TE57  747 IHRGLYTKHHhTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRn-ALR-RYYLNGHWTVD-WPGRYKFSGTT-FDYRR-- 820  human
O76840  225 TIEGRFDERNlSPGYHDIIKLPEGATNIKIQEARKSTNNLALKn-GSD-HFYLNGNGLIQ-VEKEVEVGGTI-FVYDD-- 298  Caenorhabditis elegans
Q9UKP5  718 AIEGFFNDSLpRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKs-EGD-DYYINGAWTID-WPRKFDVAGTA-FHYKR-- 791  human
P58459  707 TIEGVFSPALpGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKg-DQE-SLLLEGLPGTP-QPHRLPLAGTT-FHLRQ-- 780  house mouse
Q3UTY6  413 VVSGVFKHALtSLGYHRVVEIPQGATKINITEMHKSNNYLALRs-RSG-RSIINGNWAID-RPGKYEGGGTM-FTYKRpn 488  house mouse

3GHM_A  349 tedRLPRLEEIRIWGPLQEDADIQ-VYRRYGeeygnLTRPDITFTYFQP 396  human
Q9W493  865 ----VDEQETITIPQPIQHSISLYaIVRGN------ESNAGIFYEFTLP 903  fruit fly
P58397  777 ----KGDLEKLMATGPTNESVWIQ-LLFQ-------VTNPGIKYEYTIQ 813  human
Q8TE59  863 ----RGLWEKISAKGPTTAPLHLLvLLFQ-------DQNYGLHYEYTIP 900  human
Q4VC17  824 ---SFNRPERLYAPGPTNETLVFE-ILTQ-------GKNPGIAWKYALP 861  house mouse
Q8TE57  821 ---SYNEPENLIATGPTNETLIVE-LLFQ-------GRNPGVAWEYSMP 858  human
O76840  299 -----AEPETLSAQGPLSEELTVA-LLFRKG-----SRDTAIKYEFSIP 336  Caenorhabditis elegans
Q9UKP5  792 ---PTDEPESLEALGPTSENLIVM-VLLQ-------EQNLGIRYKFNVP 829  human
P58459  781 ---GPDQAQSLEALGPINASLIIM-VLAQ-------AELPALHYRFNAP 818  house mouse
Q3UTY6  489 -evSSTAGESFLAEGPTNEILDVY-MIHQ-------QPNPGVHYEYVIM 528  house mouse
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