Conserved Protein Domain Family
Sbt_1
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pfam05982: Sbt_1 
Na+-dependent bicarbonate transporter superfamily
Family of bacterial proteins that are likely to be part of the Na(+)-dependent bicarbonate transporter (sbt) family. Members carry 10TMS in a 5+5 duplicated structure. The loop between helices 5 and 6 in Synechocystis PCC6803 is likely to be the location for regulatory mechanisms governing the activation of the transporter.
Links
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Statistics
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PSSM-Id: 488068
Aligned: 73 rows
Threshold Bit Score: 262.801
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q73XV2          16 PlLLFFYFGFLIPILKVRFEFPYVIYQGLTMYLLLAIGWHGGEELAQv-sASSVGAIVGFMVLGFVlncaIGGLAYLGLS 94  Mycobacterium...
WP_025311101    18 PtLAFLIGGMALAAFGSKLEIPEPVYKFIVFLLLMKVGLGAGISIREanfIDLAIPAVGAALVGIA----IVLLGSGTLA 93  Roseicyclus e...
WP_015224189    18 PtLGFLIGGMVVAALNSRLQIPDAIYKFIVFMLLIKVGLSGGIAIRNanlAQMLLPAVFAAIIGIL----IVFIACNTLA 93  Halothece sp....
WP_015171993    18 PtLGFLIGGMVIAALGSQLQIPDAIYKFIVFMLLIKVGLSGGIAIRNanlVDMLLPALFAVVMGIL----IVFIGRYTLA 93  Geitlerinema ...
Q8YV47          18 PtLGFLIGGMVIAALGSELIIPEAICQIIVFMLLTKIGLTGGIAIRNsnlTEMVLPAASAVAVGVL----VVFIARYTLA 93  Nostoc sp. PC...
WP_015189776    18 PtLAFLIGGIVIAALGSKLEIPDAIYKFIVFMLLIKIGLSGGIAIRNsnlTEMLLPALFAVVTGML----IVFIGRYTLA 93  Gloeocapsa sp...
wustl:cce_2939  25 PtLGFLIGGAVAAAVSSRLAIPDAIYKFIVFMLLIKVGLKGGIAIREsniTEILLPALFAVLTGIL----IVFIARHTLA 100
WP_024267853    18 PtLAFLIGGALIVAMGSRLSIPNSIYQFIIFLLLMRIGMKGGIEIRSaeiGEMLLPAVFSVAVGII----IVLLGTGFFS 93  Salinispira p...
WP_013487399    15 PmILFFLLGIIAVLVNSDLKVPTAFYNGYTMIILFTIGIKGGIELRSvslSEMIPTIITAIVLSIV----MLFIAHLIVH 90  Evansella cel...
WP_012214868    14 PiILFFLFGIIAARIKSDLKIPAAISEFLPIYLLAAIGLHGGIEMRNtgfENMLIPMFVAIGLSLL----FTLNHYQILR 89  Nitrosopumilu...

Q73XV2          95 RLKSLRKVDRATIAGYYGSDSAGTFATCVAVLAAVNIAFNAYMPVMLAVMEIPGCLVALYF-----VARLRHRGMDsagy 169 Mycobacterium...
WP_025311101    94 RLRGVSSMDGMATAGLFGAVSASTLAAGMAMLDEEGIAYEGFIGALYPFMDIAALVTAILL-----ARLSAERKAAaett 168 Roseicyclus e...
WP_015224189    94 KLPKIKTVDAIATGGLFGAVSGSTLAAGITMLESEGLQYEAWAAALYPFMDIPALVTAIVL-----ASIYVGKQRdtage 168 Halothece sp....
WP_015171993    94 KLPKVKTVDAIATAGLFGAVSGSTMAAALTLLEEQGVAYEPWAAALYPFMDIPALVTAIVV-----ASIYISKKRnaase 168 Geitlerinema ...
Q8YV47          94 KLPKVNTVDAIATGGLFGAVSGSTMAAALTLLEEQKIQYEAWAAALYPFMDIPALVTAIVV-----ANIYLNKKKrsaag 168 Nostoc sp. PC...
WP_015189776    94 KLPGIRTVDAVATAGLFGAVSGSTLAAGITVLEAQGIEYEAWAGALYPFMDIPALVTAIVV-----ASIYTSKKKSlreq 168 Gloeocapsa sp...
wustl:cce_2939 101 KLPNIKVVDAIATGGLFGAVSGSTLAAGLAVLDAQGMEYEAWSAALYPFMDIPALVTAIVL-----ASIYTSKQKklaae 175
WP_024267853    94 LLARVRWSDGTATAGLFGAVSSSTLAAAMVLLEEQAVFFEAWVPALYPFMDIPALILAIVL-----SKLGTEKAGtrts- 167 Salinispira p...
WP_013487399    91 RIFKYAIVDSLAIAAHYGSVSAVTFIAGLAFLDKLGITYESYMSAILVVMEGPAIILAIIL-----YKLYSDKQGTeetn 165 Evansella cel...
WP_012214868    90 RLGKFNLFDSYALASTYGAVGAVHFSVGLSFLKNQGVSSEGYIAAILAVLEPLAFILAIFMtnmavAKQIKTKKQSfsdd 169 Nitrosopumilu...

Q73XV2         170 mpdeagytppvrvgvgpgtaarpphgqslqtqe-------------------eaaieqelelsleklehpewqtdpsplr 230 Mycobacterium...
WP_025311101   169 aqpggava----------------------------------------------------------------------vg 178 Roseicyclus e...
WP_015224189   169 vlskqeslskqrvaagevlsehgt-------------------------------------stgdyssvppeypttrqey 211 Halothece sp....
WP_015171993   169 dlnkqeffskqpvaagdysn---------------------------------------------pseypttrqeylsmq 203 Geitlerinema ...
Q8YV47         169 eylskqsvaageypdqq---------------------------------------------------dypssrqeylrk 197 Nostoc sp. PC...
WP_015189776   169 hrtagasfstagesfstasesfstagasfstagasfstagesfstagesfstageypskpeyptsrqeyrsqqritasgy 248 Gloeocapsa sp...
wustl:cce_2939 176 neyrskqefygeqkey-----------------------------------------------------gqqritasgyp 202
WP_024267853       --------------------------------------------------------------------------------     Salinispira p...
WP_013487399       --------------------------------------------------------------------------------     Evansella cel...
WP_012214868   170 steid--------------------------------------------------------------------------- 174 Nitrosopumilu...

Q73XV2         231 gkgtrapifSRELFQEVFLNPGLVLLMGGIIIGLVSG-LqgqKVVADDDKFFVIAFQGVLCLFLLEMGMTASRKLKDLRS 309 Mycobacterium...
WP_025311101   179 kpgsdngemIRGILSETFRSAAISALLLGLALGILARpD------SVYENFYDVLFRGLLSILMLIMGMEAWSRLSELRQ 252 Roseicyclus e...
WP_015224189   212 reqqgkrveIWPIVKESLQGSALSALLLGLALGILTRpE------SVYESFFNPLFRGLLSILMLVMGMEAWARISELRK 285 Halothece sp....
WP_015171993   204 rgdggnrveIWPIVKESLQGSALSALLLGLVLGLLTRpE------SVYESFYDPLFRGLLSILMLIMGMEAWSRLGELRK 277 Geitlerinema ...
Q8YV47         198 qqsadnrvkIWPIVKESLQGPALSAMLLGIALGLFTQpE------SVYKSFYDPLFRGLLSILMLVMGMEAWSRIGELRK 271 Nostoc sp. PC...
WP_015189776   249 pskqrervkIWPIVKESLEGSALSALLLGLALGLLTRpE------SVFESFYEPLFRGLLSILMLVMGMEAWSRLGELRK 322 Gloeocapsa sp...
wustl:cce_2939 203 heeqnhrveIWPIIKDSLQGSALSALLLGLALGLLTRpE------SVYESFYEPLFRGLLSILMIVMGMEATARINELRK 276
WP_024267853   168 -----astrILDVIKESIQGPALSALVLGLALGIFARpE------SVLEGFYNPIFRGLLSVLMFILGMEAYSRIRELKQ 236 Salinispira p...
WP_013487399   166 -----pnagLSHVIKEAFFGKSIFLLLGGIFIGLVAH-L---DGLYLIQPLFGDLFYGFLCIFLLHMGMIATESMKSMKK 236 Evansella cel...
WP_012214868   175 iglnqtktkLSKVLHESITGKAIVILLGSIVIGYIIG-K---DGFEPIKIVFDDMFTGAIVIFMIEMGIIAGQRLDDIKK 250 Nitrosopumilu...

Q73XV2         310 AGWGFIVFGLVAPNVFATLGIFVA---CsYASLThtdfkTGTYVLFAVLCGAASYIAVPAVQRLAIPEASPTLPLAASLG 386 Mycobacterium...
WP_025311101   253 VAHAYIAYGLLAPLAHGALGFGAGlivHqLTGFS-----GGGVVLLAVMAASSSDISGPPTLRGALPEANPSAYVGTSTG 327 Roseicyclus e...
WP_015224189   286 VAQWYAVYAFVAPLLHGLIGFGLGyvaHiTTGFS-----PGGVVILAVIASSSSDISGPPTLRAGIPKANPSAYIGSSTA 360 Halothece sp....
WP_015171993   278 VAQWYAVYAVVAPLLHGFIAFGLGmiaHyATGFT-----PGGVVILAVIACSSSDISGPPTLRAGIPSANPSAYIGASTA 352 Geitlerinema ...
Q8YV47         272 VAQWYVVYSVVAPLVHGFIAFGLGmiaHyATGFS-----LGGVVILAVIAASSSDISGPPTLRAGIPSANPSAYIGASTA 346 Nostoc sp. PC...
WP_015189776   323 VAQWYALYALVAPLLHGFIAFGLGmiaHyATGFS-----PGGIALLAIIACSSSDISGPPTLRAGIPSANPSAYIGASTA 397 Gloeocapsa sp...
wustl:cce_2939 277 VAQWYAVYAFIAPLIHGFIAFGFGmiaHyATGFS-----AGGVVILAIIAASSSDISGPPTLRGGIPSANPSAYIGASTA 351
WP_024267853   237 VAHWFALYALAAPILHGLIGFALGyvaHiLAGFS-----PGGVVLLSVIAASNSDISGPPTLRAGIPSANPSTYIGASTS 311 Salinispira p...
WP_013487399   237 FNPVSFMFAFILPIIGGFLGVIAG---S-ILGLS-----LGGAVILAILTGSASYIAAPAAIQQAMPQANSGLYLGSSLG 307 Evansella cel...
WP_012214868   251 VGVFLTAFAIIIPLFNGTIGVLVS---T-ALGLS-----VGGAVMFGLLMASASFIAAPAVLRHAIPQAKPSLYITSALG 321 Nitrosopumilu...

Q73XV2         387 LTFSYNVTVGIPLYIEI 403 Mycobacterium avium subsp. paratuberculosis
WP_025311101   328 LGTPVAI-LSIPLWIAL 343 Roseicyclus elongatus
WP_015224189   361 VGTPIALAIGIPLFIGL 377 Halothece sp. PCC 7418
WP_015171993   353 IGTPIAIGIGIPLYIGL 369 Geitlerinema sp. PCC 7407
Q8YV47         347 IGTPIAIGLAIPLFLGL 363 Nostoc sp. PCC 7120
WP_015189776   398 IGTPVAIAIGIPLFVGL 414 Gloeocapsa sp. PCC 7428
wustl:cce_2939 352 VGTPVAIALGIPLFIGL 368
WP_024267853   312 IGTPVAIGICIPLFVSL 328 Salinispira pacifica
WP_013487399   308 LTLPFNLIIGIPLYYWL 324 Evansella cellulosilytica
WP_012214868   322 ITFPFNIIVTLPILFTL 338 Nitrosopumilus maritimus
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