Conserved Protein Domain Family
APC_15aa

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pfam05972: APC_15aa 
APC 15 residue motif
This motif, known as the 15 aa repeat, is found in the APC protein family. They are involved in binding beta-catenin along with the pfam05923 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.
Statistics
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PSSM-Id: 461790
Aligned: 10 rows
Threshold Bit Score: 24.0349
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006627072 1158 EEDQPTNYSIKYSEE 1172
Q9VAS9        757 TEEQPIDYSVKYSEN 771  fruit fly
XP_002013429  501 TEEQPIDYSMKYMEH 515 
2_pfamImport    1 ELDTPINYSLKYSDE 15  
XP_002936457 1176 HGEQPIDYSRKYPTD 1190
3_pfamImport    1 HVDQPIDYSLKYATD 15  
Q9VAS9        782 DLDQPTDFSLRYAEN 796  fruit fly
1_pfamImport    1 DLDQPTDFSARYKER 15  
4_pfamImport    1 EEERPTNYSIKYNEE 15  
5_pfamImport    1 EDDKPTNYSERYSEE 15  
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