1YLL


Conserved Protein Domain Family
HutD

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pfam05962: HutD 
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HutD
HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterized repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription. The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.
Statistics
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PSSM-Id: 399154
Aligned: 52 rows
Threshold Bit Score: 125.89
Threshold Setting Gi: 524348134
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YLL_D         11 AVDYPRXPWKNGAGSTEEIard--ggDGLD--G-FGWRLSIADVGES-GGFSGFAGYQRIISVLEGG-GXRLRVDg---- 79  Pseudomonas ae...
WP_012071566   14 QSDYQRMPWKNGLGETLEI-------QRHEdeSgLRFRISQASVVED-GVFSDFNGLHRTLVLLSGE-GMTLEHAvknns 84  Marinomonas sp...
jgi:Sama_0070   8 AKDFVTNDW--AGGSTTQLlih-pkgSSLAarD-FEFRLSCARVEQS-GQFSDFSGYDRLLLVLEGA--MKLSGNal--s 78  Shewanella ama...
CDB02632       14 ITR-----W--AGGRTRQLaiypqdaQGAEafD-FVFEITSSTTDIKeSEYTIYESYNRTLMIISGEsALTLEDG----- 80  Firmicutes bac...
CCZ46392        8 PADYVTTQW--SGGATTQLaia-pkgAVYAdrD-FLWRLSSATVELDeSDFTPLPAYDRVISTLRGD--MVLAHNg---- 77  Firmicutes bac...
WP_011706749   31 ESDQLKMPWKNKQGTTAQIlis-pagTSLDrlD-FAYRLSSAPIKGA-GPFSKFPGYQRILLPISGA-GFVLNGH----- 101 Aeromonas hydr...
Q6MKV0         19 SSTYQRMPWKNGLGVTDQIdlalse---ikssqpYSWRLSSALVTAS-NPFSIFEGYHRLLSVVQGD-GLVLNQR----- 88  Bdellovibrio b...
ACR68352        9 LGDYQSMPWHNGQGTTREImre-dnaSGSR----FRWRLSMADITCD-APFSAYGGYQRILSLLEGP-GLRLTIDg---- 77  Edwardsiella i...
Q88CZ5          9 AHDYPRMPWKNGGGFTEEItrd--sgEGLD--G-FGWRLSIADIEES-GGFSTFAGYQRIITVLQGD-GMRLLVDg---- 77  Pseudomonas pu...
Q4KJN9          9 AADYPRMPWKNGGGSTEEIard--tgDGLD--G-FGWRLSIADIAES-GGFSSFAGYQRVITVLQGA-GMQLTIDg---- 77  Pseudomonas pr...
1YLL_D         80 aESAPLRARQAFAFSGDSEVHCTLLDGAIRDFNLIYAPRRHR-ARLQWLRVEGELDWHg--TASTLll----------fA 146 Pseudomonas ae...
WP_012071566   85 hTNKLSNALDIARFSGGDTTYATLKNGKIEDLNIMVRETDTQ-ANVQAFTAPCSLLFS---NNSTLfsndhflfcgfyvC 160 Marinomonas sp...
jgi:Sama_0070  79 eARVQHADSSPWAFDGGLSVHAELTTAVVEDFNLFVPKGRLKlASRQQLAEHQRWHQAaeaGASVYgv----------fL 148 Shewanella ama...
CDB02632       81 -DSHSLSPYEQCTFDGALKV---LSRGRAVDYEMTLRKGRS--GRVEFLGRVSDLSIKedpGYLgl------------yC 142 Firmicutes bac...
CCZ46392       78 gERLTLHPYEIHDFSGADDTHSW---GRCTDFNLMLRRGQCR-GCVTAHFPHGTETLAlhaGETAll-----------fC 142 Firmicutes bac...
WP_011706749  102 ----PYATFEAAHFSGDDDTHCELLKKEVTDLGLIYDPARLS-ANIRVLNLPFPLTLTl-eADKTYlc----------yL 165 Aeromonas hydr...
Q6MKV0         89 ----PLLPFQVCEFSGDDHTDCQLIGSAVRDLGLIFNPKTHQ-ARMQFHSLPAMSETVlslPEETQff----------yL 153 Bdellovibrio b...
ACR68352       78 sAQQPLRGNGIVRFSGDSRVSSQLCDGPVRDLNLIYDPRHYG-ARLQWLDIRPTMPPLr-cHASTIll----------fC 145 Edwardsiella i...
Q88CZ5         78 qASRPLLAFDAFAFSGESQVSCKLLGGAIRDFNLIYAPQRYR-ARLQWL--DGTSRVYs--SASTVll----------fA 142 Pseudomonas pu...
Q4KJN9         78 eDVRPLLPLDAFAFSGASQVDCTLLEGAIRDFNLIYCPQRYV-ARLQWL--DGQQRFFt--QAHTLll----------fS 142 Pseudomonas pr...
1YLL_D        147 QQDGVAISLQgq-pRGQLAAHDCLCAEGLQglqhwRLTAHEPAWV 190 Pseudomonas aeruginosa PAO1
WP_012071566  161 EDGVLEIENT----ALTISAHSMVVFSQNA-----NAKLTKGSGV 196 Marinomonas sp. MWYL1
jgi:Sama_0070 149 RSGQVSIg------DIQLSSDHPLIISSTPl----NLLAEAPSDL 183 Shewanella amazonensis SB2B
CDB02632      143 LKGSLRIYSKd--gEHLLYEGDQFSAFSDEt---kELRLEGEALV 182 Firmicutes bacterium CAG:145
CCZ46392      143 GEGSVTLHAGt--eTLTLAAHESALIGDAPa----QLTVEGSAKL 181 Firmicutes bacterium CAG:129
WP_011706749  166 LSGQLTAa------GHPMAVNETLLISGEQs---iHFDCQKKSAI 201 Aeromonas hydrophila
Q6MKV0        154 AKGRMRIa------DQTAAAQDCFKLTHET-----QVKIQNTese 187 Bdellovibrio bacteriovorus
ACR68352      146 RQGDLSLTPLgaaaSLQLTRYDSAILQTPCpq-thSVDIRGHGQL 189 Edwardsiella ictaluri 93-146
Q88CZ5        143 ASSLVEVTISgr-eTQRLGLFDCLRLEGNDellglVV----QGRC 182 Pseudomonas putida KT2440
Q4KJN9        143 AAEQAWVDTGsa-pVQALGRYDCLRLEGNRgllevAL----DGLC 182 Pseudomonas protegens Pf-5
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