1YLL


Conserved Protein Domain Family
HutD

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pfam05962: HutD 
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HutD
HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilization operon. HutD is operonic with the well characterized repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription. The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.
Statistics
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PSSM-Id: 428694
Aligned: 42 rows
Threshold Bit Score: 137.064
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YLL_D                    11 AVDYPRXPWKNGAGSTEEI-AR--------D-GGDGLD--G-FGWRLSIADVGES-GGFSGFAGYQRIISVLEGG-GXRL 75  Pse...
jgi:Sama_0070              8 AKDFVTNDW--AGGSTTQL-LIh-------P-KGSSLAarD-FEFRLSCARVEQS-GQFSDFSGYDRLLLVLEGA--MKL 72 
CDB02632                  14 ITR-----W--AGGRTRQL-AIy-------PqDAQGAEafD-FVFEITSSTTDIKeSEYTIYESYNRTLMIISGEsALTL 77 
CCZ46392                   8 PADYVTTQW--SGGATTQL-AIa-------P-KGAVYAdrD-FLWRLSSATVELDeSDFTPLPAYDRVISTLRGD--MVL 73 
Q87UW9                     9 AADYPRMPWKNGGGSTEEI-AR--------D-AGQDLD--G-FGWRLSIADIDTS-GGFSVFAGYQRIITVLQGA-GMTL 73  Pse...
BAN51043                   9 AADYPRMPWKNGAGSTLEI-TR--------D-AGDGLD--G-FGWRLSIADVGES-GGFSAFTGYQRVITVLEGA-GMRL 73 
tigr:AHA_2951             31 ESDQLKMPWKNKQGTTAQI-LIs-------P-AGTSLDrlD-FAYRLSSAPIKGA-GPFSKFPGYQRILLPISGA-GFVL 98 
Q6MKV0                    19 SSTYQRMPWKNGLGVTDQIdLAlseikssqP-----------YSWRLSSALVTAS-NPFSIFEGYHRLLSVVQGD-GLVL 85  Bde...
PRJNA391730:Sp245p_27340   1 ------MPWKNGGGTTTEIaLQ----------ELPGAA--GrFLWRVSIADVAEA-GPFSAFTGYERLIAVVEGA-GMRL 60 
CBS90735                   9 PADHRRVPWKNGGGVTTEL-AVe-------P----ATD--GrFLWRVSIADVVEP-GPFSAFPGYDRLIAVVEGD-GMRL 72 
1YLL_D                    76 RVDg--AESAPLRARQA-FAFSGDSEVHCTLLDGAIRDFNLIYAPRRHR-ARLQWLRVeGELDWHG--TASTLllfAQQD 149 Pse...
jgi:Sama_0070             73 SGNalseARVQHADSSP-WAFDGGLSVHAELTTAVVEDFNLFVPKGRLKlASRQQLAEhQRWHQAAeaGASVYgvfLRSG 151
CDB02632                  78 EDG----DSHSLSPYEQ-CTFDGALKV---LSRGRAVDYEMTLRKGRS--GRVEFLGRvSDLSIKEdpGYLgl--yCLKG 145
CCZ46392                  74 AHNg--GERLTLHPYEI-HDFSGADDTHSW---GRCTDFNLMLRRGQCR-GCVTAHFPhGTETLALhaGETAll-fCGEG 145
Q87UW9                    74 EVDg--VASRPLLPSDP-FAFSGDSAVSCTLLDGPIRDFNLIYAAHRYT-ARLHWIDVrHPQRLFS--SASTFvlfSMAE 147 Pse...
BAN51043                  74 EVDg--HLSRDLTALDA-FAFDGGSVVDCELLDGPIRDFNLIYSPQRYT-ARLQWLPIdGELKLFS--AATTLllfAADG 147
tigr:AHA_2951             99 NGH-------PYATFEA-AHFSGDDDTHCELLKKEVTDLGLIYDPARLS-ANIRVLNLpFPLTLTLe-ADKTYlcyLLSG 168
Q6MKV0                    86 NQR-------PLLPFQV-CEFSGDDHTDCQLIGSAVRDLGLIFNPKTHQ-ARMQFHSLpAMSETVLslPEETQffyLAKG 156 Bde...
PRJNA391730:Sp245p_27340  61 TVDg--VPATVTNRATP-FRFSGDAAVDCALLDGPIRDFNLIFDRERAD-ARLDILPAdTAADIPAggMAlv---hALAG 133
CBS90735                  73 SVDg--APPVERRRLDPaFAFPGEAAVWCEPTAGPIRDVNLMLARASAT-GTLSLLTGlAGQHA----DGDVVlvhALAG 145
1YLL_D                   150 gvaislQGQpRGQLAAHDCLCAEGLQglqhwRLTAHEPAWVCA 192 Pseudomonas aeruginosa PAO1
jgi:Sama_0070            152 qvs-----igDIQLSSDHPLIISSTPl----NLLAEAPSDLva 185
CDB02632                 146 slriysKDG-EHLLYEGDQFSAFSDEt---kELRLEGEALVIq 184
CCZ46392                 146 svtlhaGTE-TLTLAAHESALIGDAPa----QLTVEGSAKLML 183
Q87UW9                   148 qvaisvDGQpWEILGKHDCALVDNPGglleiELQSPRVSRCCL 190 Pseudomonas syringae pv. tomato
BAN51043                 148 evaaslDDVaAGSLGRHDCLHLENQGqlaelKL--AGTGTLCL 188
tigr:AHA_2951            169 qlt-----aaGHPMAVNETLLISGEQs---iHFDCQKKSAIAF 203
Q6MKV0                   157 rmr-----iaDQTAAAQDCFKLTHET-----QVKIQNTesetl 189 Bdellovibrio bacteriovorus
PRJNA391730:Sp245p_27340 134 ----------EVILRTGDSVARVSPGw----TARLDDTAATLE 162
CBS90735                 146 clsvtpDGGdTLPVPEGHSLLLRDGT------------ARVEV 176
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