Conserved Protein Domain Family
APC_basic

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pfam05956: APC_basic 
APC basic domain
This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Statistics
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PSSM-Id: 399151
Aligned: 12 rows
Threshold Bit Score: 289.47
Threshold Setting Gi: 1249022078
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015220786 2017 VVFRGRTVIYMPNpKKETNSSQKPPLKKTSPKt--------ETPV-KNPNLAQQRSRSlHRLGRANDSTELSLPKRSSTP 2087 spotted gar
XP_022536604 2175 VVSRGRTMTHVPG-VRSSSPSTSPIPKKPPAR---------GQVA-KPPSQGPNSVNS-PRSIKPPSKTDPSPARESPAT 2242 Mexican tetra
P25054       2223 SISRGRTMIHIPG-VRNSSSSTSPVSKKGPPL---------KTPAsKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQ 2291 human
XP_008122667 1928 VVFRGRTVIYMPKvSKESQ---VQSPRCTPKKtgpi--tktESPL-KNGNLNQQRSRSlHRPGKISEIADLSLPKRSATP 2001 green anole
EDL31570     1757 TMLRGRTVIYSAGpASRTQSKGISGPCTTPKKtgtsgttqpETVT-KAPSPEQQRSRSlHRPGKISELAALRHPPRSATP 1835 house mouse
XP_006050589 1816 AVLRGHTVIYMPTpATRAQPRGAPGSRIVARKmgapspvqpAAPT-KAPNPGQQRSRSlHRPGKISELATLSPPQRSATP 1894 water buffalo
XP_012904217 1784 AVLRGRTVIYVPSpAPRAQPKGHPGTHVAPRKmgppspaqpGAPA-KTPSPGQQRSRSlHRPGKSSELAALSPPQRSATP 1862 domestic ferret
XP_007240270 1960 VVFRGRTVIYTP--KKETTLSQRPPPKKVTPK---------DAP--KNPNLAQHRSRSlHRLGRPNDSTQLSLPKRSSTP 2026 Mexican tetra
XP_019201773 1949 VVFRGRTVIYTP--KKEMAPSQRPPPRKVPTKt--------DAP--KNPNLAQHRSKSlHRLGHPQD-MELSLPKRSSTP 2015 Nile tilapia
XP_011472584 1954 VVLRGRTVIYTP--KKETAPSQRPPPRKVSTKt--------DAP--KNPNLAQHRSKSlHRLGHPQD-TELSLPKRSYTP 2020 Japanese medaka
XP_005999939 1983 VVFRGRTVIYMP--------KESASPRSTPKKta-----knDAFP-QNSNQLQQRSRSlHRLEKSTELADLSLQKRSATP 2048 coelacanth
XP_014351222 1935 mVSRGRTMIHIPG-VRNSSPSTSPVSNKTPPK---------NTPS-KSPSSNQISSNS-PRGFKGSGKSDPNPVGRQTGA 2002 coelacanth
XP_015220786 2088 PARIPKSTSSGSSQNSTPSRQPQKKLTSPSQSSKQIPKKDVK------------------------------------PT 2131 spotted gar
XP_022536604 2243 PGGSSKASSRSGSRDSTPSRPPQQSLTRPMQSPGRNSVSPGRngl------------------------------tppNK 2292 Mexican tetra
P25054       2292 IGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRngi------------------------------sppNK 2341 human
XP_008122667 2002 PARMTKAPSSGSSRTSTPSQPNQKKLTSPSQPQASSRGSGKAdls------------------------------sssPG 2051 green anole
EDL31570     1836 PARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGS-------------------------------------- 1877 house mouse
XP_006050589 1895 PARLAKTPSSSSSQTSPASQPLPRRSPPAAQPAGPLPGPRAS-------------------------------------- 1936 water buffalo
XP_012904217 1863 PARLAKAPSSGSSPASPASQAPTRRLPTGTQAAGPLPGPGAA-------------------------------------- 1904 domestic ferret
XP_007240270 2027 PARIPKSSSSGSSQSSTPCRQPYKKITSPTQTVKQSPKVASSa-----------------------------------PS 2071 Mexican tetra
XP_019201773 2016 PPRIPKSSSSGSSQSSTPSKQSQKKitspaqtnksiqKKNATpas------------------------------sppAT 2065 Nile tilapia
XP_011472584 2021 PPRIPKSSSSGS----------------------------GSsqsstpskqsqkkitsptqtnkaiekksttspsgssvs 2072 Japanese medaka
XP_005999939 2049 PARISKGPSSGSSRNSTPSRQPQKKLTSPSQINKQLTGPGTRsng----------------------------------- 2093 coelacanth
XP_014351222 2003 QGGSSKGTSRSGSRDSTPSRPAQQPLSRPMQSPGRSSISPGRngi------------------------------nppNK 2052 coelacanth
XP_015220786 2132 NSPTDKKTSPAASPsPK--------SPAhKKTQKSPVRIPFMQTPSR-QPMASRTISPLvtnqp---spgiSRQNTQLKR 2199 spotted gar
XP_022536604 2293 LSQIPRTVSPSAAS-KP--------AGSgRMTYASPGRQLSQHTPSKqQSGLPRSTSGI------------PRSESASKV 2351 Mexican tetra
P25054       2342 LSQLPRTSSPSTAStKS--------SGSgKMSYTSPGRQMSQQNLTK-QTGLSKNASSI------------PRSESASKG 2400 human
XP_008122667 2052 ANPKPVQKSPA----SK--------Q---NKTQKSPVRIPFMQKPAK-KTILMRNTMPVleeqvgrgtgrdPRPKSNVKG 2115 green anole
EDL31570     1878 ----LVPKSPARALlAK--------Q---HKTQKSPVRIPFMQRPAR------RVPPPLarps----pepgSRGRAGAEG 1932 house mouse
XP_006050589 1937 ----PVPKTQARALlAK--------Q---HKTQKSPVRIPFMQRPAR------RGPPPLaraa----pepgPRGRVGAEG 1991 water buffalo
XP_012904217 1905 ----LVPQTPTRALlSK--------Q---HKTQKSPVRIPFMQRPAR------RGPPALaraa----pepgPRGRAAAEG 1959 domestic ferret
XP_007240270 2072 SPPEKKGCVSPPNQnPK--------SPPdSKTQKSPVRIPFMQNPTR----QSRAISPLvtnqp--tstnrPNSGTQITG 2137 Mexican tetra
XP_019201773 2066 SPPERKGRSPVVNQnEK--------SPP-PKTQKSPVRIPFMQNSVR----QPRPLSPLvtn------qttGRQTNQVNG 2126 Nile tilapia
XP_011472584 2073 spPERKGRSPVVNKnEK--------SPP-PKTQKSPVRIPFMHTSTK----QPRPLSPLvtn------htvNRQISQVNG 2133 Japanese medaka
XP_005999939 2094 -sipEKKCNPAVSTtTKsdnkspgpK---NKTQKSPVRIPFMQTPTKkVIPQRNNSSPLin--------qfNRQKQNLNG 2161 coelacanth
XP_014351222 2053 LSQLPRTSSPSPGStKS--------SGSgRMAYTSPGRHLGQQPPSK-QTNLPKSASGI------------PRSESASKG 2111 coelacanth
XP_015220786 2200 -------TLPANRLDLVRMSSTRSSSSE-SDRA---GFLRQLTFIKESPS-LLRQRSEIPSS-RS------VPTsk-cAS 2259 spotted gar
XP_022536604 2352 lnq-sgaSGPPKKAELSRMSSTKSSGSE-SDRSekpGLVRQSTFIKEAPSpTLKRKLEESASfES------LSP----SS 2419 Mexican tetra
P25054       2401 lnqmnngNGANKKVELSRMSSTKSSGSE-SDRSerpVLVRQSTFIKEAPSpTLRRKLEESASfES------LSPssrpAS 2473 human
XP_008122667 2116 t-------LQSSRLNLVRVSSARSVSGE-SDRS---GFLRQLTFIKESSTlLMRHRTKLSSS-SAprasspCSSlsqgAS 2183 green anole
EDL31570     1933 t-----pGARGSRLGLVRMASARSSGSEsSDRS---GFRRQLTFIKESPGlLRRRRSELSSA-DS------TAStsqaAS 1997 house mouse
XP_006050589 1992 g-----sAARGGRLGLVRMASARSSGSEsSDRS---GFRRQLTFIKESPGlMRRRRSELSAP-EA------TNPttqaAS 2056 water buffalo
XP_012904217 1960 s-----pGARGGRLGLVRVASARSSGSEsSDRS---GFRRQLTFIKESPGlLRRRRLELSTP-EA------ARPasqgGS 2024 domestic ferret
XP_007240270 2138 r-----rILPANRLDLVRMTAAHSRSGE-TDRN---GFLRQLTFIKESAN-VSRQ--DIPGS-RS------VPTsk-hGS 2197 Mexican tetra
XP_019201773 2127 k-----rVVPANRFDLVRMTSVHSSGSE-SDRN---GFLRQLTFIKESKT-MLRR--D-SSA-RN------AAGsq-nGS 2185 Nile tilapia
XP_011472584 2134 k-----rMAPVNKFDLVRMTSVHSNGSE-SDRS---GFLRQLTFIKESKT-ALRR--D-SCP-RN------MPGsq-nGS 2192 Japanese medaka
XP_005999939 2162 k------NLQPTRLDLVRMSSARSSGSE-SDKS---GFLRQLTFIKESSShILRQRSEISSS-ES------LSSlsrcAS 2224 coelacanth
XP_014351222 2112 lnh-sanSGSGKKVELSRMSSTKSSGSE-SDRSerpVLVRQSTFIKEAPSpTLRRKLEESASfES------LSPssrpAS 2183 coelacanth
XP_015220786 2260 PRKMR-------PGAPAAFLCSsrCQELKGVGQGPRE---------------------T------------------Qde 2293 spotted gar
XP_022536604 2420 PSQSQtpv--ssPSLPDMSLSL--PYQGSGWKKSPQS---------------------Q------------------N-- 2454 Mexican tetra
P25054       2474 PTRSQaqtpvlsPSLPDMSLSThsSVQAGGWRKLPPN---------------------L------------------Sp- 2513 human
XP_008122667 2184 PRRGR-------LGLPTVFLCSsrCDDLK--AEKPLG---------------------A------------------Sqr 2215 green anole
EDL31570     1998 PRRGR-------PALPAVFLCSsrCDELRVSPRQPLA---------------------A--------------------- 2028 house mouse
XP_006050589 2057 PCRGR-------PALPAVFLCSsrCDELRVGSRQAPA---------------------P--------------------- 2087 water buffalo
XP_012904217 2025 PRRSQ-------PALPAVFLCSsrCDELRAAPRQAPV---------------------P--------------------- 2055 domestic ferret
XP_007240270 2198 PRRAR-------PGAPAVFLCSsrCQELKPTAQGPRR---------------------L------------------Qgl 2231 Mexican tetra
XP_019201773 2186 PRRAV-------PGASAVFLCSsrCQELKAAVQPPRR---------------------VqvkdpdqkqqiqrpntglQkq 2237 Nile tilapia
XP_011472584 2193 PRRAV-------PGAPAVFLCSsrCQELKATVQAPKRvqvkdppqtwqdqkptqglqkQ------------------Tst 2247 Japanese medaka
XP_005999939 2225 PRKSK-------SDIPAVFLCSsrCQELK--VAKPVM---------------------P------------------Nhn 2256 coelacanth
XP_014351222 2184 PTRSQiqtpvlsPSLPDMLVSAhsPHQINSWRKSPHN---------------------H------------------Np- 2223 coelacanth
XP_015220786 2294 gqgqga-----qrqraalsRASSSDRGLSGVRPARRTSSESPCRAPQ-KNISga-----wqRERDTFKRHSSSPHINILK 2362 spotted gar
XP_022536604 2455 -------------------SSENGDGKSIRRQDISRSHSESPSRLPInRAGT---------WKREHSKHSSSLPRVGTWK 2506 Mexican tetra
P25054       2514 -------------------TIEYNDGRPAKRHDIARSHSESPSRLPInRSGT---------WKREHSKHSSSLPRVSTWR 2565 human
XP_008122667 2216 p---------------vipRGTP-----VGTKPPRRTSSESPSRLPV-KTNN---------LPPEPFKRYSSSPQINVTK 2265 green anole
EDL31570     2029 -------------------QRSPQAKPGLAPRAPRRTSSESPSRLPV-RASP---------GRPETVKRYASLPHISVSR 2079 house mouse
XP_006050589 2088 -------------------QRAHTARPRPSERQPRRTSSESPSRLPV-RTPA---------AXPETVKRYASLPHISVAR 2138 water buffalo
XP_012904217 2056 -------------------QRAPAARPSPSERPARRPSSESPSRLPV-RTPT---------APPEAVKRYASLPHISVAR 2106 domestic ferret
XP_007240270 2232 qgqrngqeqgilkqnmtlsRANSTDRDLTVRRPARRTSSESPCRIPQ-RNIPepk---preKKDDTFKRYSSSPSINVLS 2307 Mexican tetra
XP_019201773 2238 tt--------------tlsRATSSERDLSSRRPARRTSSESPCRVAQ-RNGPgrvsglrqqQDKDTFKRHASSPSINILS 2302 Nile tilapia
XP_011472584 2248 -----------------lsRATSSERDLT-KRAARRTSSESPCRMAE-RNGPartsggkkqQDKDTFKRHASSPSINILS 2308 Japanese medaka
XP_005999939 2257 v---------------tlsKTTTS----SDRKHPKRTSSESPSRPPV-KNNP---------MQREILKRHSSFPHINMRK 2307 coelacanth
XP_014351222 2224 -------------------PLEPGDGRVMRRHDITRSHSESPSRLPVnRSGT---------WKREHSKHSSSLPRVSTWR 2275 coelacanth
XP_015220786 2363 RATSRSSILS 2372 spotted gar
XP_022536604 2507 RTGSSSSILS 2516 Mexican tetra
P25054       2566 RTGSSSSILS 2575 human
XP_008122667 2266 RTASLASTVp 2275 green anole
EDL31570     2080 RSDSAVSVPT 2089 house mouse
XP_006050589 2139 RPDATSPEPA 2148 water buffalo
XP_012904217 2107 RPDGAAPGAG 2116 domestic ferret
XP_007240270 2308 RVTSRSSLRS 2317 Mexican tetra
XP_019201773 2303 RVTSRSSLRS 2312 Nile tilapia
XP_011472584 2309 RVTSRSSLRS 2318 Japanese medaka
XP_005999939 2308 RTNSPSVFSS 2317 coelacanth
XP_014351222 2276 RTGSSSSILS 2285 coelacanth
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