1TH1


Conserved Protein Domain Family
APC_r
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pfam05923: APC_r (This model is not part of the current CDD release)
APC repeat
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Links
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Statistics
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PSSM-Id: 517035
Aligned: 32 rows
Threshold Bit Score: 32.7547
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1TH1_C         10 SPPEHY-VQETPLMFSRCTSVSSL 32   human
XP_001955695  768 DAPRSYcTEDTPALLSKAPSNSDL 791 
XP_002000958 1178 ETTRSYcTEDTPALLSKVGSNTNL 1201
XP_001989971  811 DEQRNYcTEDTPALLSKAGSNSNL 834 
XP_001687753  668 DSVKCYyTEGTPQIISSATSMSDL 691 
1_pfamImport    1 DTTQTYcTEGTPYNFSNAASYTDL 24  
XP_009018419  985 DTLKVYaEEGTPFEISRVTSLSDI 1008
XP_008198134  432 DSVKTYcTEDTPAILSHAGSNSDL 455 
NP_477152     837 DSVKCYqTEDTPYVISNAASVTDL 860  fruit fly
Q9Z1K7       1370 DDSGTDsAEGTPVNFSSAASLSDE 1393 house mouse
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